共查询到20条相似文献,搜索用时 15 毫秒
1.
Storey JD Madeoy J Strout JL Wurfel M Ronald J Akey JM 《American journal of human genetics》2007,80(3):502-509
Understanding patterns of gene-expression variation within and among human populations will provide important insights into the molecular basis of phenotypic diversity and the interpretation of patterns of expression variation in disease. However, little is known about how gene-expression variation is apportioned within and among human populations. Here, we characterize patterns of natural gene-expression variation in 16 individuals of European and African ancestry. We find extensive variation in gene-expression levels and estimate that approximately 83% of genes are differentially expressed among individuals and that approximately 17% of genes are differentially expressed among populations. By decomposing total gene-expression variation into within- versus among-population components, we find that most expression variation is due to variation among individuals rather than among populations, which parallels observations of extant patterns of human genetic variation. Finally, we performed allele-specific quantitative polymerase chain reaction to demonstrate that cis-regulatory variation in the lymphocyte adaptor protein (SH2B adapter protein 3) contributes to differential expression between European and African samples. These results provide the first insight into how human population structure manifests itself in gene-expression levels and will help guide the search for regulatory quantitative trait loci. 相似文献
2.
Multi-stage chemostat investigation of interspecies interactions in a hexanoate-catabolizing microbial association isolated from anoxic landfill 总被引:1,自引:0,他引:1
Spatial separations of physico-chemical environments (habitat domains) with maintenance of overlapping zones of influence (activity domains) with multi-stage chemostat models were used to facilitate examination of interspecies interactions within a hexanoate-catabolizing microbial association isolated from anoxic landfill. Under a constant dilution rate regime, in the presence of 1.4 and 5 mmol/l influent sulphate, consolidation of the major metabolic events of hexanoate catabolism, sulphate reduction, acetogenesis and methanogenesis took place in the first vessel of a five-vessel array suggesting considerable overlap of activity domains or localization around the habitat domains. Evidence of partial competitive displacement was not apparent until 10 mmol/l of sulphate was used. Introduction of a non-constant dilution rate regime to a three-vessel model, subjected to an influent sulphate concentration of 1.4 mmol/l, effected the displacement of the methanogenic species and, as a consequence, in the presence of sulphate limitation, CO2 reduction became the major sink for excess electrons generated from hexanoate oxidation. A hypothetical scheme of anaerobic hexanoate catabolism by the interacting microbial association was developed. 相似文献
3.
The complex vertebrate nervous system has evolved from a simpler nervous system such as that seen in present-day protochordates. Through a recent accumulation of gene-expression data, together with fine anatomical studies, we are now able to identify both how the neural tube was patterned when it first evolved and what is truly novel in the vertebrate neural tube. We are entering a new era in the understanding of how the evolution of novel vertebrate structures is linked to genetic evolution. 相似文献
4.
Studies of spatial variation in the environment have primarily focused on how genetic variation can be maintained. Many one-locus genetic models have addressed this issue, but, for several reasons, these models are not directly applicable to quantitative (polygenic) traits. One reason is that for continuously varying characters, the evolution of the mean phenotype expressed in different environments (the norm of reaction) is also of interest. Our quantitative genetic models describe the evolution of phenotypic response to the environment, also known as phenotypic plasticity (Gause, 1947), and illustrate how the norm of reaction (Schmalhausen, 1949) can be shaped by selection. These models utilize the statistical relationship which exists between genotype-environment interaction and genetic correlation to describe evolution of the mean phenotype under soft and hard selection in coarse-grained environments. Just as genetic correlations among characters within a single environment can constrain the response to simultaneous selection, so can a genetic correlation between states of a character which are expressed in two environments. Unless the genetic correlation across environments is ± 1, polygenic variation is exhausted, or there is a cost to plasticity, panmictic populations under a bivariate fitness function will eventually attain the optimum mean phenotype for a given character in each environment. However, very high positive or negative correlations can substantially slow the rate of evolution and may produce temporary maladaptation in one environment before the optimum joint phenotype is finally attained. Evolutionary trajectories under hard and soft selection can differ: in hard selection, the environments with the highest initial mean fitness contribute most individuals to the mating pool. In both hard and soft selection, evolution toward the optimum in a rare environment is much slower than it is in a common one. A subdivided population model reveals that migration restriction can facilitate local adaptation. However, unless there is no migration or one of the special cases discussed for panmictic populations holds, no geographical variation in the norm of reaction will be maintained at equilibrium. Implications of these results for the interpretation of spatial patterns of phenotypic variation in natural populations are discussed. 相似文献
5.
We study a class of genetic models in which a quantitative trait determined by several additive loci is subject to temporally fluctuating selection. Selection on the trait is assumed to be stabilizing but with an optimum that varies periodically and might be perturbed stochastically. The population mates at random, is infinitely large and has discrete generations. We pursue a statistical and numerical approach, covering a wide range of ecological and genetic parameters, to determine the potential of fluctuating environments to maintain quantitative genetic variation. Whereas, in contrast to some recent claims, this potential seems to be rather limited in the absence of recurrent mutation, fluctuating environments might, in combination with it, often generate high levels of additive genetic variation. We investigate how the genetic variation maintained depends on the ecological parameters and on the underlying genetics. 相似文献
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Wilson AJ Pemberton JM Pilkington JG Coltman DW Mifsud DV Clutton-Brock TH Kruuk LE 《PLoS biology》2006,4(7):e216
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable environments. Here, we applied a novel analytical technique to a long-term study of birthweight in wild sheep and examined, for the first time, how variation in environmental quality simultaneously influences the strength of natural selection and the genetic basis of trait variability. In addition to demonstrating that selection and genetic variance vary dramatically across environments, our results show that environmental heterogeneity induces a negative correlation between these two parameters. Harsh environmental conditions were associated with strong selection for increased birthweight but low genetic variance, and vice versa. Consequently, the potential for microevolution in this population is constrained by either a lack of heritable variation (in poor environments) or by a reduced strength of selection (in good environments). More generally, environmental dependence of this nature may act to limit rates of evolution, maintain genetic variance, and favour phenotypic stasis in many natural systems. Assumptions of environmental constancy are likely to be violated in natural systems, and failure to acknowledge this may generate highly misleading expectations for phenotypic microevolution. 相似文献
8.
Evolution in heterogeneous environments and the potential of maintenance of genetic variation in traits of adaptive significance 总被引:1,自引:0,他引:1
Byers DL 《Genetica》2005,123(1-2):107-124
The maintenance of genetic variation in traits of adaptive significance has been a major dilemma of evolutionary biology. Considering the pattern of increased genetic variation associated with environmental clines and heterogeneous environments, selection in heterogeneous environments has been proposed to facilitate the maintenance of genetic variation. Some models examining whether genetic variation can be maintained, in heterogeneous environments are reviewed. Genetic mechanisms that constrain evolution in quantitative genetic traits indicate that genetic variation can be maintained but when is not clear. Furthermore, no comprehensive models have been developed, likely due to the genetic and environmental complexity of this issue. Therefore, I have suggested two empirical approaches to provide insight for future theoretical and empirical research. Traditional path analysis has been a very powerful approach for understanding phenotypic selection. However, it requires substantial information on the biology of the study system to construct a causal model and alternatives. Exploratory path analysis is a data driven approach that uses the statistical relationships in the data to construct a set of models. For example, it can be used for understanding phenotypic selection in different environments, where there is no prior information to develop path models in the different environments. Data from Brassica rapa grown in different nutrients indicated that selection changed in the different environments. Experimental evolutionary studies will provide direct tests as to when genetic variation is maintained. 相似文献
9.
Several recent microarray studies have compared gene-expression patterns n humans, chimpanzees and other non-human primates to identify evolutionary changes that contribute to the distinctive cognitive and behavioural characteristics of humans. These studies support the surprising conclusion that the evolution of the human brain involved an upregulation of gene expression relative to non-human primates, a finding that could be relevant to understanding human cerebral physiology and function. These results show how genetic and genomic methods can shed light on the basis of human neural and cognitive specializations, and have important implications for neuroscience, anthropology and medicine. 相似文献
10.
Digital models of organs, cells and subcellular structures have become important tools in biological and medical research. Reaching far beyond their traditional widespread use as didactic tools, computer-generated models serve as electronic atlases to identify specific elements in complex patterns, and as analytical tools that reveal relationships between such pattern elements that would remain obscure in two-dimensional sections. Digital models also offer the unique opportunity to store and display gene-expression patterns, and pilot studies have been made in several genetic model organisms, including mouse, Drosophila and Caenorhabditis elegans, to construct digital graphic databases intended as repositories for gene-expression data. 相似文献
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Selecting models to predict the timing of flowering of temperate trees: implications for tree phenology modelling 总被引:7,自引:0,他引:7
Classical budburst models (Spring Warming, Sequential, Parallel and Alternating) are unable to fully predict external data, partly because of the methods of optimization used to adjust them. The purpose of this study was to examine different assumptions of budburst models and select those which are best supported by the data, defining new models able to predict external data. Eight models, each differing in one assumption, were fitted and tested using external data. The dataset used to test the models was deduced from aeropalynological data at two stations in France. The results show that some of the models proposed are able to accurately predict external dates of flowering of most of the studied species. The assumptions of those models have been individually tested and shown to improve the models accuracy. Robust estimates of the best predictor models of 12 tree species are presented. The analysis of hypothetical provenance transfer of two species, Buxus sempervirens and Platanus acerifolia, between the two study sites, shows that P. acerifolia estimates are similar in both environments whereas B. sempervirens estimates are variable. This result, which agrees with the genetic characteristics of both species, shows that local adaptation of phenology can also be studied through modelling approaches. 相似文献
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John R. Stinchcombe Rima Izem M. Shane Heschel Brechann V. McGoey Johanna Schmitt 《Evolution; international journal of organic evolution》2010,64(10):2887-2903
Trade‐offs can exist within and across environments, and constrain evolutionary trajectories. To examine the effects of competition and resource availability on trade‐offs, we grew individuals of recombinant inbred lines of Impatiens capensis in a factorial combination of five densities with two light environments (full light and neutral shade) and used a Bayesian logistic growth analysis to estimate intrinsic growth rates. To estimate across‐environment constraints, we developed a variance decomposition approach to principal components analysis, which accounted for sample size, model‐fitting, and within‐RIL variation prior to eigenanalysis. We detected negative across‐environment genetic covariances in intrinsic growth rates, although only under full‐light. To evaluate the potential importance of these covariances, we surveyed natural populations of I. capensis to measure the frequency of different density environments across space and time. We combined our empirical estimates of across‐environment genetic variance–covariance matrices and frequency of selective environments with hypothetical (yet realistic) selection gradients to project evolutionary responses in multiple density environments. Selection in common environments can lead to correlated responses to selection in rare environments that oppose and counteract direct selection in those rare environments. Our results highlight the importance of considering both the frequency of selective environments and the across‐environment genetic covariances in traits simultaneously. 相似文献
15.
Amra Noa Hui-Shun Kuan Vera Aschmann Vasily Zaburdaev Lennart Hilbert 《PLoS computational biology》2021,17(5)
The genome is packed into the cell nucleus in the form of chromatin. Biochemical approaches have revealed that chromatin is packed within domains, which group into larger domains, and so forth. Such hierarchical packing is equally visible in super-resolution microscopy images of large-scale chromatin organization. While previous work has suggested that chromatin is partitioned into distinct domains via microphase separation, it is unclear how these domains organize into this hierarchical packing. A particular challenge is to find an image analysis approach that fully incorporates such hierarchical packing, so that hypothetical governing mechanisms of euchromatin packing can be compared against the results of such an analysis. Here, we obtain 3D STED super-resolution images from pluripotent zebrafish embryos labeled with improved DNA fluorescence stains, and demonstrate how the hierarchical packing of euchromatin in these images can be described as multiplicative cascades. Multiplicative cascades are an established theoretical concept to describe the placement of ever-smaller structures within bigger structures. Importantly, these cascades can generate artificial image data by applying a single rule again and again, and can be fully specified using only four parameters. Here, we show how the typical patterns of euchromatin organization are reflected in the values of these four parameters. Specifically, we can pinpoint the values required to mimic a microphase-separated state of euchromatin. We suggest that the concept of multiplicative cascades can also be applied to images of other types of chromatin. Here, cascade parameters could serve as test quantities to assess whether microphase separation or other theoretical models accurately reproduce the hierarchical packing of chromatin. 相似文献
16.
Novel variation associated with species range expansion 总被引:1,自引:0,他引:1
When species shift their ranges to track climate change, they are almost certain to experience novel environments to which
they are poorly adapted. Otaki and co-workers document an explosion of wing pattern variation accompanying range expansion
in the pale grass blue butterfly. This pattern can be replicated in the laboratory using artificial selection on cold shocked
pupae, at temperature extremes typical of recently colonized environments. We discuss how this phenotypic plasticity may be
associated with successful colonization and how significant local adaptation is likely to re-establish developmental control.
Integrating knowledge of trait plasticity into current genetic models of adaptation is central to our understanding of when
and where a colonising population will be able to persist and adapt in novel surroundings. 相似文献
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18.
J. Crossa M. Vargas F. A. van Eeuwijk C. Jiang G. O. Edmeades D. Hoisington 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1999,99(3-4):611-625
An understanding of the genetic and environmental basis of genotype×environment interaction (GEI) is of fundamental importance
in plant breeding. In mapping quantitative trait loci (QTLs), suitable genetic populations are grown in different environments
causing QTLs×environment interaction (QEI). The main objective of the present study is to show how Partial Least Squares (PLS)
regression and Factorial Regression (FR) models using genetic markers and environmental covariables can be used for studying
QEI related to GEI. Biomass data were analyzed from a multi-environment trial consisting of 161 lines from a F3:4 maize segregating population originally created with the purpose of mapping QTLs loci and investigating adaptation differences
between highland and lowland tropical maize. PLS and FR methods detected 30 genetic markers (out of 86) that explained a sizeable
proportion of the interaction of maize lines over four contrasting environments involving two low-altitude sites, one intermediate-altitude
site, and one high-altitude site for biomass production. Based on a previous study, most of the 30 markers were associated
with QTLs for biomass and exhibited significant QEI. It was found that marker loci in lines with positive GEI for the highland
environments contained more highland alleles, whereas marker loci in lines with positive GEI for intermediate and lowland
environments contained more lowland alleles. In addition, PLS and FR models identified maximum temperature as the most-important
environmental covariable for GEI. Using a stepwise variable selection procedure, a FR model was constructed for GEI and QEI
that exclusively included cross products between genetic markers and environmental covariables. Higher maximum temperature
in low- and intermediate-altitude sites affected the expression of some QTLs, while minimum temperature affected the expression
of other QTLs.
Received: 10 January 1999 / Accepted: 12 March 1999 相似文献
19.
Growing evidence suggests that temporally fluctuating environments are important in maintaining variation both within and between species. To date, however, studies of genetic variation within a population have been largely conducted by evolutionary biologists (particularly population geneticists), while population and community ecologists have concentrated more on diversity at the species level. Despite considerable conceptual overlap, the commonalities and differences of these two alternative paradigms have yet to come under close scrutiny. Here, we review theoretical and empirical studies in population genetics and community ecology focusing on the ‘temporal storage effect’ and synthesise theories of diversity maintenance across different levels of biological organisation. Drawing on Chesson's coexistence theory, we explain how temporally fluctuating environments promote the maintenance of genetic variation and species diversity. We propose a further synthesis of the two disciplines by comparing models employing traditional frequency-dependent dynamics and those adopting density-dependent dynamics. We then address how temporal fluctuations promote genetic and species diversity simultaneously via rapid evolution and eco-evolutionary dynamics. Comparing and synthesising ecological and evolutionary approaches will accelerate our understanding of diversity maintenance in nature. 相似文献
20.
Accelerating the domestication of trees using genomic selection: accuracy of prediction models across ages and environments 总被引:2,自引:0,他引:2
Resende MF Muñoz P Acosta JJ Peter GF Davis JM Grattapaglia D Resende MD Kirst M 《The New phytologist》2012,193(3):617-624
? Genomic selection is increasingly considered vital to accelerate genetic improvement. However, it is unknown how accurate genomic selection prediction models remain when used across environments and ages. This knowledge is critical for breeders to apply this strategy in genetic improvement. ? Here, we evaluated the utility of genomic selection in a Pinus taeda population of c. 800 individuals clonally replicated and grown on four sites, and genotyped for 4825 single-nucleotide polymorphism (SNP) markers. Prediction models were estimated for diameter and height at multiple ages using genomic random regression best linear unbiased predictor (BLUP). ? Accuracies of prediction models ranged from 0.65 to 0.75 for diameter, and 0.63 to 0.74 for height. The selection efficiency per unit time was estimated as 53-112% higher using genomic selection compared with phenotypic selection, assuming a reduction of 50% in the breeding cycle. Accuracies remained high across environments as long as they were used within the same breeding zone. However, models generated at early ages did not perform well to predict phenotypes at age 6 yr. ? These results demonstrate the feasibility and remarkable gain that can be achieved by incorporating genomic selection in breeding programs, as long as models are used at the relevant selection age and within the breeding zone in which they were estimated. 相似文献