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1.
The Oxford Whole Body Counter was used to measure absorption from various therapeutic preparations of iron in five groups of subjects. Succinic acid enhanced absorption of iron when added to a solution of ferrous fumarate, but not when given with tablets of ferrous fumarate or ferrous sulphate. Ferrous fumarate plus ascorbic acid was absorbed better than ferrous fumarate alone but no better than ferrous sulphate. The addition of ascorbic acid and succinic acid to tablets of ferrous sulphate did not enhance absorption significantly.  相似文献   

2.
Radiolabelled tablets of slow-release iron and ferrous sulphate containing 50 mg of elemental iron were given to 28 patients, and iron absorption was studied using a whole body counter.There was no significant difference between the absorption of ferrous sulphate and that of slow-release iron in normal subjects, anaemic patients, anaemic and non-anaemic post-gastrectomy patients, or those with coeliac disease. Ascorbic acid potentiated iron absorption, especially in anaemic post-gastrectomy patients.The indications and hazards of slow release iron preparations are discussed.  相似文献   

3.
Summary Application of iron as ferrous sulphate or chloride to a loam not deficient in manganese had no effect on the yield but increased the uptake of manganese even in barley which grew vigorously.In an experiment with sugar beet on two soils contrasted with regard to their available manganese supply, applications of manganese, iron and nitrogen were tested in all combinations. On the Købelev soil, not deficient in manganese, no increases in yields were obtained on addition of ferrous sulphate while increases in manganese uptake were found for all combinations of treatments except where iron was added in the presence of manganese.On the manganese deficient Faarevejle soil, significantly higher increases in yields of roots were obtained from ferrous sulphate in the presence of nitrogen than in the presence of manganese. The effect of iron in the presence of nitrogen on the yield of tops was also significant. These treatments also gave the highest increases in manganese uptake.The amounts of manganese extractable from the soils by magnesium nitrate over a range of pH 2–8 could be increased considerably by addition of ferrous sulphate.The results support the suggestion that application of ferrous sulphate to some soils has the same effect as an addition of manganese.  相似文献   

4.
Food fortification has been shown to be an effective strategy to overcome iron malnutrition. When a new iron compound is developed for this purpose, it must be evaluated from a nutritional and technological point of view before adding it into foods. In this way, we have evaluated ferrous gluconate stabilized by glycine as a new iron source to be used in wheat flour fortification. We performed biological studies in rats as well as sensory perceptions by human subjects in wheat flour fortified with this iron source. The productions of pentane as a rancidity indicator as well as the change of the sensorial properties of the biscuits made with stabilized ferrous gluconate-fortified wheat flour were negligible. Iron absorption in water from this iron source was similar to the reference standard ferrous sulfate. Nevertheless, because of the phytic acid content, iron absorption from fortified wheat flour decrease 40% for both iron sources. The addition of zinc from different sources did not modify iron absorption from ferrous sulfate and stabilized ferrous gluconate in water and wheat flour. The iron absorption mechanism as well as the biodistribution studies demonstrate that the biological behavior of this iron source does not differ significantly from the reference standard. These results demonstrate that the iron source under study has adequate properties to be used in wheat flour fortification. Nevertheless, more research is needed before considering this iron source for its massive use in food fortification.  相似文献   

5.
The apparent digestibility coefficient (ADC) of amino acids and the balance of minerals (calcium, phosphorus, magnesium and iron) has been determined in rats fed four diets differing in the protein type (casein or soy protein) and iron source (ferrous sulphate or lactate) in order to study the possible interactions of these nutrients. The availability of amino acids, especially essential amino acids, was greater in the diet made with animal protein (casein). The iron source also affected the absorption of most amino acids in all the diets assayed with ferrous sulphate being greater. The balance of iron, magnesium and phosphorus was higher in the diets containing animal protein. The retention of calcium and magnesium was significantly greater when ferrous sulphate was used as iron source. These results demonstrate the important interaction between amino acids and minerals and between the minerals themselves, which must be carefully studied when selecting different types of protein or mineral sources in human or animal nutrition.  相似文献   

6.
The repletion of iron stores after treatment was studied in 38 patients with uncomplicated iron-deficiency anaemia. The serum ferritin concentration rose significantly when oral treatment was continued for two months after the attainment of a normal haemoglobin concentration. Patients treated with a total-dose infusion of iron dextran had thehighest final serum levels, which were significantly greater than in patients given Ferro-Gradumet. Oral ferrous sulphate was almost as effective as parenteral iron in producing iron stores.  相似文献   

7.
Else Boken 《Plant and Soil》1956,7(3):237-252
Summary Pot experiments with oats on manganese deficient sandy and moor soils, which are not deficient in iron, showed a steady increase in yield and manganese uptake by the plants with increasing additions of ferrous sulphate at four levels of manganese. Residual effects from ferrous sulphate application were not found either in the case of yields or manganese uptake by oats on a sandy soil.The effect observed following application of ferrous sulphate was due to a manganese effect. This is corroborated by the coincidence of the yield curves, showing the relationship between absorbed manganese and yield of dry matter, following the application of manganese sulphate and ferrous sulphate.Soils treated withM magnesium nitrate in the presence of equivalent quantities of either ferrous sulphate or hydroquinone yielded the same amounts of manganese. This result suggests that the manganese effect of ferrous sulphate is due to reduction of higher manganese oxides by ferrous sulphate.  相似文献   

8.
Helicobacter pylori infection could impair iron absorption from fortified products. The objective of the study was to determine the effect of H. pylori infection on iron absorption from asymptomatic adults consuming wheat flour fortified with iron and zinc. The (13)C urea breath test was used to assess H. pylori infection. Twenty-four H. pylori-positive and 26 H. pylori-negative volunteers completed the study. On day?1, the subjects were randomized to receive for breakfast bread fortified with either ferrous sulfate and zinc sulfate or ferrous fumarate and zinc oxide. Bread fortified with ferrous sulfate was labeled with (59)Fe as sulfate, and bread fortified with ferrous fumarate was labeled with (55)Fe as fumarate. On day?3, they received the other type of bread, with the respective tracers. On days?18-23, a proton pump inhibitor was administered to all subjects. On day?24, all subjects received bread fortified with ferrous fumarate and zinc oxide labeled with (55)Fe as fumarate. H. pylori prevalence was 77.6%. The geometric mean (±1?SD) of iron absorption was significantly higher for ferrous sulfate than fumarate (6.9?±?2.9% vs. 0.5?±?3.5%, p?相似文献   

9.
Microalgae are extensively used in the remediation of heavy metals like iron. However, factors like toxicity, bioavailability and iron speciation play a major role in its removal by microalgae. Thus, in this study, toxicity of three different iron salts (FeSO4, FeCl3 and Fe(NO3)3) was evaluated towards three soil microalgal isolates, Chlorella sp. MM3, Chlamydomonas sp. MM7 and Chlorococcum sp. MM11. Interestingly, all the three iron salts gave different EC50 concentrations; however, ferric nitrate was found to be significantly more toxic followed by ferrous sulphate and ferric chloride. The EC50 analysis revealed that Chlorella sp. was significantly resistant to iron compared to other microalgae. However, almost 900 μg g?1 iron was accumulated by Chlamydomonas sp. grown with 12 mg L?1 ferric nitrate as an iron source when compared to other algae and iron salts. The time-course bioaccumulation confirmed that all the three microalgae adsorb the ferric salts such as ferric nitrate and ferric chloride more rapidly than ferrous salt, whereas intracellular accumulation was found to be rapid for ferrous salts. However, the amount of iron accumulated or adsorbed by algae, irrespective of species, from ferrous sulphate medium is comparatively lower than ferric chloride and ferric nitrate medium. The Fourier transform infrared spectroscopy (FTIR) analysis shows that the oxygen atom and P?=?O group of polysaccharides present in the cell wall of algae played a major role in the bioaccumulation of iron ions by algae.  相似文献   

10.
Iron has proved to be an integral component of the culture medium supporting the caulogenic response of the epicotyl segments of S. cuminii. In the absence of both the iron and EDTA even the shoot buds failed to develop, while in the presence of either of these, though the shoot buds developed, their elongation was adversely affected. Among the three iron sources tested, ferrous sulphate proved to be the best, as the ferric chloride was not as effective as the former when used either alone or along with EDTA. Ferric citrate, on the other hand, when provided alone, elicited better response than that induced by ferrous sulphate alone. However, in combination with EDTA, the response declined significantly. The estimation of endogenous levels of iron in the explants further supported these results. The quantum of iron absorption was at a maximum during the first week of the culture and the explants, once deprived of iron during the first week, failed to catch up to the level of iron accumulated in the explants maintained continuously on complete medium, even after transfer to the complete medium. Likewise, the level of copper ions did not come up to comparable levels even if the explants were transferred to the complete medium after initial deprivation.  相似文献   

11.
The severe deficiency of iron or ferric chlorosis is a serious problem of most citrus trees established in calcareous soils, as a result of the low availability of iron in these soils and the poor uptake and limited transport of this nutrient in trees. The objective of this study was to evaluate the response of chlorotic Italian lemon trees (Citrus lemon) to the application of iron compounds to roots and stems. On comparing the effects of aqueous solutions of ferric citrate, ferrous sulphate and FeEDDHA chelate, applied to 20% of the roots grown in soil and sand, of trees that were planted in pots containing calcareous soil, it was observed that the chelate fully corrected ferric chlorosis, while citrate and sulphate did not solve the problem. EDDHA induced the root uptake of iron as well as the movement of the nutrient up to the leaves. With the use of injections of ferric solutions into the secondary stem of adult trees, ferric citrate corrected chlorosis but ferrous sulphate did not. The citrate ion expanded the mobility of iron within the plant, from the injection points up to the leaves, whereas the sulphate ion did not sufficiently improve the movement of iron towards the leaf mesophyll.  相似文献   

12.
2 novel methods of coprophagy prevention were used in iron-deficient rats to measure their effect on haemoglobin regeneration during the feeding of ferrous sulphate or several soya proteins. Neck collars produced considerable weight loss and depression in food intake compared to aluminium anal cups which were tolerated well. Both methods of coprophagy prevention reduced iron availability from a range of soya proteins and ferrous sulphate and it is suggested that the practice of coprophagy in iron-deficient and possibly iron-replete rats may overestimate iron (and possibly other mineral) absorption (retention) studies.  相似文献   

13.
Objective Evaluate the safety and efficacy of bovine lactoferrin (bLf) versus the ferrous sulphate standard intervention in curing iron deficiency (ID) and ID anaemia (IDA) in pregnant women affected by hereditary thrombophilia (HT). Design Interventional study. Setting Secondary-level hospital for complicated pregnancies in Rome, Italy. Population 295 HT pregnant women (≥18 years) suffering from ID/IDA. Methods Women were enrolled in Arm A or B in accordance with their personal choice. In Arm A, 156 women received oral administration of 100 mg of bLf twice a day; in Arm B, 139 women received 520 mg of ferrous sulphate once a day. Therapies lasted until delivery. Main outcome measures Red blood cells, haemoglobin, total serum iron, serum ferritin (haematological parameters) were assayed before and every 30 days during therapy until delivery. Serum IL-6, key factor in inflammatory and iron homeostasis disorders, was detected at enrolment and after therapy at delivery. Possible maternal, foetal, and neonatal adverse effects were assessed. Results Haematological parameters were significantly higher in Arm A than in Arm B pregnant women (P ≤ 0.0001). Serum IL-6 significantly decreased in bLf-treated women and increased in ferrous sulphate-treated women. BLf did not exert any adverse effect. Adverse effects in 16.5 % of ferrous sulphate-treated women were recorded. Arm A women experienced no miscarriage compared to five miscarriages in Arm B women. Conclusions Differently from ferrous sulphate, bLf is safe and effective in curing ID/IDA associated with a consistent decrease of serum IL-6. The absence of miscarriage among bLf-treated women provided an unexpected benefit. Trial registration: ClinicalTrials.gov Identifier NCT01221844.  相似文献   

14.
The nutritional requirements for the oxidation of ferrous iron in acid mine water by fixed films of micro-organisms were investigated. Supplementing the mine leach liquor with additional ammonium, phosphate and potassium did not improve the efficiency of ferrous iron oxidation. The minimum non-limiting requirement of the ferrous iron oxidizing organisms for these nutrients was (mg/l): ammonium, 10; phosphate, 45, and potassium, 2·5. A strain of Thiobacillus was isolated which was able to grow on a medium to which only dihydrogen potassium phosphate, ferrous sulphate and agar had been added.  相似文献   

15.
Dave SR 《Bioresource technology》2008,99(16):7803-7806
Presence of Leptospirillum ferrooxidans plays significant role in ferric sulphate generation during bioleaching process. Thus, an attempt was made to select L. ferrooxidans from the polymetallic concentrate leachate and further developed it for enhanced ferric iron regeneration from the leachate in shake flask, stirred tank and column reactor. When ferric to ferrous iron ratio in the shake flask reached to 20:1, L. ferrooxidans out competed Acidithiobacillus ferrooxidans and accounted for more than 99% of the total population. The isolate was confirmed by 16S rRNA genes sequence analysis and named as L. ferrooxidans SRPCBL. When the culture was exposure to UV dose and the oxidation-reduction potential of the inoculation medium was adjusted to 40 0mV by ferrous:ferric iron ratio, the IOR reached to as high as 1.2 g/L/h in shake flask, even with initial ferrous iron concentration of 200 g/L. The chalcopyrite concentrate leachate containing 12.8, 15.7, and 42.0 g/L ferrous iron, ferric iron and copper, respectively was studied for ferric iron regeneration with the developed polymetallic resistant L. ferrooxidans SRPCBL in stirred tank and a developed biofilm airlift column, the highest IOR achieved were 2.20 g/L/h and 3.1 g/L/h, respectively, with ferrous oxidation efficiency of 98%. The ferric regeneration ability of the developed isolate from the leachate proves useful for a two-stage metal extraction process.  相似文献   

16.
The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: a) Low iron feed and biscuits with heme iron supplemented filling; b) Normal feed (with ferrous sulphate). Weight and blood parameters were measured every fifteen days. Averages were compared after duplicate analyses. The filling had a creamy appearance, chocolate taste and smell, appropriate spreadability, heme iron content of 2.6 mg per gram and a shelf-life of a month. The heme iron supplemented pigs registered a greater (P<0.05) weight gain (27.8% more than the control group). Mortality in the heme iron group was 10%, compared to 50% in the control group. The amount of iron measured in the different compartment was greater in the heme group (3315 mg) than in the control group (2792 mg). However, the amount of iron consumed in the latter was greater. We show that an acceptable product with high heme iron content can be formulated, suitable for use as biscuit filling. The heme iron supplement produced better weight increase and lesser mortality in fattening pigs. The bioavailability of heme iron was 23% greater (P<0.05) compared to ferrous sulphate.  相似文献   

17.
1. Strontium absorption was studied in vivo with loops of ileum in rachitic chicks and found to be increased by vitamin D(3), bile salts and sodium lauryl sulphate. 2. Bile salts and sodium lauryl sulphate rendered strontium soluble in butanol-benzene (1:1, v/v). 3. Bile was not concerned in the absorption of iron in rats from its water-soluble form, ferrous sulphate. 4. Ligation of the bile ducts in rats caused a decrease in the absorption of iron presented as its sparingly soluble phosphate. 5. The effect of bile on cation absorption is discussed.  相似文献   

18.
Naik  G. R.  Joshi  G. V. 《Plant and Soil》1979,53(4):505-511
Summary Sugarcane var. Co 740 is grown in various parts of Maharashtra (India) and is susceptible to chlorosis due to physiological non-utilization of iron. The physiological disorder is seen over a large area and it results in poor yield. Low sucrose yield can be recovered by foliar sprays of ferrous sulphate. The nonchlorotic and chlorotic leaves were used for the photosynthetic studies. The leaves after ferrous sulphate treatment show an increase in total chlorophyll contents and at the same time show an improved chlorophylla to chlorophyllb ratio which is affected in the chlorotic ones. The recovered green leaves have higher uptake of nitrogen, phosphorus, potassium and iron.14CO2 fixation studies for short- and long-term experiments reveal that recovered green leaves can synthesize malate more efficiently and also utilize it for sucrose synthesis more rapidly than in the chlorotic ones. On the contrary more amino acids, reducing sugars and sugar phosphates are synthesized in the chlorotic leaves. There is also an accumulation of citrate, glutamate, and tartrate in the chlorotic leaves. Our results indicate that sucrose synthesis is disturbed in the chlorotic leaves and can be corected byfolia: sprays of ferrous sulphate.  相似文献   

19.
The relative efficacy of infusion of black tea leaf, Camellia sinensis (Linn.) O. Kuntze, (Theaceae), and iron as freshly prepared aqueous solution of ferrous sulphate in reducing the cytotoxic effects of arsenic, was tested in bone marrow cells of laboratory bred Swiss albino mice. Ferrous sulphate and tea given alone did not induce chromosomal breakage to any appreciable extent. Tea decreased chromosome damage induced by arsenic to a significant extent, while the addition of ferrous sulphate did not alter the protective action of tea against arsenic. Such protection against arsenic cytotoxicity by prolonged dietary administration of black tea infusion--a common routine beverage--is of importance in view of widespread exposure of human populations to arsenic damage through drinking water from tubewells in Eastern India and Bangladesh.  相似文献   

20.
Fe(II)- and Fe(III)-induced lipid peroxidation of rabbit small intestinal microvillus membrane vesicles was studied. Ferrous ammonium sulphate, ferrous ascorbate at a molar ratio of 10:1, and ferric citrate, at molar ratios of 1:1 and 1:20, did not stimulate lipid peroxidation. Ferrous ascorbate, 1:1, induced low stimulation, while ferrous ascorbate, 1:20 gave higher stimulation of lipid peroxidation. These results show that in our experimental system, ascorbate is a promotor rather than an inhibitor of lipid peroxidation. Ferric nitrilotriacetate (at molar ratios of 1:2 and 1:10), at an iron concentration of 200 microM, was by far the most effective in inducing lipid peroxidation. Superoxide dismutase, mannitol and glutathione had no effect, while catalase, thiourea and vitamin E markedly decreased ferrous ascorbate 1:20-induced lipid peroxidation. Ferric nitrilotriacetate-induced lipid peroxidation was slightly reduced by catalase and mannitol, significantly reduced by superoxide dismutase, and completely inhibited by thiourea. Glutathione caused a 100% increase in the ferric nitrilotriacetate-induced lipid peroxidation. These results suggest that Fe(II) in the presence of trace amounts of Fe(III), or an oxidizing agent and Fe(III) in the presence of Fe(II) or a reducing agent, are potent stimulators of lipid peroxidation of microvillus membrane vesicles. Addition of deferoxamine completely inhibited both ferrous ascorbate, 1:20 and ferric nitrilotriacetate-induced lipid peroxidation, demonstrating the requirement for iron for its stimulation. Iron-induced peroxidation of microvillus membrane may have physiological significance because it could already be demonstrated at 2 microM iron concentration.  相似文献   

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