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《Cellular signalling》2014,26(5):1075-1081
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E2F7 and E2F8 keep the E2F family in balance 总被引:1,自引:0,他引:1
An article by Li and colleagues (in this issue of Developmental Cell) shows that the atypical E2Fs, E2F7 and E2F8, are critical for mouse development. One of the important functions of these family members stems from a negative feedback loop in which E2F7 and E2F8 limit the expression of E2F1 and prevent E2F1-dependent apoptosis. 相似文献
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Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2 总被引:1,自引:0,他引:1 下载免费PDF全文
Sáenz-Robles MT Markovics JA Chong JL Opavsky R Whitehead RH Leone G Pipas JM 《Journal of virology》2007,81(23):13191-13199
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DNA-damage response control of E2F7 and E2F8 总被引:2,自引:0,他引:2
Zalmas LP Zhao X Graham AL Fisher R Reilly C Coutts AS La Thangue NB 《EMBO reports》2008,9(3):252-259
Here, we report that the two recently identified E2F subunits, E2F7 and E2F8, are induced in cells treated with DNA-damaging agents where they have an important role in dictating the outcome of the DNA-damage response. The DNA-damage-dependent induction coincides with the binding of E2F7 and E2F8 to the promoters of certain E2F-responsive genes, most notably that of the E2F1 gene, in which E2F7 and E2F8 coexist in a DNA-binding complex. As a consequence, E2F7 and E2F8 repress E2F target genes, such as E2F1, and reducing the level of each subunit results in an increase in E2F1 expression and activity. Importantly, depletion of either E2F7 or E2F8 prevents the cell-cycle effects that occur in response to DNA damage. Thus, E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response. E2F7 and E2F8, therefore, underpin the DNA-damage response. 相似文献