共查询到20条相似文献,搜索用时 15 毫秒
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Maayan Amit Noa Sela Hadas Keren Ze'ev Melamed Inna Muler Noam Shomron Shai Izraeli Gil Ast 《BMC molecular biology》2007,8(1):109
Background
Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. 相似文献2.
Alexander Y Panchin Mikhail S Gelfand Vasily E Ramensky Irena I Artamonova 《Biology direct》2010,5(1):54
Background
Gene duplications are a source of new genes and protein functions. The innovative role of duplication events makes families of paralogous genes an interesting target for studies in evolutionary biology. Here we study global trends in the evolution of human genes that resulted from recent duplications. 相似文献3.
Mark TA Donoghue Channa Keshavaiah Sandesh H Swamidatta Charles Spillane 《BMC evolutionary biology》2011,11(1):47
Background
All sequenced genomes contain a proportion of lineage-specific genes, which exhibit no sequence similarity to any genes outside the lineage. Despite their prevalence, the origins and functions of most lineage-specific genes remain largely unknown. As more genomes are sequenced opportunities for understanding evolutionary origins and functions of lineage-specific genes are increasing. 相似文献4.
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription 下载免费PDF全文
Nakaya HI Amaral PP Louro R Lopes A Fachel AA Moreira YB El-Jundi TA da Silva AM Reis EM Verjovski-Almeida S 《Genome biology》2007,8(3):R43
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Background
Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws. However, for many outcrossing species, such pedigrees are not available and genes also display population properties. 相似文献6.
In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR 总被引:1,自引:0,他引:1
Monika Jung Azizbek Ramankulov Jan Roigas Manfred Johannsen Martin Ringsdorf Glen Kristiansen Klaus Jung 《BMC molecular biology》2007,8(1):47
Background
Housekeeping genes are commonly used as endogenous reference genes for the relative quantification of target genes in gene expression studies. No conclusive systematic study comparing the suitability of different candidate reference genes in clear cell renal cell carcinoma has been published to date. To remedy this situation, 10 housekeeping genes for normalizing purposes of RT-PCR measurements already recommended in various studies were examined with regard to their usefulness as reference genes. 相似文献7.
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Sylvie Grandemange Sophie Schaller Shigeru Yamano Stanislas Du Manoir George V Shpakovski Marie-Geneviève Mattei Claude Kedinger Marc Vigneron 《BMC molecular biology》2001,2(1):14
Background
The sequences encoding the yeast RNA polymerase II (RPB) subunits are single copy genes. 相似文献9.
David Honys Sung-Aeong Oh David Reňák Maarten Donders Blanka Šolcová James Andrew Johnson Rita Boudová David Twell 《BMC plant biology》2006,6(1):31-9
Background
The effective functional analysis of male gametophyte development requires new tools enabling the spatially and temporally controlled expression of both marker genes and modified genes of interest. In particular, promoters driving expression at earlier developmental stages including microspores are required. 相似文献10.
Barbara Hutter Matthias Bieg Volkhard Helms Martina Paulsen 《BMC evolutionary biology》2010,10(1):116
Background
In contrast to the majority of mammalian genes, imprinted genes are monoallelically expressed with the choice of the active allele depending on its parental origin. Due to their special inheritance patterns, maternally and paternally expressed genes might be under different evolutionary pressure. Here, we aimed at assessing the evolutionary history of imprinted genes. 相似文献11.
Background
Analysis of molecular evolutionary patterns of different genes within metabolic pathways allows us to determine whether these genes are subject to equivalent evolutionary forces and how natural selection shapes the evolution of proteins in an interacting system. Although previous studies found that upstream genes in the pathway evolved more slowly than downstream genes, the correlation between evolutionary rate and position of the genes in metabolic pathways as well as its implications in molecular evolution are still less understood. 相似文献12.
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Background
Prior to cluster analysis or genetic network analysis it is customary to filter, or remove genes considered to be irrelevant from the set of genes to be analyzed. Often genes whose variation across samples is less than an arbitrary threshold value are deleted. This can improve interpretability and reduce bias. 相似文献15.
Background
Identifying essential genes in bacteria supports to identify potential drug targets and an understanding of minimal requirements for a synthetic cell. However, experimentally assaying the essentiality of their coding genes is resource intensive and not feasible for all bacterial organisms, in particular if they are infective. 相似文献16.
Background
Expression array data are used to predict biological functions of uncharacterized genes by comparing their expression profiles to those of characterized genes. While biologically plausible, this is both statistically and computationally challenging. Typical approaches are computationally expensive and ignore correlations among expression profiles and functional categories. 相似文献17.
Selection of reference genes for gene expression studies in human neutrophils by real-time PCR 总被引:1,自引:0,他引:1
Background
Reference genes, which are often referred to housekeeping genes, are frequently used to normalize mRNA levels between different samples. However the expression level of these genes may vary among tissues or cells, and may change under certain circumstances. Thus the selection of reference gene(s) is critical for gene expression studies. For this purpose, 10 commonly used housekeeping genes were investigated in isolated human neutrophils. 相似文献18.
Shinichiro Maruyama Motomichi Matsuzaki Kazuharu Misawa Hisayoshi Nozaki 《BMC evolutionary biology》2009,9(1):197-15
Background
Eukaryotic genes with cyanobacterial ancestry in plastid-lacking protists have been regarded as important evolutionary markers implicating the presence of plastids in the early evolution of eukaryotes. Although recent genomic surveys demonstrated the presence of cyanobacterial and algal ancestry genes in the genomes of plastid-lacking protists, comparative analyses on the origin and distribution of those genes are still limited. 相似文献19.
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