共查询到20条相似文献,搜索用时 15 毫秒
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Ken-Go Hayashi Koichi Ushizawa Misa Hosoe Toru Takahashi 《Reproductive biology and endocrinology : RB&E》2010,8(1):11
Background
Bovine follicular development is regulated by numerous molecular mechanisms and biological pathways. In this study, we tried to identify differentially expressed genes between largest (F1) and second-largest follicles (F2), and classify them by global gene expression profiling using a combination of microarray and quantitative real-time PCR (QPCR) analysis. The follicular status of F1 and F2 were further evaluated in terms of healthy and atretic conditions by investigating mRNA localization of identified genes. 相似文献2.
Marcela Julio-Pieper Hernán E Lara Javier A Bravo Carmen Romero 《Reproductive biology and endocrinology : RB&E》2006,4(1):57-11
Background
Angiogenesis is a crucial process in follicular development and luteogenesis. The nerve growth factor (NGF) promotes angiogenesis in various tissues. An impaired production of this neurotrophin has been associated with delayed wound healing. A variety of ovarian functions are regulated by NGF, but its effects on ovarian angiogenesis remain unknown. The aim of this study was to elucidate if NGF modulates 1) the amount of follicular blood vessels and 2) ovarian expression of two angiogenic factors: vascular endothelial growth factor (VEGF) and transforming growth factor beta 1 (TGFbeta1), in the rat ovary. 相似文献3.
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Misa Hosoe Kanako Kaneyama Koichi Ushizawa Ken-go Hayashi Toru Takahashi 《Reproductive biology and endocrinology : RB&E》2011,9(1):33
Background
It has been reported that calf oocytes are less developmentally competent than oocytes obtained from adult cows. Bone morphogenetic protein 15 (BMP15) and growth and differentiation factor 9 (GDF9) play critical roles in folliculogenesis, follicular development and ovulation in mammalian ovaries. In the present study, we attempted to compare the expression patterns of BMP15 and GDF9 in the cells of calf and cow ovaries to determine a relationship between the level of these genes and the low developmental competence of calf oocytes. 相似文献5.
Rafael T Mikolajczyk Joseph B Stanford René Ecochard 《Reproductive biology and endocrinology : RB&E》2008,6(1):61
Background
To assess the amount of variability in ovarian follicular growth rate and maximum follicular diameter related to different centers, women and cycles of the same women in a multicenter observational study of follicular growth. 相似文献6.
Eric Acuña Romina Fornes Daniela Fernandois Maritza P Garrido Monika Greiner Hernan E Lara Alfonso H Paredes 《Reproductive biology and endocrinology : RB&E》2009,7(1):64-13
Background
Depletion of ovarian follicles is associated with the end of reproductive function in ageing females. Recently, it has been described that this process parallels increases in the concentration of norepinephrine (NE) in the rat ovary. In sexually mature rats, experimentally-induced increases in the sympathetic tone of the ovary is causally related to ovarian cyst formation and deranged follicular development. Thus, there is a possibility that increased ovarian NE concentrations represent changes in the activity of sympathetic nerves, which consequently participate in the process of ovarian cyst formation observed during ageing in the human and experimental animal models. 相似文献7.
Somayyeh Fahiminiya Valérie Labas Sylvie Chastant-Maillard Nadine Gérard 《Reproductive biology and endocrinology : RB&E》2010,8(1):132
Background
Follicular fluid contains substances involved in follicle activity, cell differentiation and oocyte maturation. Studies of its components may contribute to better understanding of the mechanisms underlying follicular development and oocyte quality. The canine species is characterized by several ovarian activity features that are not extensively described such as preovulatory luteinization, oocyte ovulated at the GV stage (prophase 1) and poly-oocytic follicles. In this study, we examined the hypothesis that the preovulatory LH surge is associated with changes in steroid and protein content of canine follicular fluid prior to ovulation. 相似文献8.
Background
The objective of this study was to identify substantially increased proteins in bovine cystic follicular fluid (FF) in order to clarify the pathology and etiology of bovine ovarian follicular cysts (BOFC). 相似文献9.
Jean M Feugang Jonathan M Greene Scott T Willard Peter L Ryan 《Reproductive biology and endocrinology : RB&E》2011,9(1):15
Background
Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined. Here, we investigated the effects of porcine relaxin during oocyte maturation and embryo development, and gene expression in the pig. 相似文献10.
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Background
Molecular cloning of functional immunoglobulin genes from single plasma cells is one of the most promising technologies for the rapid development of monoclonal antibody drugs. However, the proper insertion of PCR-amplified immunoglobulin genes into expression vectors remains an obstacle to the high-throughput production of recombinant monoclonal antibodies. 相似文献13.
Background
During the female reproductive cycle, follicular development and corpus luteum formation crucially depend on the fast generation of new blood vessels. The importance of granulosa cells and follicular fluid in controlling this angiogenesis is still not completely understood. Vascular endothelial growth factor (VEGF) produced by granulosa cells and secreted into the follicular fluid plays an essential role in this process. On the other hand, soluble VEGF receptor-1 (sFlt-1) produced by endothelial cells acts as a negative modulator for the bioavailability of VEGF. However, the regulation of sFlt-1 production remains to be determined. 相似文献14.
Jochen Blom Stefan P Albaum Daniel Doppmeier Alfred Pühler Frank-J?rg Vorh?lter Martha Zakrzewski Alexander Goesmann 《BMC bioinformatics》2009,10(1):154
Background
The introduction of next generation sequencing approaches has caused a rapid increase in the number of completely sequenced genomes. As one result of this development, it is now feasible to analyze large groups of related genomes in a comparative approach. A main task in comparative genomics is the identification of orthologous genes in different genomes and the classification of genes as core genes or singletons. 相似文献15.
Background
Drought is one of the major abiotic stresses affecting plant growth, development and crop productivity. ABA responsive element binding factor (ABF) plays an important role in stress responses via regulating the expression of stress-responsive genes. 相似文献16.
Reza Mobini Bengt A Andersson Jonas Erjefält Mirjana Hahn-Zoric Michael A Langston Andy D Perkins Lars Olaf Cardell Mikael Benson 《BMC systems biology》2009,3(1):19-11
Background
The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes. 相似文献17.
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Stephen C Billups Margaret C Neville Michael Rudolph Weston Porter Pepper Schedin 《BMC bioinformatics》2009,10(1):96
Background
An important component of time course microarray studies is the identification of genes that demonstrate significant time-dependent variation in their expression levels. Until recently, available methods for performing such significance tests required replicates of individual time points. This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected. 相似文献20.
Zheng Li-Ping Zhang Da-Lei Huang Jian Xu Liang-Quan Xu Ai-Xia Du Xiao-Yu Tang Dan-Feng Zheng Yue-Hui 《Reproductive biology and endocrinology : RB&E》2010,8(1):66