共查询到20条相似文献,搜索用时 0 毫秒
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Avais M. Daulat Mnica Silveira Wagner Alexandra Walton Emilie Baudelet Stphane Audebert Luc Camoin Jean‐Paul Borg 《Proteomics》2019,19(21-22)
SCRIB is a scaffold protein containing leucine‐rich repeats (LRR) and PSD‐95/Dlg‐A/ZO‐1 domains (PDZ) that localizes at the basolateral membranes of polarized epithelial cells. Deregulation of its expression or localization leads to epithelial defects and tumorigenesis in part as a consequence of its repressive role on several signaling pathways including AKT, ERK, and HIPPO. In the present work, a proteomic approach is used to characterize the protein complexes associated to SCRIB and its paralogue LANO. Common and specific sets of proteins associated to SCRIB and LANO by MS are identified and an extensive landscape of their associated networks and the first comparative analysis of their respective interactomes are provided. Under proteasome inhibition, it is further found that SCRIB is associated to the β‐catenin destruction complex that is central in Wnt/β‐catenin signaling, a conserved pathway regulating embryonic development and cancer progression. It is shown that the SCRIB/β‐catenin interaction is potentiated upon Wnt3a stimulation and that SCRIB plays a repressing role on Wnt signaling. The data thus provide evidence for the importance of SCRIB in the regulation of the Wnt/β‐catenin pathway. 相似文献
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IRS1/β‐Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells 下载免费PDF全文
Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves João Agostinho Machado‐Neto Renata Scopim‐Ribeiro Bruna Alves Fenerich Fernanda Borges da Silva Belinda Pinto Simões Eduardo Magalhães Rego Fabiola Traina 《Journal of cellular biochemistry》2017,118(7):1774-1781
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Progeny From Irradiated Colorectal Cancer Cells Acquire an EMT‐Like Phenotype and Activate Wnt/β‐Catenin Pathway 下载免费PDF全文
Lilian Gonçalves dos Reis Bastos Priscila Guimarães de Marcondes Julio Cesar Madureira de‐Freitas‐Junior Fernanda Leve André Luiz Mencalha Waldemir Fernandes de Souza Wallace Martins de Araujo Marcelo Neves Tanaka Eliana Saul Furquim Werneck Abdelhay José Andrés Morgado‐Díaz 《Journal of cellular biochemistry》2014,115(12):2175-2187
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Alternative RUNX1 Promoter Regulation by Wnt/β‐Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors 下载免费PDF全文
Matías A. Medina Giorgia D. Ugarte Macarena F. Vargas Miguel E. Avila David Necuñir Alvaro A. Elorza Soraya E. Gutiérrez Giancarlo V. De Ferrari 《Journal of cellular physiology》2016,231(7):1460-1467
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Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress 下载免费PDF全文
Afsane Bahrami Forouzan Amerizadeh Soodabeh ShahidSales Majid Khazaei Majid Ghayour‐Mobarhan Hamid Reza Sadeghnia Mina Maftouh Seyed Mahdi Hassanian Amir Avan 《Journal of cellular biochemistry》2017,118(8):1979-1983
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Wei Huang Shengyang Jin Wenbo Yang Shuo Tian Chunqing Meng Huan Deng Hong Wang 《Journal of cellular and molecular medicine》2020,24(3):2169-2177
A water‐soluble polysaccharide (APP‐AW) was isolated from Agrimonia pilosa and prepared to three sulphated derivatives (S1, S2 and S3). The results showed that pre‐treatment with APP‐AW, S1, S2 and S3 each at the concentration of 50 μg/mL for 48 hours was able to prevent cytotoxicity induced by 1 μmol/L dexamethasone (Dex) in MC3T3‐E1 cells via inhibition of apoptosis, which is in line with the findings in flow cytometry analysis. Meanwhile, the decreased ALP activity, collagen content, mineralization, BMP2, Runx2, OSX and OCN protein expression in DEX‐treated MC3T3‐E1 cells were reversed by the addition of APP‐AW, S1, S2 and S3. Moreover, APP‐AW, S1, S2 and S3 rescued DEX‐induced increase of Bax, cytochrome c and caspase‐3 and decrease of Bcl‐2, Wnt3, β‐catenin and c‐Myc protein expression in MC3T3‐E1 cells. Our findings suggest that pre‐treatment with APP‐AW, S1, S2 and S3 could significantly protect MC3T3‐E1 cells against Dex‐induced cell injury via inhibiting apoptosis and activating Wnt/β‐Catenin signalling pathway, thus application of these polysaccharides may be a promising alternative strategy for steroid‐induced avascular necrosis of the femoral head (SANFH) therapy. 相似文献
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Wnt/β‐Catenin Signaling Activates Expression of the Bone‐Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types 下载免费PDF全文
Oscar A. Vega Claudia M.J. Lucero Hector F. Araya Sofia Jerez Julio C. Tapia Marcelo Antonelli Flavio Salazar‐Onfray Facundo Las Heras Roman Thaler Scott M. Riester Gary S. Stein Andre J. van Wijnen Mario A. Galindo 《Journal of cellular biochemistry》2017,118(11):3662-3674