共查询到20条相似文献,搜索用时 31 毫秒
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G Grigoriadis Y Zhan R J Grumont D Metcalf E Handman C Cheers S Gerondakis 《The EMBO journal》1996,15(24):7099-7107
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Wang KY Arima N Higuchi S Shimajiri S Tanimoto A Murata Y Hamada T Sasaguri Y 《FEBS letters》2000,473(3):345-348
It is known that histamine suppresses gene expression and synthesis of tumor necrosis factor alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in human peripheral blood mononuclear monocytes (HPM) or alveolar macrophages via histamine H2 receptors. We investigated the effect of histamine and differentiation in macrophages on the expression and secretion of TNF-alpha, TNF-alpha-converting enzyme (TACE), and histamine H1 and H2 receptors by use of a leukemia cell line, U937, and HPM. Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. Therefore, histamine failed to inhibit up-regulated expression of TNF-alpha induced by LPS in macrophages. The switch from H2 to H1 receptors during differentiation in the monocyte/macrophage lineage could participate in the pathogenic processes of atherosclerosis and inflammatory reactions in the arterial wall. 相似文献
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Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage 总被引:3,自引:0,他引:3
Carleton M Haks MC Smeele SA Jones A Belkowski SM Berger MA Linsley P Kruisbeek AM Wiest DL 《Journal of immunology (Baltimore, Md. : 1950)》2002,168(4):1649-1658
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