共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
TGF-beta and the Smad signal transduction pathway. 总被引:31,自引:0,他引:31
10.
植物MYB类转录因子研究进展 总被引:23,自引:0,他引:23
植物MYB转录因子以含有保守的MYB结构域为共同特征,广泛参与植物发育和代谢的调节。含单一MYB结构域的MYB转录因子在维持染色体结构和转录调节上发挥着重要作用,是MYB转录因子家族中较为特殊的一类。含两个MYB结构域的MYB转录因子成员众多,在植物体内主要参与次一代谢的调节和控制细胞的形态发生。含3个MYB结构域的MYB蛋白与c-MYB蛋白高度同源,可能在调节细胞周期中起作用。 相似文献
11.
12.
13.
Markus Hafner Klaas E.A. Max Pradeep Bandaru Pavel Morozov Stefanie Gerstberger Miguel Brown Henrik Molina Thomas Tuschl 《RNA (New York, N.Y.)》2013,19(5):613-626
Human LIN28A and LIN28B are RNA-binding proteins (RBPs) conserved in animals with important roles during development and stem cell reprogramming. We used Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) in HEK293 cells and identified a largely overlapping set of ∼3000 mRNAs at ∼9500 sites located in the 3′ UTR and CDS. In vitro and in vivo, LIN28 preferentially bound single-stranded RNA containing a uridine-rich element and one or more flanking guanosines and appeared to be able to disrupt base-pairing to access these elements when embedded in predicted secondary structure. In HEK293 cells, LIN28 protein binding mildly stabilized target mRNAs and increased protein abundance. The top targets were its own mRNAs and those of other RBPs and cell cycle regulators. Alteration of LIN28 protein levels also negatively regulated the abundance of some but not all let-7 miRNA family members, indicating sequence-specific binding of let-7 precursors to LIN28 proteins and competition with cytoplasmic miRNA biogenesis factors. 相似文献
14.
15.
Analysis of the petunia MADS-box transcription factor family 总被引:9,自引:0,他引:9
Immink RG Ferrario S Busscher-Lange J Kooiker M Busscher M Angenent GC 《Molecular genetics and genomics : MGG》2003,268(5):598-606
16.
17.
18.
19.