Stratigraphical distribution of the Ordovician graptolite Azygograptus Nicholson & Lapworth in the Central Andean Basin (northwestern Argentina and southern Bolivia)

We analyzed new occurrences of Azygograptus lapworthi from the Cordillera Oriental, Argentina. The bearer sandstones levels, corresponding to the Acoite Formation, are overlying the deposits, in which the Didymograptellus bifidus Biozone (Lower Ordovician, upper Floian, Fl3) was previously recognized, and are overlain by younger pelitic levels yielding Xiphograptus lofuensis (Middle Ordovician, early Dapingian, Dp2). Previous records from the Central Andean Basin are also reviewed in detail and accurately correlated, allowing us to conclude that the Azygograptus lapworthi Biozone corresponds to the Middle Ordovician (lower Dapingian, Dp1). This biostratigraphic framework documents that the transition between the Lower and Middle Ordovician deposits occurs in the uppermost levels of the Acoite Formation in the Argentine Cordillera Oriental. It is additionally integrated with up to date conodont records to establish a high-resolution regional correlation, with equivalent deposits from the Puna of northwestern Argentina and Cordillera Oriental of Bolivia, and to discuss new insights for global correlation.     

The earliest known estuarine bivalve assemblage, Lower Ordovician of northwestern Argentina

The oldest known estuarine bivalve assemblage is documented from the Lower Ordovician (upper Arenig-lower Llanvirn) Alto del Cóndor Formation, which crops out in the Cordillera Oriental of northwestern Argentina. This unit displays most of the diagnostic sedimentary attributes of estuarine environments. Biotic components include low-diversity trace fossils and a peculiar bivalve fauna consisting of the new genera Konduria, Pseudoredonia, and Pucamya, and the new species Redonia condorensis. This constitutes the earliest known occurrence of bivalves in brackish waters, suggesting that the capability of this clade to colonize estuarine environments developed early in their radiation.     

New discoveries of vertebrates from a near-shore marine fauna from the Early Miocene of northwestern Venezuela

New discoveries from a recently described nearshore marine fauna from northwestern Venezuela of presumed early Miocene age are reported. The fossils consist of a cranial portion of a crocodile assigned to the Tbmistominae, confirming the presence of this group in South America, and the scapula of a cetacean with affinities to the Platanistoidea. The stratigraphic section of the fossil locality ‘Cerro La Cruz’ consists of ca. 87 m of clayey marls interbedded with thin hardground units, with the upper strata being gypsiferous. The fossils were found in sandstones stratigraphically above this sequence.      

The graptolite correlation of the North American Upper Ordovician Standard

The North American Upper Ordovician reference standard, the Cincinnatian Series, contains rich shelly microfossil faunas in its type area in the Cincinnati Region but graptolites are uncommon in most of its shallow-water calcareous sediments. Consequently, the graptolite correlation of this key sequence has remained uncertain, in part, even controversial. A review of both previously published recently discovered graptolite Occurrences in the type Cincinnatian, combined with data from the important graptolite successions in Oklahoma New York-Quebec, has not only clarified the graptolite correlation of the Cincinnatian but also added new data on the morphology taxonomy, the vertical horizontal distribution, of several taxa. The information now at hand indicates that the Edenian Stage correlates with the C. spiniferus Zone, the Maysvillian Stage with the C. pygmaeus lower middle P. manitoulinensis Zone, the Richmondian Stage with the upper P. manitoulinensis , the D. complanatus , possibly part of the C. inuiti Zone. Comparison between graptolite conodont biostratigraphic evidence reveals no apparent conflict. Correlations are proposed between Upper Ordovician North American stages, graptolite conodont zones, successions in Texas, Oklahoma, Sweden, European graptolite zones, British series.     

New macrostomatan snake from the Paleogene of northwestern Argentina

The lower Eocene Lumbrera Formation in Salta province, northwestern Argentina, outstands for providing snake remains from a non-Patagonian Paleogene site. The material consists of articulated precloacal vertebrae that represent a new medium-sized macrostomatan snake, namely Amaru scagliai nov. gen., nov. sp. The vertebral characters of Amaru scagliai nov. gen., nov. sp., suggest affinities with advanced clades, which is consistent with the recognition of derived macrostomatans in the early Paleocene of Bolivia and early Eocene of Brazil. The new snake confirms the presence of macrostomatan snakes in South America as early as the Eocene and suggests that the southern continents may have played an unsuspected role in the origin and evolution of advanced macrostomatans during the earliest Cenozoic.     

Revision of the Zone 13 graptolite biostratigraphy in the Marathon, Texas, standard succession and its bearing on Upper Ordovician graptolite biogeography

One of the long-standing problems in North American graptolite biostratigraphy is the distinct differences in assemblages of post-Climacograptus bicornis age between the classical graptolite sequences in the New York - Quebec and Marathon, west Texas, regions. These have been attributed either to faunal provincialism or to the presence of a major hiatus between the Woods Hollow and Maravillas formations in Texas. New collections from the key Marathon Picnic Grounds section contain diagnostic Late Ordovician graptolites that confirm the existence of a major stratigraphic gap below the Maravillas Formation. The lower Maravillas Formation (Zone 13) has a Late Ordovician, low-diversity Pacific Province graptolite fauna that includes the biostratigraphically diagnostic species Climacograptus nevadensis, C. tubuliferus, Orthograptus fastigatus and Dicellograptus ornatus. Zone 13 graptolite assemblages from the Marathon region correlate with the C. tubuliferus to D. ornatus zones in the Trail Creek, Idaho, succession, the Ea4-Bo2 interval in Victoria, the O. fastigatus Zone in the Canadian Arctic Islands, the O. quadrimucronatus to D. ornatus zones of the Canadian Cordillera, and the D. complanatus to D. anceps zones in Scotland. The hiatus between the Woods Hollow and Maravillas formations spans an interval corresponding to at least the Eal Ea3 interval in Australia, the C. americanus to upper A. manitoulinensis zones in the New York - Quebec succession, and the D. clingani and P. linearis zones in Scotland. These results agree with the magnitude of the hiatus previously indicated by conodont biostratigraphy. Late Ordovician graptolite distribution patterns in North America can be explained by an extension of Cooper, Fortey & Lindholm's (1991; Lethaia 24) Lower Ordovician graptolite biofacies model into the Upper Ordovician, which incorporates both lateral water-mass specificity and depth stratification. Using this model, we recognize in Laurentia two separate biofacies among tropical-zone Late Ordovician Pacific Province graptolite faunas, a cosmopolitan Oceanic biofacies, and a cratonic Laurentian biofacies. The lower Maravillas Formation graptolite fauna is clearly part of the Oceanic biofacies, whereas the coeval Appalachian faunas represent the Laurentian biofacies. □Graptolites, Ordovician, biostratigraphy, Texas, biofacies, biogeography.     

New insights into the epigenetics of osteoporosis

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in the bone marrow compartment. The decrease in bone mass results from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The deficiency of bone cells to replace the resorpted bone can be due to a preferential differentiation of bone marrow stromal cells into adipocytes at the expense of osteoblasts. Consequently, the processes that control the differentiation of osteoclasts, osteoblasts and adipocytes play a crucial role in bone metabolism. It is known that epigenetic mechanisms are critical regulator of the differentiation programs for cell fate and moreover are subject to changes during aging. Here, we summarize recent findings on the role of epigenetics in the modulation of mechanisms that may be associated with osteoporosis. In particular, we focus on disturbances in the bone remodeling process described in human studies that address the epigenetic regulation of the osteoblast/adipocyte balance.     

New insights into the biology of preeclampsia

Despite recent research progress, the biology of preeclampsia is still poorly understood and neither effective prediction nor causal therapy have yet emerged. Nevertheless, recent studies have documented new and exciting pathophysiological mechanisms for the origin and development of preeclampsia. These studies provide a more differentiated view on alterations of particular peptide systems with strong impact on angiogenesis and cardiovascular regulation in this pregnancy disorder. With the identification of the antiangiogenic factor soluble fms-like tyrosine kinase 1 and the agonistic autoantibody to the angiotensin II type 1 receptor, two factors have been described with a clear linkage to the development of the disease. This review focuses on the most recent and relevant insights into the biology of preeclampsia and develops hypotheses regarding possible links between the reported aspects of preeclampsia.     

New insights into cell signaling

Cell signaling has been well recognized as a highly complex process, which mainly delivers environmental information into ceils. A number of regutating mechanisms of cell signaling have been uncovered in great details. Recently,IMCB also published several articles on new members or regulating mechanisms of various cell signaling pathways （Wu, 2013）. In this issue, the collection of four articles will add new aspects to understanding the molecular mechanisms of cell signaling.     

New insights into motor cortex

An exciting new experiment on the motor cortex of monkeys, by Shenoy and colleagues, begins to elucidate how the neuronal ensemble travels in a systematic fashion through state space. This trajectory through state space may help to explain how the motor cortex sets up and then triggers arm movements.     

New insights into Drosophila vision

Studies of the Drosophila visual system have provided valuable insights into the function and regulation of phototransduction signaling pathways. Much of this work has stemmed from or relied upon the genetic tools offered by the Drosophila system. In this issue of Neuron, Wang and colleagues and Acharya and colleagues have further exploited the Drosophila genetic system to characterize two new phototransduction players.     

New insights into craniofacial morphogenesis

No region of our anatomy more powerfully conveys our emotions nor elicits more profound reactions when disease or genetic disorders disfigure it than the face. Recent progress has been made towards defining the tissue interactions and molecular mechanisms that control craniofacial morphogenesis. Some insights have come from genetic manipulations and others from tissue recombinations and biochemical approaches, which have revealed the molecular underpinnings of facial morphogenesis. Changes in craniofacial architecture also lie at the heart of evolutionary adaptation, as new studies in fish and fowl attest. Together, these findings reveal much about molecular and tissue interactions behind craniofacial development.