Plant development going MADS

It has been known for a decade that the plant MADS genesare important regulators of meristem and floral organ identity. The MADS family in Arabidopsis consists of more than 80 members and, until recently, the function of the majority of these genes was unknown. With the enhanced ability to generate loss-of-function mutants and over-expression lines, the function of the MADS gene family members is beginning to be elucidated. Recent progress demonstrates that MADS genes in Arabidopsis are important regulators not only of meristem and floral organ identity but also of flowering timing and cell-type specification in floral organs.     

Going,going, gone

The decline and loss of species is inevitable in the face of growing human pressures on the environment but, according to one group of senior researchers, a standard framework is needed to assess the rate of this decline if researchers wish to be effective and policymakers are to take note.     

The FADD is going nuclear

Fas-associated death domain protein (FADD) is an adaptor molecule that bridges the interactions between membrane death receptors and initiator caspases. Thus, the site of its action has always been expected to be the cytoplasmic death-inducing signaling complex (DISC). Recent evidence indicates that FADD primarily resides in the nucleus and appears to shuttle between nucleus and cytoplasm. In addition to its well-established role in transduction of apoptotic signals, FADD may also play a role in regulating genome surveillance and perhaps in other as yet unidentified cellular processes.     

Where are we going?

The foregoing study attempts to document the course of the American Society of Plastic and Reconstructive Surgeons, Inc. during the period 1964-1973, inclusive. A special attempt has been made to delineate the current trends. Trends, when recognized, may be enhanced, modified, or prevented-as deemed appropriate by the membership.     

CART trials are going ahead

正For a long time,unresectable tumors were mainly controlled by chemotherapy,radiation therapy or kinase inhibitors,with which complete and durable remission was infrequent despite great advances achieved.Until recently,together with checkpoint inhibitors,chimeric antigen receptor modified T(CART)therapies have made immunotherapy percolated into the mainstream of cancer treatment due to astonishing clinical results.     

Gone, gone and going

Biomedicine swallows the lion's share of life science funding but there is mounting concern that the health of ecosystems should be demanding more attention. Nigel Williams reports.     

Methodology going astray in population biology

This paper analyses the broad methodological structure of population-biological theorising. In it, I show that the distinction between initial exploratory, hypothesis-generating research and the subsequent process-reconstructing, hypothesis-testing type of research is not being made. Rather, the hypotheses generated in population biology are elaborated in such detail that students confound the initial research phase with the subsequent hypotheses-testing phase of research. In this context, I therefore analyse some testing procedures within the exploration phase and show that, as an extreme form of confusion, statistical null-models are mistakenly given the status of causal population-biological theory.     

ATP-dependent chromatin remodeling: going mobile

Members of the ATP-dependent class of chromatin remodeling enzymes are found in all eukaryotes where they play key roles in many DNA-mediated processes. Each of these enzymes are multi-subunit assembles that hydrolyze approximately 1000 ATP/min. The energy of ATP hydrolysis is used to disrupt the chromatin structure which can be scored by enhanced factor binding, disruption of the DNase I cleavage pattern of mononucleosomes, formation of dinucleosomes, movements of histone octamers in cis and in trans, and by generation of nuclease hypersensitive sites. Here the biochemical properties of these enzymes are reviewed and the manner in which ATP-driven nucleosome movements might account for many of these diverse activities is discussed.     

GWAS is going to the dogs

Genome-wide association studies in canine models may help locate genomic susceptibility regions that are relevant to human disease. See related Research: http://genomebiology.com/2014/15/3/R25     

Fast-track cardiology clinics—going Dutch!

Netherlands Heart Journal -