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1.
《Phytomedicine》2014,21(8-9):1021-1025
Baccharis trimera (Less.) D.C. (Asteraceae) is a medicinal species native to South America and used in Brazilian folk medicine to treat gastrointestinal and liver diseases, kidney disorders and diabetes. The aqueous extract (AE) of the aerial parts of this species presented two mainly constituents: the ent-clerodane diterpene (Fig. 1) and the neo-clerodane diterpene (Fig. 2). The objective of this work was to study their activities on the blockade of Ca2+-induced contractions in KCL-depolarized rat portal vein preparations, and on the influx and mobilization of cytosolic calcium in rat cardiomyocytes by fluorescence measurements. The results showed that both the neo- and the ent-clerodane diterpenes reduced the maximal contractions induced by CaCl2, in KCl depolarized rat portal vein preparations, without modifying the EC50. The data on the concentration of cytosolic calcium ([Ca2+]c) showed that, while the neo-clerodane diterpene stimulates the mobilization of [Ca2+]c in rat cardiomyocytes, this effect was not observed with the ent-clerodane diterpene. On the other hand, the influx of calcium was not altered by the neo-clerodane diterpene, but was reduced in the presence of the ent-clerodane diterpene, indicating that this compound induces a blockade of the voltage-dependent calcium channels. 相似文献
2.
Ping Guo Yushan Li Da-qing Jin Jing Xu Yisha He Lei Zhang Yuanqiang Guo 《Phytochemistry letters》2012,5(3):563-566
Two new neo-clerodane diterpenes, (12S)-6α-acetoxy-4α,18-epoxy-12-hydroxy-19-tigloyloxy-neo-clerod-13-en-15,16-olide (1) and 6α,18-diacetoxy-4α-hydroxy-19-tigloyloxy-neo-clerod-13-en-15,16-olide (2), along with three known analogs (3–5) have been isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, HMQC, HMBC, COSY, and NOESY). The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and compounds 1 and 5 showed inhibitory effects. 相似文献
3.
Leonidah K. Omosa Jacob O. Midiwo Solomon Derese Abiy Yenesew Martin G. Peter Matthias Heydenreich 《Phytochemistry letters》2010,3(4):217-220
Phytochemical investigation of the leaf surface exudate of Dodonaea angustifolia L.f. yielded two new neo-clerodane diterpenes, neo-clerodan-3,13-dien-16,15:18,19-diolide (mkapwanin) and 15-methoxy-neo-clerodan-3,13-dien-16,15:18,19-diolide (15-methoxymkapwanin). In addition, ten known compounds were identified. The structures were determined on the basis of spectroscopic evidence. This additional chemical information could contribute towards solving the taxonomical controversy that exists between Dodonaea angustifolia and Dodonaea viscosa Jacq., which are morphologically similar. 相似文献
4.
Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-induced nitric oxide inhibition assay employing murine macrophage cells. Among the assayed compounds, 13 (calycopterin) showed a concentration-dependent inhibition of LPS-induced nitric oxide release with a IC50 of 62.5 μM. 相似文献
5.
Maurizio Bruno Giuseppe Savona Conrad Pascual Benjamín Rodríguez 《Phytochemistry》1981,20(9):2259-2261
From the aerial part of Teucrium fragile a new neo-clerodane diterpenoid, teugin, has been isolated. Its structure, 15,16-epoxy- 2β,6β-dihydroxy-neo-cleroda-3,13(16),14-triene-18,19:20,12S-diolide, was established mainly by spectroscopic means. 相似文献
6.
From the whole plant of Ajuga chamaepitys two new neo-clerodane diterpenoids, ajugapitin and its dihydro derivative, have been isolated. Their 相似文献
7.
《Phytochemistry》1999,52(6):1055-1058
The antifeedant activity of three neo-clerodane diterpenoids, fruticolone, isofruticolone and fruticolide from Teucrium fruticans was assessed using larvae of Spodoptera littoralis. Isofruticolone was one of the most potent of the Teucrium derived neo-clerodanes. Chemical modification of functional groups on fruticolone showed that its activity could be enhanced. 相似文献
8.
《Phytochemistry》1987,26(12):3281-3283
A new neo-clerodane dilactone, desoxyarticulin, and dihydrotucumanoic acid, together with other known compounds, were isolated from Baccharis pedicellata and Baccharis marginalis. The structures of the new compounds were elucidated by spectroscopic methods. 相似文献
9.
《Phytochemistry》1987,26(2):479-482
From the aerial part of Salvia lasiantha a neo-clerodane diterpenoid, lasianthin, was isolated. The structure of this compound was established by spectroscopic means and X-ray diffraction analysis. 相似文献
10.
《Phytochemistry》1986,25(10):2414-2416
Three trans-clerodane diterpenes were isolated from the aerial part of the Portulaca cv Jewel. Their structures were elucidated by spectroscopic methods and chemical correlations. 相似文献
11.
From the whole plant of Ajuga pseudoiva two epimeric neo-clerodane diterpenoids, 2-acetylivain I and its C-2 epimer 14,15-dihydro-ajugapitin, have been isolated. The structures were established by spectroscopic and chemical means. 2-Acetylivain I had not been previously reported, while its C-2 epimer had been isolated from Ajuga chamaepitys. 相似文献
12.
《Phytochemistry》1987,26(5):1421-1424
The effects of the components of Murashige-Skoog (MS) medium on the production of the diterpenes cryptotanshinone and ferruginol in cell suspension cultures of Salvia miltiorrhiza were examined. Sucrose, a nitrogen source and thiamine were needed for the production of these compounds, and phosphate, MnSO4 and kinetin showed slight beneficial effects. All the other components of MS medium were found to be either unnecessary or inhibitory for the production of these compounds, when tested separately. A revised medium for the production of cryptotanshinone, a clinically active principle in this plant, was designed. 相似文献
13.
Rosa Angela Raccuglia Gabriella Bellone Kristina Loziene Franco Piozzi Sergio Rosselli Antonella Maggio Maurizio Bruno Monique S.J. Simmonds 《Phytochemistry》2010,71(17-18):2087-2091
From the aerial parts of Scutellaria hastifolia, family Lamiaceae (Labiatae), seven neo-clerodane diterpenoids (hastifolins A–G) were isolated. The products are similar to the known scuteparvin and are characterized by being trans-cinnamoyl derivatives. Structures and stereochemistry were determined by intensive NMR investigation. Six of the products form three pairs of epimers at C-13. Hastifolins A–C showed significant antifeedant activity. 相似文献
14.
《Phytochemistry》1987,26(12):3285-3288
From the aerial parts of Teucrium creticum a new neo-clerodane diterpenoid, teucretol, has been isolated, together with the previously known diterpenoids 6,19- diacetylteumassilin, 19-acetylgnaphalin and teucjaponin B. The structure of teucretol, 6,19-diacetoxy-4α,18;15,16-diepoxy-neo-cleroda-13(16),14-diene-12ξ,20-diol, was established by chemical and spectroscopic means. 相似文献
15.
Werner Knöss 《Plant cell reports》1995,14(12):790-793
Summary Callus cultures, cell suspension cultures and shoot cultures of Leonurus cardiaca L. (Motherwort) were established and growth conditions optimized. Shoot cultures showed constant growth whether in the dark or under continuous light, accumulating varying amounts of the furanic labdane diterpenes leosibiricin, preleosibirin, leosibirin and isoballotenol acetate, which are also present in the soil-grown plants. Only traces of leosibiricin were detected in callus cultures, while cell suspension cultures did not produce any furanic diterpenes. A small amount of furanic labdane diterpenes was found in the medium of shoot cultures. Callus and shoot culture induction of several other Lamiaceae species is also described.Abbreviations 2 4-D
2,4-dichlorophenoxyacetic acid
- BAP
benzylaminopurine
- GA3
gibberellic acid
- HPLC
high pressure liquid chromatography
- NAA
naphthyl acetic acid
- TLC
thin layer chromatography 相似文献
16.
17.
The presence of several types of allelochemicals has been reported from Ajuga, a Labiatae genus comprising more than 40 species of wide distribution in extratropical regions of both hemispheres. The
genus is of great medicinal and economic importance and among the biological properties of the secondary metabolites, the
antifeedant activity against pest insects appears to be related to the presence of neo-clerodane type diterpenes. This review focuses on the isolation and structural elucidation of this type of compounds from
Ajuga species and the hemisynthetic compounds of closely related structure obtained. The reported biological activity of crude
extracts and isolated diterpenes will be briefly commented.
相似文献
Josep CollEmail: |
18.
Xiu-Ping Nie Gui-Wu Qu Xi-Dian Yue Gui-Sheng Li Sheng-Jun Dai 《Phytochemistry letters》2010,3(4):190-193
Three new neo-clerodane diterpenoids, named scutelinquanines A–C (1–3), were isolated from the whole plant of Scutellaria barbata. Their structures were established on the basis of detailed spectroscopic analyses. In vitro, the isolated three new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 2.7–6.7 μM. 相似文献
19.
The Camptotheca acuminata cell suspension cultures were established to produce the well-known antitumor monoterpene indole alkaloid camptothecin (CAM). Most CAM was present in the broth of the C. acuminata cell suspension cultures. The CAM production was evidenced to be attenuated when the C. acuminata cell suspension cultures were continuously subcultured and grown under identical axenic conditions. A practical cryopreservation and recovery procedure was established to maintain the C. acuminata cell suspension cultures. Biotic and abiotic elicitors were administrated to the C. acuminata cell suspension cultures to restore and enhance CAM production. Of them, sorbitol, a well-known hyperosmotic stressor, was proven to be the most effective elicitor that stimulates a ~500-fold increase of CAM production. The committed biosynthetic precursors of CAM, tryptamine and secologanin, were feed to the C. acuminata cell suspension cultures and the CAM production is not remarkably increased. However, N 1-acetylkynuramine (NAK), an important metabolite of kynuramine pathway, was isolated and identified from the cell suspension cultures feeding with tryptamine. The present work provides an efficient method to produce CAM and NAK using the C. acuminata cell suspension cultures. The biotransformation of tryptamine to NAK sheds lights on the biosynthetic formation of the pyrroloquinoline moiety of CAM. 相似文献
20.
Bo Wang Xiao-Ning Wang Tao Shen Shu-Qi Wang Dong-Xiao Guo Hong-Xiang Lou 《Phytochemistry letters》2012,5(2):271-275
Four new rearranged abietane diterpenoid hydroquinones, ajudecumins A–D (1–4), together with two known rearranged abietane diterpenoids, three neo-clerodane diterpenoids, four megastigmane derivatives, two flavonoids as well as a bisabolene sesquiterpenoid were isolated from the aerial parts of Ajuga decumbens. Their structures were established on the basis of extensive spectroscopic analysis and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Among the diterpenoids, compounds 1 and 3 exhibited moderate inhibitory activity on the proliferation of human breast cancer MCF-7 cells. 相似文献