"Blood and guts": one component of an integrated program in biologic sciences as applied to medicine.

The 3-year medical school program at McMaster University encourages an approach to learning a physician can apply throughout his or her career. The program has four phases and provides early exposure to relevant clinical material. In phase 3, the basic science phase, the structure and function of organ systems in health and disease are studied. Understanding the mechanisms of disease in order to be able to relate clinical symptoms and signs to physiologic and pathologic processes is emphasized. The four 10-week units deal with groups of organ systems. The "blood and guts" unit teaches the student hematology and gastroenterology through a variety of problem-based methods. Specialists in the relevant scientific disciplines influence selection and construction of the problems presented. The students are evaluated by the faculty tutor on their accomplishment of specific objectives related to their competence in solving biomedical problems.     

Brazilian Racial Terms: Some Aspects of Meaning and Learning

Harris notes that the New Ethnography has been characterized by a lack of quantitative methods. In a study of racial vocabulary in a Brazilian village, quantitative procedures are employed to show that, despite considerable ambiquity, a small portion of the corpus of 116 terms forms the cognitive map of most informants and organizes the bulk of the domain. Data on how children acquire the vocabulary is used to demonstrate that skin color and hair form are the primary variables .     

Biological transcomplementary activation as a novel and effective strategy applied to the generation of porcine somatic cell cloned embryos

A novel method termed the biological transcomplementary activation (B-TCA) has been recently utilized for the stimulation of porcine oocytes reconstituted by somatic cell nuclear transfer (SCNT). The use of cytosolic components originating from fertilized (FE) rabbit zygotes as the stimuli for the B-TCA of SCNT-derived pig oocytes appeared to be a highly efficient strategy applied to promote the in vitro development of cloned embryos, leading to a significant improvement in the blastocyst yield (43.6%) compared to the yields achieved using the standard protocol of simultaneous fusion and electrical activation (SF-EA; [31.3%]) or the protocol of delayed electrical activation (D-EA) independent of extracellular Ca²⁺ ions (0%). The FE rabbit zygote cytoplast-mediated B-TCA resulted in the increased blastocyst formation rate of porcine cloned embryos as compared to the B-TCA triggered by either cytoplasts isolated from pig parthenogenotes (PAs; [27.8%]) or rabbit PA-descended cytoplasts (0%). A considerably lower percentage of blastocysts containing apoptotic and/or necrotic (annexin V-eGFP-positive) cells were obtained from the SCNT-derived oocytes stimulated by the FE rabbit zygote cytoplast-based B-TCA (22.2%) compared to those stimulated using the SF-EA protocol (35.1%). In contrast to the B-TCA induced by FE rabbit zygote cytoplasts, apoptosis/necrosis incidence decreased totally among the cloned pig blastocysts that developed from reconstituted oocytes undergoing the porcine PA cytoplast-evoked B-TCA. In conclusion, the FE rabbit zygote cytoplast-mediated B-TCA turned out to be a relatively effective strategy for the in vitro production of porcine blastocyst clones of higher quality compared to those created using the standard SF-EA approach.     

The paper chromatography as applied to histological sections

Summary The results of tissue section chromatography are given in comparison with histochemical section tests.Qualitative research concerns essential components of organism — amino acids, carbohydrates, lipids, and some steroids. Suggestions referring to quantitative prospects of the section chromatography method are given.With 6 Figures in the Text     

我国生物制品通用名命名原则的修订

对我国生物制品通用名命名原则进行了立题研究,旨在建立和完善我国生物制品通用名称命名原则。通过分析我国生物制品通用名现状、存在的问题及新型生物药发展趋势,研究比较了国际上具有主导性的药品通用名命名体系,并参照世界卫生组织国际非专利名称(WHO INN)命名原则,在中文语言识别的基础上,对我国生物制品通用名称命名原则提出了具体的增修订意见。