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1.
Ivor E. Dreosti Reginald A. Buckley Ian R. Record 《Biological trace element research》1980,2(1):31-39
Studies performed on adult female rats over a period of 10 weeks indicated that the consumption of alcohol (20% v/v) did not
appear to disturb the zinc or copper balance, nor did it adversely affect tissue zinc or copper levels, even in zinc-restricted
animals. On the contrary, higher plasma zinc levels were consistently observed in animals receiving alcohol together with
the experimental diets. 相似文献
2.
Olusi S Al-Awadhi A Abiaka C Abraham M George S 《Biological trace element research》2003,91(2):137-144
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there
are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated
the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older.
Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured
by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=−0.423, p<0.001). There was no significant association between serum leptin and zinc (r=−0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with
serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=−0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels. 相似文献
3.
Jana Kadrabová Alexander Madáriĉ Mária Šustrová Emil Ginter 《Biological trace element research》1996,54(3):201-206
Being cofactors of important antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), which are significantly
modified in Down's syndrome (trisomy 21), serum levels of microtrace elements zinc, copper, and selenium and of macroelement
magnesium are reported in 16 subjects with Down's syndrome (DS) and their respective well age- and sex-matched controls. Serum
zinc and selenium levels were significantly lowered in DS subjects, whereas copper levels were elevated. Consequently, a marked
increase (40%) of the copper/zinc ratio in DS persons was observed. There were no differences in serum levels of magnesium
between DS and control subjects. 相似文献
4.
The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian Cohort 总被引:1,自引:0,他引:1
M. Ghayour-Mobarhan A. Shapouri-Moghaddam M. Azimi-Nezhad H. Esmaeili S.M.R. Parizadeh M. Safarian S.M.R. Kazemi-Bajestani G.H. Khodaei S.J. Hosseini S.M.J. Parizadeh G.A. Ferns 《Journal of trace elements in medicine and biology》2009,23(3):167-175
IntroductionThe relationship between demographic and biochemical characteristics, including several established coronary risk factors, and serum copper and zinc was assessed in a large Iranian population sample.Materials and methodsA group of 2233 individuals, 15–65 years of age [1106 (49.5%) males and 1127 (50.5%) females] was recruited from residents of the Greater Khorasan province in northeast of Iran. Demographic data were collected using questionnaires. Coronary risk factors were determined using standard protocols, and trace elements were measured in serum using atomic absorption spectroscopy.ResultsDegree of glucose tolerance and smoking habit were not associated with serum zinc and copper levels. Serum copper levels were significantly higher in obese and hypertensive than in normal subjects (p<0.001). In the whole group and for the female subgroup, serum zinc (p<0.01) and copper (p<0.001) were both significantly lower in individuals with normal versus high levels of low-density lipoprotein cholesterol.A strong positive correlation was found between serum copper and body mass index (BMI) (r=0.85, p<0.001). Weaker positive associations were found between serum copper and calculated 10 years’ coronary risk (r=0.11, p<0.001). Serum zinc/copper ratio was strongly inversely associated with calculated 10 years’ coronary risk (r=?0.10, p<0.001). The partial Eta squared (PES) values for factors determining serum zinc were hypertension (0.007, p=0.01) and BMI (0.004, p=0.01); and for serum copper, they were gender (0.02, p=0.001), hypertension (0.004, p=0.009), and 10 years’ coronary risk for men (0.003, p=0.03) and women (0.002, p=0.07).ConclusionSignificant associations between serum trace element concentrations and several coronary risk factors, including calculated 10 years’ coronary risk scores, were found. 相似文献
5.
Mark P. Richards 《Biological trace element research》1999,69(1):27-44
Zinc, copper, and iron levels in maternal and fetal pig tissues and fluids were measured starting on d 30 of gestation and
continuing to term (d 114) at 10-d intervals. Fetal hematocrit increased from a low of 19% on d 30 to 32% by d 50, after which
it remained above 30% to term. Amniotic fluid zinc, copper, and iron all reached maximal levels by d 60 of gestation. Maternal
serum zinc levels fluctuated little during gestation, but fetal serum zinc concentration was significantly elevated above
maternal levels during the second trimester. Fetal serum copper levels were significantly lower than maternal values throughout
gestation and this was also the case for ceruloplasmin oxidase activity. Maternal serum iron reached its lowest level by d
80 of gestation when rate of transfer of iron to the developing fetuses was high. Fetal serum iron declined throughout gestation,
reaching its lowest level on d 100. In general, fetal liver concentrations of zinc, copper, and iron were higher than the
corresponding maternal values throughout gestation. Distinct increases were noted for fetal hepatic zinc and copper concentrations
during the second trimester of pregnancy and these were accompanied by increases in cytosolic and metallothionein-bound zinc
and copper levels. Maternal hepatic iron declined during the second trimester, reaching its lowest point on d 80, indicative
of the shunting of maternal iron reserves to fetal tissues. Fetal kidney metal levels did not demonstrate any distinctive
developmental patterns with respect to zinc, copper, or iron concentrations, but a general accumulation of each metal was
observed as gestation progressed. The results of this study highlight some of the distinct changes occurring in the metabolism
of zinc, copper, and iron in both maternal and fetal tissues and fluids during gestation in the pig.
Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee or warranty by the U.S.
Department of Agriculture and does not imply its approval to the exclusion of other suitable products. 相似文献
6.
Pasa S Kargin F Bildik A Seyrek K Ozbel Y Ozensoy S 《Biological trace element research》2003,94(2):141-147
The aim of this study was to determine the zinc, iron, copper, calcium, phosphorus, and magnesium levels in blood serum and
zinc and copper levels in hair of dogs with canine visceral leishmaniasis. The serum zinc and iron levels were found to be
significantly lower in diseased dogs than those of healthy controls. Serum copper levels were significantly higher, whereas
no significant differences were observed for calcium, phosphorus, and magnesium. There were no significant differences in
the zinc and copper levels in hair. Our results show that the serum zinc, iron, and copper levels are altered in canine leishmaniasis. 相似文献
7.
Arora R Kulshreshtha S Mohan G Singh M Sharma P 《Biological trace element research》2006,114(1-3):121-126
Diarrhea is, in reality, as much a nutritional disease as one of fluid and electrolyte loss. Children who die from diarrhea,
despite good management of dehydration, are usually malnourished and often severely so. In this study, we determined the serum
levels of zinc and copper before and after standard oral rehydration solution (ORS) therapy in children with acute diarrhea
and correlated it with diarrheal duration and severity. One hundred ten children suffering from acute diarrhea were included.
Serum zinc and copper levels of these children were estimated at the time of enrollment and after treatment with standard
ORS therapy. This study shows that children suffering from acute diarrhea show a statistically significant decrease of 13.1%
and 12.8% in serum zinc and copper concentrations, respectively, compared to normal. These levels further decrease by 22.6%
and 22.4%, respectively, after treatment with standard ORS therapy. Our study shows that children with the lower plasma zinc
and copper levels suffered with more severe and longer duration of diarrhea. Zinc and copper supplementation could be added
to standard ORS therapy for the reduction in morbidity and mortality associated with acute diarrhea in children. 相似文献
8.
Lopes PA Santos MC Vicente L Rodrigues MO Pavão ML Nève J Viegas-Crespo AM 《Biological trace element research》2004,100(1):1-17
Serum levels of selenium, copper, and zinc were systematically determined in healthy subjects of the Lisbon population. The
sample consisted of 183 blood donors of both genders who were divided into two age groups: 20–44 and 45–70 yr of age; relationships
with gender, age, the lipid profile, and tobacco consumption were investigated. In the female group, the intake of oral contraceptives
and pregnancy were considered for the youngest women, and hormonal replacement therapy (HRT) was taken into account for the
oldest ones. Serum concentrations of these elements were in the same range as those found for populations of other European
countries. Differences between genders were observed for the three elements studied, with serum selenium and zinc concentrations
higher in men and copper levels higher in women. Age-dependent differences were found for selenium: The oldest subjects (regardless
gender) presented the highest concentrations of selenium in serum as further demonstrated by the positive correlation with
age. In both pregnant and contraceptive-using women, copper was greatly increased, confirming the influence of estrogen status
and/or oral contraceptive intake on increased serum copper levels. However, in postmenopausal women, HRT did not significantly
affect serum copper levels. Selenium, copper, and zinc status were not different between normolipidemic and hyperlipidemic
subjects for the same gender and age range, but selenium levels tended to increase with hyperlipidemia when considering the
whole group of subjects. With respect to the lifestyle, higher serum zinc levels were found in tobacco-consuming men. Albumin
serum levels were similar for all considered subgroups, except for the pregnant women, for whom a decrease in this parameter
was observed. The present study allowed one to obtain reference values for this healthy group of population, which will serve
for a comparative study with groups having pathological conditions, such as cardiovascular disease. 相似文献
9.
Two-wk-old broiler chicks were inoculated via crop intubation withEimeria acervulina at two doses: 105 or 106 sporulated oocysts/bird or withEimeria tenella at a dose of 105 sporulated oocysts/bird. Serum and liver samples were collected on days 3 and 6 post-inoculation (PI). There were no significant
changes in serum or liver zinc, copper, and iron concentrations in any of the infected groups by 3 d PI. However, on d 6,
PI serum protein was significantly reduced in all of the infected groups compared to their pair-fed controls. The chicks infected
withE. tennella had significantly reduced serum zinc (1.20 vs 1.77 μg/mL) and iron (0.44 vs 1.28 μg/mL) concentrations and significantly
elevated serum copper (0.28 vs 0.17 μg/mL) and ceruloplasmin levels (20.33 vs 11.11 μg/mL) compared to their pair-fed counterparts.
Those chicks infected withE. acervulina (106 oocysts/bird) exhibited significantly reduced serum iron concentration by 6 days PI (0.90 vs 1.14 μg/mL). Liver zinc was
significantly increased in the chicks infected withE. tenella (349 vs 113 μg/g dry liver wt), as was copper (24 vs 19 μg/g), whereas liver iron concentration was significantly reduced
(172 vs 243 μg/g) compared to pair-fed controls. At both dose levels, the chicks infected withE. acervulina exhibited a significant reduction in liver iron by 6 d PI. Hepatic cytosol metals generally reflected whole tissue levels.
Metallothionein (MT)-bound zinc was significantly elevated in the chicks infected withE. tenella. Iron bound to a high molecular weight, heat-stable protein fraction (presumably cytoplasmic ferritin) was significantly
reduced in chicks infected withE. acervulina, as well as those infected withE. tenella. Collectively, the changes in serum zinc, copper, and iron concentrations, as well as the changes in hepatic zinc and MT-zinc
concentrations in the chicks infected withE. tenella were similar to changes evoked during an acute phase response to infection. It is possible that a secondary bacterial infection
or inflammation stemming from erosion of the lining of the cecum may play a role in the response of trace element metabolism
to theE. tenella infection.
Mentions of a trademarkr, proprietary product or specific equipment does not consitute a guarantee or warranty by the US Department
of Agriculture and does not imply its approval to the exclusion of other products. 相似文献
10.
Hair zinc and copper: Relationship to hair type and serum concentrations in children and adolescents
The zinc and copper serum and hair concentrations of 691 3-18-y-old girls and boys previously determined as a part of the
Multicentre Study of Atherosclerosis Precursors in Finnish Children and Adolescents were further analyzed in order to find
a possible association between these two zinc and copper indices. The influence of hair color and the diameter of individual
hair strands on hair concentrations were studied by the analysis of covariance. Hair color and serum zinc concentrations were
found to be associated with hair zinc concentrations in boys. Such an association was not found for zinc and copper concentrations
in girls. Hair vs serum concentrations in different age and hair color groups did not show however, a significant relationship
either in copper or in zinc concentrations. The subjects with very low or high serum zinc or copper concentrations did not
usually have extreme hair concentrations and vice versa. However, there were some subjects with low or high serum concentrations
associated with low or high hair concentrations. 相似文献
11.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献
12.
Cunzhi Han Jiexian Jing Xianwen Zhao Jingang Guo Suling Hou 《Biological trace element research》2001,83(2):133-138
The serum copper and zinc levels were determined by atomic absorption spectrometry in 135 Hodgkin's disease (HD) patients and in 100 healthy controls. These values were used to explore the application value of the serum copper/zinc ratio in the histologic classification and prognosis in this illness. The resuls show that serum copper and the copper/zinc ratio were higher and the serum zinc level was lower in the HD patients when compared to the healthy individuals (p < 0.01, 0.001, and 0.01, respectively). The serum copper and copper/zinc ratio were significantly higher in the lymphocyte-depleted type of HD than in the patients with the mixed-cellular type of HD. These values were also higher and the serum zinc was lower in the patients with mixed-cellular HD when compared to the nodular-sclerosis and the lymphocyte-predominant types of the disease (p < 0.01 and 0.001, respectively). It was also shown that as the disease progresses, the serum copper level and copper/zinc ratio rises with the concomitant decrease of the corresponding serum zinc level. These trends are reversed in cases where the disease is in remission. Both the serum copper level and the copper/zinc ratio were strongly correlated to histopathological changes, clinical stage, and prognosis of Hodgkin's disease. 相似文献
13.
Tatari H Işlekel H Altekin E Göçen S Ozcan C Ergör A 《Biological trace element research》2001,80(1):33-42
Changes in serum magnesium, copper and zinc values were evaluated in spinal fusion patients at four monitorings. For magnesium
and copper individually, a significant difference was found between the mean values at each monitoring (p<0.05), whereas the changes of zinc values between four monitorings were insignificant. There was no statistical difference
between the changes of each trace element values and gender, age, operative time, intraoperative blood loss, blood replacement,
number of the vertebral levels fused, and antibiotic type used.
As a result, magnesium can be suggested to be more important than the other two elements in the postoperative period. Alterations
of serum magnesium, copper, and zinc values do not have any correlation with the fusion of the spinal column, either with
the width of the fused area or operative time and blood loss. This study cannot confirm the exact reason for this entity and
the etiology remains speculative. There is no need for magnesium, copper, or zinc supplementation during the surgical period
for the patients. It will be worthy to evaluate the patients who were sent to the intensive care unit after spinal surgery
and compare their results with the other intensive care patients. 相似文献
14.
The hypothesis that in tumor-bearing animals an increase of host hepatic zinc metallothionein (Zn-MT) causes a restriction
of zinc in the tumor tissue was studied.
Three types of tumors were induced in laboratory mice by cell transplant. Tumor growth appears to be inhibited under zinc-deficient
conditions, even in cases where zinc deficiency was started after tumor cell transplant.
The survival times of tumor-bearing mice were prolonged by administration of cadmium chloride, which induces the synthesis
of a combined zinc-cadmium metallothionein derivative in the host liver, but not in the tumor tissue, leading to an increase
of hepatic zinc in the treated animals. The uptake of65Zn by the liver of Cd-treated, tumor bearing mice was significantly higher than that of controls whereas uptake of65Zn by tumor cells was significantly higher in controls than in the treated animals.
These results suggest that restriction of zinc intake suppresses tumor growth. 相似文献
15.
The precise nature of the variation in cellular copper load against medium copper concentration is defined using a comprehensive logarithmically incremented series of medium copper concentrations ranging from low levels (4.8 p.p.b.) through normal to toxic levels (40 p.p.m.) in which fibroblasts were grown followed by determination of intracellular content. Menkes' fibroblasts showed an unexpected plateau region of stable intracellular copper content against a change in medium concentration of over 100-fold, albeit only when sufficient copper was present in the medium (0.08–8.0 p.p.m.). Thus, Menkes' cells are clearly capable of balancing uptake/efflux providing copper availability allows. Simultaneous analysis of cellular copper and zinc load at various medium copper concentrations shows an indistinguishable intracellular copper:zinc ratio between the two cell lines. The nature of non-labeled copper uptake by fibroblasts over a 40 min and 7 day period is reported. During the 40 min period copper uptake (20 p.p.m.) was essentially the same in both cell lines. However, copper absorbed was superimposed upon large pre-existing copper pools in the case of Menkes' cells only. Advantages of techniques determining non-labeled copper in copper uptake/efflux experiments are discussed in the light of these results. Fibroblast growth studies showed that, compared with normal cells, Menkes' cells are significantly (P < 0.01) more growth sensitive to extended exposure to low copper concentrations. Thus, Menkes' disease appears to be not only a result of copper maldistribution but also a direct result of an inability of Menkes' cells to function normally in low copper environments. 相似文献
16.
Jacobus P. Van Wouwe Stephanie Hoogenkamp Cornelis J. A. Van den Hamer 《Biological trace element research》1991,29(3):175-180
In fetus with a mean gestational age of 18 weeks (range 15-25, n = 14), zinc and copper concentrations in liver, femur, rib, and skeletal muscle were measured. Zinc and copper concentrations are highest in liver. A trend of decreasing liver zinc concentrations during gestational age is suggested. Zinc concentrations are significantly correlated with copper concentrations in liver and in femur, suggesting steady growth in both organs. Femur zinc values rank ca. 30% of those in liver, femur copper, ca. 2%. Zinc or copper concentrations in rib are of the same levels as in skeletal muscle. Their concentration for zinc ranks ca. 20%, for copper, ca. 5% of the values in liver. All zinc and copper values are lower than reported in third trimester fetal organs. Calculated zinc/copper molar ratios are distinctive for the various organs: in liver, 6 +/- 1, in femur, 73 +/- 8, and in soft tissues, 26 +/- 3. Calculated ratios from published values obtained from the third trimester of pregnancy show that the ratios in liver and skeletal muscle maintain these levels. The zinc/copper molar ratio can serve as an internal reference in zinc and/or copper measurements. 相似文献
17.
H. G. Petering E. Giroux H. Choudhury E. E. Menden 《Biological trace element research》1982,4(2-3):221-232
Rats were fed a purified egg white-based diet containing 5 ppm Cu and 2, 14, or 57 ppm Zn. Zinc and copper balances were determined
for eight consecutive weekly trial periods. The zinc-deficient group almost ceased to gain weight and was in slightly negative
zinc balance. Groups of rats fed 14 and 57 ppm Zn gained weight at equal rates. These groups were in strongly positive zinc
balance for four weeks; thereafter, they fed 57 ppm Zn retained about two times as much zinc as did the group fed the diet
containing 14 ppm Zn. All groups were in null or slightly negative copper balance throughout the trial. These results suggest
that zinc accumulation may be homeostatically controlled to a level in excess of that needed for maximum growth. 相似文献
18.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
19.
J. Brandao Neto J. G. H. Vieira T. Shuhama E. M. K. Russo R. V. Piesco P. R. Curi 《Biological trace element research》1991,28(2):123-133
Reports in the literature have shown that acute or chronic zinc administration may cause hyperglycemia, with a fall in serum
or insular insulin occurring in experimental animals. On the other hand, under conditions of both acute and chronic hyperglycemia,
an increase, a decrease, or a normal level of blood zinc has been observed in studies conducted on humans. Thus, the objective
of the investigation described here was to determine the relationship existing among zinc, glucose, and insulin under acute
conditions. Thirty-six subjects of both sexes (mean age, 23 yr) were tested at 7:00A.M. after a 12-h fast. Two antecubital veins of both forearms were punctured and maintained with physiological saline. Three
experiments were performed in which zinc was administered orally, and hypertonic glucose and tolbutamid were administered
intravenously. Blood samples were then collected over a period ranging from 93 to 240 min after the basal times of −30 and
0 min. Hyperzincemia did not cause changes in plasma glucose or insulin either in the absence of or during perfusion of glucose.
Hyperglycemia, hypoglycemia, and hyperinsulinemia did not modify serum zinc levels. These results demonstrate that acute zinc
administration did not change carbohydrate metabolism and that sudden variations in glucose and insulin levels did not modify
the serum profile of zinc. 相似文献
20.
X-ray fluorescence spectrometry and atomic absorption spectrometry were used in a quantitative study of zinc, copper, and
magnesium in 71 postmortal human hearts. Samples were obtained from individuals who had demonstrated no previous clinical
or subsequent pathological findings of myocardial infarction and from victims of a recent or an old infarction. A significant
difference (p<0.001) in the elemental levels was observed between the noninfarct and the recent infarct groups. The noninfarct group had
higher cardiac levels of all three elements. However, the difference in elemental concentrations between the noninfarct and
the old-infarct groups was not significant. Cardiac levels of zinc (p<0.001) and copper (p<0.01) were significantly greater in the old-infarct group than in the recent-infarct group. Magnesium levels were higher
in the recent-and-old-infarct group than in the recent infarct group (p<0.01). It is possible that the elements are redistributed during myocardial infarction, and that uptake of these elements
(from the serum pool) by the heart may be important in maintaining myocardial integrity and function. 相似文献