共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
Allan C. Halpern 《Pigment cell & melanoma research》2013,26(1):5-8
Vitamin D has been the focus of considerable recent scientific study and media attention because of a growing appreciation of its potential importance in extra‐skeletal health. This ‘Perspective’ presents data supporting the viewpoint that physicians should not routinely test vitamin D levels in the general population but should routinely endorse vitamin D supplementation at levels recommended by the Institute of Medicine. It further reasons that it is unadvisable to recommend intentional limited sun exposure as a source of vitamin D. 相似文献
3.
Irwin PJ 《International journal for parasitology》2002,32(5):581-593
In recent years there have been many changes to the ways that clinical veterinary science is conducted and nowhere is this more evident than in companion animal practice. Veterinarians working with pet dogs and cats are facing new challenges associated with the emergence and re-emergence of parasitic diseases. Some, such as Neospora caninum, have been recently recognised; others like Giardia and Cryptosporidium have been reported with increasing frequency, in part as a result of laboratory tests with improved sensitivity and specificity. In many regions, the emergence of parasitic diseases has been a consequence of pet travel and exotic diseases pose a unique diagnostic challenge for the veterinarian, as the index of suspicion for these conditions may be absent. The ranges of certain vector-borne diseases such as babesiosis, hepatozoonosis, ehrlichiosis, leishmaniasis and dirofilariasis are extending due to ecological and climatic changes and enhanced by animals with subclinical infection returning home from endemic areas. In companion animal practice, veterinarians have the additional responsibility of providing accurate information about the zoonotic transmission of parasite infections from pets, especially to those most vulnerable such as children, the elderly and the immunocompromised. Effective education is vital to allay public concerns and promote responsible pet ownership. 相似文献
4.
Giovanna Pirri Andrea Giuliani Silvia Fabiole Nicoletto Lorena Pizzuto Andrea C. Rinaldi 《Central European Journal of Biology》2009,4(3):258-273
Lipopeptide antibiotics represent an old class of antibiotics that were discovered over 50 years ago, which includes the old
polymyxins but also new entries, such as the recently approved daptomycin. They generally consist of a hydrophilic cyclic
peptide portion attached to a fatty acid chain which facilitates insertion into the lipid bilayer of bacterial membranes.
This review presents an overview of this class of antibiotics, focusing on their therapeutic applications and putting particular
emphasis on chemical modifications introduced to improve their activity. 相似文献
5.
6.
Kellermayer R 《Cell calcium》2008,43(2):105-106
7.
8.
G W Duff 《The Yale journal of biology and medicine》1986,59(2):125-130
Fever is a phylogenetically ancient host response to infection, being found in fish and lizards, and conserved, with all its metabolic costs, in the higher mammals, including man. The conservation of the fever response in evolution is used as an argument for its survival value and, indeed, in experiments with cold-blooded animals "behavioral fever" has been demonstrated to reduce mortality associated with infection. Recent advances in the biology of interleukin-1 and other cytokines have allowed the testing, in vitro, of components of mammalian host defense (such as immune cell function) at temperatures typical of fever, and marked effects have been found. It remains to be demonstrated, however, that the hyperthermia of fever has survival value in man, and though it might be predicted that fever would be beneficial in infections, it is quite possible that in some circumstances even mild fever could be construed as harmful. In autoimmunity, for example, increased T-cell activation at febrile temperatures may well accelerate disease progress. 相似文献
9.
10.
11.
12.
13.
This review deals with clinical applications of compounds that inhibit the action of the protease encoded within the genome of human immunodeficiency virus (HIV). The HIV-protease is essential for viral maturation and represents an important therapeutic target in the fight against AIDS. Following a brief overview of the enzyme structure and function, the article focuses on a number of peptide and non-peptide based HIV-protease inhibitors that are in current clinical use. These drugs are discussed both with respect to their efficacy in treatment of AIDS, and to problems related to insurgence of viral resistance and side effects seen to date in patient populations. 相似文献
14.
Dreyer G Norões J Figueredo-Silva J Piessens WF 《Parasitology today (Personal ed.)》2000,16(12):544-548
The pathogenesis of lymphatic filariasis has been a matter of debate for many decades. Here, Gerusa Dreyer and colleagues propose a dynamic model of bancroftian filariasis, integrating clinical, parasitological, surgical, therapeutic, ultrasonographic and histopathological data. This model has profound implications for filariasis control programs and the management of the individual patient. 相似文献
15.
Rose K 《Birth defects research. Part B, Developmental and reproductive toxicology》2011,92(4):252-253
With the emphasis of US American and European legislators on consideration of children in the drug development process regulatory authorities ask increasingly for additional non-clinical data to elucidate the safety of a given drug in development in future pediatric use. Juvenile animal studies are increasingly requested. These requests should never be tick box requests. Companies, academic toxicologists, clinicians, and regulatory authorities need a dialogue to differentiate between the perceived need to do "something" and the request for studies that have clinically meaningful results. 相似文献
16.
17.
Taïeb A 《Pigment cell & melanoma research》2012,25(1):9-13
From a therapeutic standpoint, vitiligo is still regarded by many physicians as a simple problem of regenerative medicine, with the main aim to repopulate the depigmented skin with functional melanocytes from the margins of the lesions or from intact progenitors in hair follicles. However, recent research in vitiligo suggests that various local triggers alert the skin immune innate system and may precede adaptive immune responses targeting melanocytes. This scenario is close to that of other common skin inflammatory disorders like psoriasis and atopic, and suggests to target as a priority this clinically silent inflammatory component of he disease. This perspective highlights possible targets for intervention. 相似文献
18.
19.
Mariah B Pate John Kelly Smith David S Chi Guha Krishnaswamy 《Clinical and molecular allergy : CMA》2010,8(1):1-13