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The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle 总被引:2,自引:0,他引:2
Ewen EP Snyder CM Wilson M Desjardins D Naya FJ 《The Journal of biological chemistry》2011,286(34):29644-29653
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Raghunath Chatterjee Charles Vinson 《Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms》2012,1819(7):763-770
CG methylation is an epigenetically inherited chemical modification of DNA found in plants and animals. In mammals it is essential for accurate regulation of gene expression and normal development. Mammalian genomes are depleted for the CG dinucleotide, a result of the chemical deamination of methyl-cytosine in CG resulting in TpG. Most CG dinucleotides are methylated, but ~ 15% are unmethylated. Five percent of CGs cluster into ~ 20,000 regions termed CG islands (CGI) which are generally unmethylated. About half of CGIs are associated with housekeeping genes. In contrast, the gene body, repeats and transposable elements in which CGs are generally methylated. Unraveling the epigenetic machinery operating in normal cells is important for understanding the epigenetic aberrations that are involved in human diseases including cancer. With the advent of high-throughput sequencing technologies, it is possible to identify the CG methylation status of all 30 million unique CGs in the human genome, and monitor differences in distinct cell types during differentiation and development. Here we summarize the present understanding of DNA methylation in normal cells and discuss recent observations that CG methylation can have an effect on tissue specific gene expression. We also discuss how aberrant CG methylation can lead to cancer. This article is part of a Special Issue entitled: Chromatin in time and space. 相似文献
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Scherrer K 《Biochimie》2012,94(4):1057-1068
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G. Chinetti-Gbaguidi B. Staels 《Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids》2009,1791(6):486-493
Macrophages play a pivotal role in the development of atherosclerosis. After recruitment in the sub-endothelial space, monocytes differentiate into macrophages, accumulate lipids thus forming foam cells and secrete pro-inflammatory and matrix-degrading factors, thus playing a role in plaque development, inflammation and instability. Therefore, pharmacological modulation of macrophage functions represents an attractive strategy for the prevention and treatment of cardiovascular diseases caused by atherosclerosis. 相似文献
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