共查询到20条相似文献,搜索用时 31 毫秒
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D. H. H. Kühlmann 《International Review of Hydrobiology》1985,70(5):768-769
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D. Khlmann 《International Review of Hydrobiology》1987,72(3):378-378
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《广西植物》1985,(4)
学名页Abies yuanbao、hanensist·4·1一一(231)A,ziy妞anensis··,·······一(231)Aeaeia aurieulaeformis Cunn·】,一(134)A .confu、a··-,····一,,··4一(201)Acanthaceae‘,,·t··……(35)Acer!····,4···,一···4·1·4··,·(34)A .dayidii Fr一一·一···一·……(135)A .tonk山ensi、·-4···········一·……(196)Aceraeeae··4···t···4一(34,217)Aehyranthes bidentata‘一4一一t4一(233)Acer rubronerviu扭Y.K.L卜····一(7)AcQrus二,,·,,t!,,···,·,4····4·… 相似文献
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Wirsching J Voss J Balzarini J De Clercq E 《Bioorganic & medicinal chemistry letters》2000,10(12):1339-1341
1-O-Acetyl-2,3,5-tri-O-benzyl-4-thio-L-arabinofuranoside (6) was transformed in two steps into the 1-(4-thio-L-arabinofuranosyl)-5-halopyrimidine nucleosides 10, 11 and 12, obtained as anomeric mixtures which were separable in the case of 10 and 11. No in vitro antiviral activity against HIV-1 and HIV-2. TK+ and TK- VZV and CMV has been found for 10, 11 and 12. 相似文献
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H. Caspers 《International Review of Hydrobiology》1984,69(3):451-452
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《The International journal of biochemistry》1987,19(3):293
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Gary M. Feinman 《American anthropologist》2003,105(2):380-380
The Cambridge History of the Native Peoples of the Americas: Vol. 2: Mesoamerica, Part 1. Richard E. W. Adams and Murdo J. MacLeod. eds. Cambridge: Cambridge University Press, 2000. 571 pp.
The Cambridge History of the Native Peoples of the Americas: Vol. 2: Mesoamerica, Part 2. Richard E. W. Adams and Murdo J. MacLeod. eds. Cambridge: Cambridge University Press, 2000. 455 pp. 相似文献
The Cambridge History of the Native Peoples of the Americas: Vol. 2: Mesoamerica, Part 2. Richard E. W. Adams and Murdo J. MacLeod. eds. Cambridge: Cambridge University Press, 2000. 455 pp. 相似文献
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《中国实验动物学报》2002,(4)
No .1ExpressionandSignificanceofVEGFReceptorsintheNudeMouseModelswithVariousHumanTumorsLIJunmin ,LUHongfen ,TIANPeikun ,etal(1)……………………………TheEfficientDerivationofEmbryonicStemCellColoniesinKun mingMouseZHOUXin ,WANGTaiyi,SHIWeihong ,etal(5 )……………………………………………………… 相似文献
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Mireille N Vankemmelbeke Gavin C Jones Cyprianne Fowles Mirna Z Ilic Christopher J Handley Anthony J Day C Graham Knight John S Mort David J Buttle 《European journal of biochemistry》2003,270(11):2394-2403
Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for cartilage aggrecan catabolism observed during the development of arthritis. We have previously reported that certain catechins, polyphenolic compounds found in highest concentration in green tea (Camellia sinensis), are capable of inhibiting cartilage aggrecan breakdown in an in vitro model of cartilage degradation. We have now cloned and expressed recombinant human ADAMTS-1, -4 and -5 and report here that the catechin gallate esters found in green tea potently inhibit the aggrecan-degrading activity of these enzymes, with submicromolar IC50 values. Moreover, the concentration needed for total inhibition of these members of the ADAMTS group is approximately two orders of magnitude lower than that which is needed to partially inhibit collagenase or ADAM-10 activity. Catechin gallate esters therefore provide selective inhibition of certain members of the ADAMTS group of enzymes and could constitute an important nutritional aid in the prevention of arthritis as well as being part of an effective therapy in the treatment of joint disease and other pathologies involving the action of these enzymes. 相似文献
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Sergeeva MV Zhou Y Bartkowski DM Nolan TG Norris DA Okamoto E Kirkovsky L Kamran R Lebrun LA Tsan M Patel R Shah AM Lardy M Gobbi A Li LS Zhao J Bertolini T Stankovic N Sun Z Murphy DE Webber SE Dragovich PS 《Bioorganic & medicinal chemistry letters》2008,18(11):3421-3426
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as potent inhibitors of genotype 1 HCV NS5B polymerase focusing on the optimization of their drug metabolism and pharmacokinetics (DMPK) profiles. This investigation led to the discovery of potent inhibitors with improved DMPK properties. 相似文献