Dragging scientific publishing into the 21st century

Scientific publishers must shake off three centuries of publishing on paper and embrace 21st century technology to make scientific communication more intelligible, reproducible, engaging and rapidly available.The Internet has massively disrupted how we communicate - primarily for the better. Many business sectors, however, have struggled to adapt to online platforms, with many simply resisting change. The newspaper industry is an example of a centuries-old industry persisting in the face of new conditions - until it can’t. In the early 1990s the Web began displacing traditional information delivery. By the mid 2000s it had become a widespread facet of life in many countries. Web 1.0 journalism translated ink to pixels, but as technology advanced the slow erosion of print became a landslide [1].Scientific publishing is following a similar path, with its hesitance to adapt and slow (or no) adoption of the many advantages the Internet affords.For now, scientific publishing remains profitable. Nevertheless, its sustainability rests upon antiquated pillars. Scholarly print journals date back hundreds of years to the availability of a cheap distribution method with the introduction of the printing press.Most journals have made only incremental changes. A few have taken some advantage of the Internet and experimented with multimedia, but use of the medium has been limited primarily to extra content, such as unsearchable encyclopedic online supplements to accompany articles that maintain print page limits; or publishing many more articles by relaxing peer-review requirements for ‘novelty’, as exemplified by PLoS ONE, which has published 30,000 articles in 2013 alone [2]. Overall print-era anachronisms still persist through the continuation of page limits and surcharges and the release of discrete issues, as if all articles remain subject to print-only production schedules.So how do we imagine the future of scientific publishing?     

Environmental refugees: a growing phenomenon of the 21st century

There is a new phenomenon in the global arena: environmental refugees. These are people who can no longer gain a secure livelihood in their homelands because of drought, soil erosion, desertification, deforestation and other environmental problems, together with the associated problems of population pressures and profound poverty. In their desperation, these people feel they have no alternative but to seek sanctuary elsewhere, however hazardous the attempt. Not all of them have fled their countries, many being internally displaced. But all have abandoned their homelands on a semi-permanent if not permanent basis, with little hope of a foreseeable return. In 1995, environmental refugees totalled at least 25 million people, compared with 27 million traditional refugees (people fleeing political oppression, religious persecution and ethnic troubles). The total number of environmental refugees could well double by the year 2010, and increase steadily for a good while thereafter as growing numbers of impoverished people press ever harder on overloaded environments. When global warming takes hold, there could be as many as 200 million people overtaken by sea-level rise and coastal flooding, by disruptions of monsoon systems and other rainfall regimes, and by droughts of unprecedented severity and duration.     

Biotechnology in the 21st century

Although the future is unpredictable, it is highly likely that biotechnology will play a much more visible and significant role in the 21st century than it did in the 20th century. The number and kinds of drugs provided by biotechnology will expand markedly and biotechnology will stand at the center of the oncoming revolution in bioinformatics.     

Maize selection passes the century mark: a unique resource for 21st century genomics

The Illinois Long-Term Selection Experiment for grain protein and oil concentration in maize (Zea mays) is the longest continuous genetics experiment in higher plants. A total of 103 cycles of selection have produced nine related populations that exhibit phenotypic extremes for grain composition and a host of correlated traits. The use of functional genomics tools in this unique genetic resource provides exciting opportunities not only to discover the genes that contribute to phenotypic differences but also to investigate issues such as the response of plant genomes to artificial selection, the genetic architecture of quantitative traits and the source of continued genetic variation within domesticated crop genomes.     

Crop improvement in the 21st century

Crop yields increased dramatically in the 20th century as recorded on Broadbalk or in world averages. The vast majority of that increase has occurred since the last world war and has been powered by changes in the genetic potential of the crop and in the way in which it has been managed. Nevertheless, the challenge to feed a world population that is likely to rise to 8 billion is formidable, particularly since recent analyses suggest that the rate of increase in yields of several crops may have dropped over the last decade. What are the opportunities to meet this challenge and to continue to improve the yields of our crops? Improvements in agronomy are likely to be more concerned with efficiency and elegance rather than in major breakthroughs. More sophisticated crop protection chemicals designed on the basis of vastly increased screening potentials and (at last?) possibilities of rational design will be supplemented by a battery of decision support systems to aid management choices which can be precisely implemented. Genetic improvement is the area in which to-look for the major breakthroughs. The broad potential of recombinant DNA technology will provide the possibility of both molecular analyses of crop productivity and ways in which it may be possible to improve that productivity. The goal of analysis may be approached in three ways: starting at the beginning by generating complete sequences of the plant genome; starting at the end by genetic analysis of phenotypes using genetic marker technology; or, starting in the middle, by metabolic analysis. Improvements may be obtained by re-assorting what has been achieved through enhanced breeding technologies, by randomly induced change, and by generation of totally new possibilities through biochemical engineering. Examples of all approaches will be given. The onset of genomics will provide massive amounts of information, but the success will depend on using that to improve crop phenotypes. The ability to meet the challenges of the 21st century will depend on the ability to close that 'phenotype gap'.     

Comparative endocrinology in the 21st century

Hormones coordinate developmental, physiological, and behavioral processes within and between all living organisms. They orchestrate and shape organogenesis from early in development, regulate the acquisition, assimilation, and utilization of nutrients to support growth and metabolism, control gamete production and sexual behavior, mediate organismal responses to environmental change, and allow for communication of information between organisms. Genes that code for hormones; the enzymes that synthesize, metabolize, and transport hormones; and hormone receptors are important targets for natural selection, and variation in their expression and function is a major driving force for the evolution of morphology and life history. Hormones coordinate physiology and behavior of populations of organisms, and thus play key roles in determining the structure of populations, communities, and ecosystems. The field of endocrinology is concerned with the study of hormones and their actions. This field is rooted in the comparative study of hormones in diverse species, which has provided the foundation for the modern fields of evolutionary, environmental, and biomedical endocrinology. Comparative endocrinologists work at the cutting edge of the life sciences. They identify new hormones, hormone receptors and mechanisms of hormone action applicable to diverse species, including humans; study the impact of habitat destruction, pollution, and climatic change on populations of organisms; establish novel model systems for studying hormones and their functions; and develop new genetic strains and husbandry practices for efficient production of animal protein. While the model system approach has dominated biomedical research in recent years, and has provided extraordinary insight into many basic cellular and molecular processes, this approach is limited to investigating a small minority of organisms. Animals exhibit tremendous diversity in form and function, life-history strategies, and responses to the environment. A major challenge for life scientists in the 21st century is to understand how a changing environment impacts all life on earth. A full understanding of the capabilities of organisms to respond to environmental variation, and the resilience of organisms challenged by environmental changes and extremes, is necessary for understanding the impact of pollution and climatic change on the viability of populations. Comparative endocrinologists have a key role to play in these efforts.     

Haldane's rule in the 21st century

Haldane's Rule (HR), which states that 'when in the offspring of two different animal races one sex is absent, rare, or sterile, that sex is the heterozygous (heterogametic) sex', is one of the most general patterns in speciation biology. We review the literature of the past 15 years and find that among the ～85 new studies, many consider taxa that traditionally have not been the focus for HR investigations. The new studies increased to nine, the number of 'phylogenetically independent' groups that comply with HR. They continue to support the dominance and faster-male theories as explanations for HR, although due to increased reliance on indirect data (from, for example, differential introgression of cytoplasmic versus chromosomal loci in natural hybrid zones) unambiguous novel results are rare. We further highlight how research on organisms with sex determination systems different from those traditionally considered may lead to more insight in the underlying causes of HR. In particular, haplodiploid organisms provide opportunities for testing specific predictions of the dominance and faster X chromosome theory, and we present new data that show that the faster-male component of HR is supported in hermaphrodites, suggesting that genes involved in male function may evolve faster than those expressed in the female function.     

Interdisciplinary sciences in the 21st century

With the advance of genome projects the search for the order of cellular processes has become a realistic goal. Yet this order is hidden behind a screen of data, which obscures the actual connectivity of genes and proteins. In order to expose the true nature of these networks it becomes necessary to apply in silico analysis based on certain parallels between biological and complex technical systems. These efforts far exceed current notions of computational biology.