银环蛇咬伤致急性呼吸衰竭的治疗及临床观察

目的观察抗银环蛇毒血清和机械通气对银环蛇咬伤致急性呼吸衰竭的疗效。方法应用抗蛇毒血清和机械通气救治23例银环蛇咬伤致急性呼吸衰竭患者。结果银环蛇咬伤患者及早应用抗银环蛇毒血清,毒蛇咬伤后发生急性呼吸衰竭时间为2.5～16h。当患者出现睁眼困难、吞咽困难、呼吸节律改变或呼吸困难时,即予气管插管行机械通气,可获得较好的疗效。结论机械通气辅助抗蛇毒血清是救治银环蛇咬伤致呼吸衰竭有效的方法。     

机械通气辅助抗蛇毒血清抢救银环蛇咬伤致呼吸衰竭的临床分析

目的观察抗蛇毒血清和机械通气对银环蛇咬伤致呼吸衰竭的疗效。方法应用机械通气和抗蛇毒血清救治16例银环蛇咬伤致呼吸衰竭患者。结果16例病人全部救活。患者出现眼睑下垂,呼吸节律改变或呼吸困难时,及早予经鼻气管插管行机械通气和应用抗蛇毒血清,能有效地抢救蛇伤致呼吸衰竭患者生命。结论机械通气辅助抗蛇毒血清是救治银环蛇咬伤致呼吸衰竭的有效方法。     

毒蛇咬伤致急性呼吸衰竭的机械通气救治6例

目的 探讨机械通气救治毒蛇咬伤致急性呼吸衰竭的治疗效果。方法 用机械通气救治6例毒蛇咬伤致急性呼吸衰竭患者。结果 气管内插管是最佳的气道开放方法;控制通气时,理想的参数为潮气量12ml/kg,通气频率20次／分,呼吸比1：2,吸氧浓度0. 4;辅助通气是,压力支持通气为0.3-1.5kPa,触发敏感度为－3mmH2D。气管插管者辅助通气4－6h后撤机及拔管可获得成功。结论 气管内插管及机械通气是救治毒蛇咬伤致急性呼吸衰竭的最有效的方法。     

急救护理路径在银环蛇咬伤重症患者急救护理中的应用

目的探讨急救护理路径在银环蛇咬伤患者急救护理中的应用效果。方法选取我院2017年1月～2019年11月收治的银环蛇咬伤患者60例,按随机表法分为对照组和研究组。对照组给予毒蛇咬伤常规护理干预,研究组给予急救护理路径,观察比较两组患者入院处置时间、机械通气时间与住院时间,并对预见性气管插管、紧急气管插管、肺部感染与意外拔管等指标进行比较。结果两组患者经不同急诊护理干预后,研究组患者在入院处置时间、机械通气时间与住院时间方面均显著优于对照组,差异有统计学意义(均P0.05);而且研究组患者在预见性气管插管、紧急气管插管、肺部感染与意外拔管等指标上均显著优于对照组(均P0.05)。结论急救护理路径应用于银环蛇咬伤患者急救护理中的效果显著,可缩短救治时间和住院时间,降低并发症发生率,促进患者康复,值得临床推广应用。     

机械通气联合抗蛇毒血清救治银环蛇咬伤致呼吸麻痹25例

目的观察机械通气联合抗蛇毒血清救治银环蛇咬伤中毒致呼吸麻痹的效果。方法对我院急诊科联合应用有创机械通气和抗银环蛇毒血清救治的25例银环蛇咬伤中毒致呼吸麻醉患者的经验进行总结。结果经机械通气联合抗银环蛇毒血清治疗后,25例患者全部治愈出院。结论及时应用机械通气呼吸支持,配合应用抗银环蛇毒血清中和蛇毒治疗是提高银环蛇咬伤致呼吸麻痹抢救成功的有效措施。     

中西医结合救治毒蛇咬伤致急性呼吸衰竭的临床观察

目的 探讨中西医结合救治毒蛇咬伤致急性呼吸衰竭的治疗效果.方法 应用中西医结合的方法(机械通气、抗蛇毒血清结合中医中药)救治46例毒蛇咬伤致急性呼吸衰竭患者.结果 46例全部痊愈出院.结论 中西医结合治疗措施是救治毒蛇咬伤致急性呼吸衰竭的最有效方法.     

152例银环蛇咬伤致呼吸麻痹的救治体会

目的探索抗银环蛇毒血清、机械通气治疗银环蛇咬伤致呼吸麻痹的方法。方法收集我院救治的银环蛇咬伤致呼吸麻痹152例临床资料,阐明抗银环蛇毒血清、机械通气的临床疗效。结果治愈147例,治愈率为96.7％。结论银环蛇咬伤局部症状不明显,全身中毒症状重．死亡率高。银环蛇咬伤主要发生在农村,基层医院要尽快推广使用抗银环蛇毒血清;一但出现呼吸麻痹要尽早使用机械通气,对抢救成功致关重要。     

毒蛇咬伤致急性呼吸衰竭38例救治分析

目的探讨毒蛇咬伤致急性呼吸衰竭的发病机制和治疗措施。方法选择毒蛇咬伤患者38例,应用抗蛇毒血清、机械通气等综合治疗。结果经综合救治措施治疗,38例全部痊愈出院。结论综合救治措施是抢救毒蛇咬伤致急性呼吸衰竭最有效的方法。     

缺抗蛇毒血清治疗重症银环蛇咬伤的护理体会

目的探讨缺抗蛇毒血清救治银环蛇咬伤所致急性呼吸衰竭的护理措施。方法对2011年3月~2014年3月我院收治银环蛇咬伤未用抗银环蛇血清患者的临床资料进行回顾性分析,总结护理措施及特点,并评价患者的预后。结果 11例患者全部抢救成功,但住院时间较使用抗银环蛇血清的患者延长,差异有显著统计学意义(P0.05);其中4例病人发生呼吸机相关性肺炎;2例患者因镇静不良,出现严重的焦虑与恐慌等精神症状。结论在缺抗银环蛇毒血清救治银环蛇咬伤致急性呼吸衰竭患者的抢救中,呼吸机辅助呼吸是抢救的主要措施,而正确执行护理措施、减少呼吸机相关性肺炎可提高抢救成功率。     

1例银环蛇咬伤致严重呼吸衰竭的救治体会

2005年10月,我科成功救治1例银环蛇咬伤致严重呼吸衰竭患者,现报告如下。 1临床资料 1．1一般资料患者,男,41岁,右手食指被银环蛇咬伤4h于2005年10月5日23时20分由急诊收入院。患者家属代诉于当天19时左右,患者在抓蛇时不慎被银环蛇咬伤右手食指,当即感局部麻木,稍肿胀,并渐渐出现胸闷,呼吸不畅等不适。在当地医院静滴林格氏液1000ml,注射解毒药（不详）,并立即送往我院,途中患者胸闷,呼吸困难加重,即行气管插管（入院前1h）,并用气囊加压给氧,急诊以“毒蛇咬伤”收入住院。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.