共查询到20条相似文献,搜索用时 8 毫秒
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植物的环境信号分子茉莉酸及其生物学功能 总被引:3,自引:0,他引:3
茉莉酸信号分子参与植物生长发育众多生理过程的调控,尤其是作为环境信号分子能有效地介导植物对生物及非生物胁迫的防御反应。迄今已知具有信号分子生理功能的至少包括茉莉酸(jasmonic acid,JA)以及茉莉酸甲酯(methyl jasmonate,Me JA)和茉莉酸-异亮氨酸复合物(jasmonoyl-isoleucine,JA-Ile)等茉莉酸衍生物,统称为茉莉酸类化合物(jasmonates,JAs)。从环境信号分子角度介绍了茉莉酸信号的启动(环境信号感知与转导、茉莉酸类化合物合成)、传递(局部传递、维管束传输、空气传播)和生物学功能(茉莉酸信号受体、调控的转录因子、参与的生物学过程)。 相似文献
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《Journal of Physiology》1996,90(3-4):165-166
Heterosynaptic long-term depression (hetLTD) at one input can be induced by applying a conditioning stimulus to an adjacent set of synapses. In hippocampal CA1 pyramidal cells, our results suggest that hetLTD is triggered by an extracellular diffusible factor that is released following tetanic activation of NMDA receptors. This hetLTD occludes with homosynaptic LTD suggesting common underlying mechanisms. 相似文献
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Corticosteroid hormones are secreted from the adrenal glands in hourly pulses and signal the hippocampus for the development and function. In contrast, the stress-induced rise in corticosteroid concentrations has a profound effect on emotional arousal, motivational processes and cognitive performance. This rise is required as the stress response to maintain homeostasis in the living body or restore it. However, abnormal rise in corticosteroid concentrations is a disadvantage to the hippocampus. Corticosteroid-glutamatergic interactions during information processing are proposed as a potential model to explain many of the diverse actions of corticosteroids in synaptic plasticity such as long-term potentiation and cognition. Because zincergic neurons are a subtype of glutamatergic neurons and release Zn(2+) and glutamate into the synaptic cleft, it is possible that homeostasis of synaptic Zn(2+), in addition to homeostasis of glutamate, is modified by glucocorticoids, followed by the changes in cognitive function and stress response. Zn(2+) signal participates in cognitive and emotional behavior in cooperation with signaling of glucocorticoids and glutamate, while can disadvantageously act on the hippocampus under sever stress circumstances. This paper analyzes the actions of glucocorticoid-mediated Zn(2+) signal in the hippocampus under stressful circumstances and its significance in both hippocampal function and dysfunction. 相似文献
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Presynaptic specificity of endocannabinoid signaling in the hippocampus 总被引:19,自引:0,他引:19
Endocannabinoids are retrograde messengers released by neurons to modulate the strength of their synaptic inputs. Endocannabinoids are thought to mediate the suppression of GABA release that follows depolarization of a hippocampal CA1 pyramidal neuron-termed "depolarization-induced suppression of inhibition" (DSI). Here, we report that DSI is absent in mice which lack cannabinoid receptor-1 (CB1). Pharmacological and kinetic evidence suggests that CB1 activation inhibits presynaptic Ca2+ channels through direct G protein inhibition. Paired recordings show that endocannabinoids selectively inhibit a subclass of synapses distinguished by their fast kinetics and large unitary conductance. Furthermore, cannabinoid-sensitive inputs are unusual among central nervous system synapses in that they use N- but not P/Q-type Ca2+ channels for neurotransmitter release. These results indicate that endocannabinoids are highly selective, rapid modulators of hippocampal inhibition. 相似文献
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Sem'ianov AV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2004,54(1):68-84
Glutamate and GABA are major synaptic neurotransmitters in the hippocampus. However, their action is not confined to restricted postsynaptic area. A number of sources, such as reversed uptake, glial exocytosis, osmotically driven release, and neurotransmitter spillover can build up the extracellular concentration of these amino acids. GABA and glutamate receptors can be found at various glial and neuronal compartments. Subcellular distribution, subunit composition, and metabotropic/ionotropic nature of these receptors will determine an effect of their activation. This review surveys general principles for diffuse glutamate- and GABA-mediated extrasynaptic neurotransmission, interaction between synaptic and extrasynaptic signaling and between diffuse neurotransmitters themselves. 相似文献
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On the basis of the evidence of the transient learning impairment of young adult rats fed a zinc-deficient diet for 4 weeks, zinc concentration in the hippocampus was examined in the zinc-deficient rats to understand the mechanism of brain dysfunction in zinc deficiency. Zinc concentration in the hippocampus, as well as that in other brain regions, was not decreased by 4-week zinc deprivation. When Timm's stain, with which histochemically reactive zinc in the presynaptic vesicles is detected, was compared between the control and zinc-deficient rats, the intensity of Timm's stain in the hippocampus was almost the same between them. In the hippocampus, zinc concentration in the synaptosomal fraction was not also decreased by 4-week zinc deprivation, whereas that in the crude nuclear fraction was significantly increased. These results suggest that zinc concentration in the presynaptic vesicles is not decreased in young adults rats by 4-week zinc deprivation. It is likely that zinc-requiring systems in the nucleus are more responsive to zinc deficiency than vesicular zinc. This responsiveness appears to be involved in the transient learning impairment. 相似文献
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Ultrastructural features of skeletal muscle in mice after physical exercise: its relation to the pathogenesis of leucocyte invasion 总被引:1,自引:0,他引:1
H Michna 《Acta anatomica》1989,134(4):276-282
This study was designed to elucidate which factor(s) trigger off the enhanced macrophage activity after strenuous physical exercise. For an understanding of the cause of this phenomenon we extended the study of the ultrastructural features of skeletal muscle after physical exercise to its possible relation to the pathogenesis of leucocyte invasion. Ultrastructural investigations revealed muscle damage after a strenuous physical exercise. The pathogenesis of the detected autolytic alterations could be related to a local accumulation of lactate, to the ischemic compression syndrome, to an insufficient oxygen supply or to anatomical peculiarities. The greatest functional claim was that fibrillolytic degeneration was capable of being triggered off in the skeletal muscular structure, thereby initiating the release of filament fragments, whose peptides were capable of being depicted as chemotactic signals for leucocytes. The appearance of leucocytes in the muscular tissue suggests that the basic humoral immunity reactions control the cellular cooperation in the muscular tissue. 相似文献
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V Iu Bol'shakov 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2001,87(4):441-447
Long-term depression (LTD) was studied in hippocampal slices obtained from neonatal rats at the synapses between CA3 and CA1 pyramidal neurons. The induction of the LTD required pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated Ca2+ channels with activation of metabotropic glutamate receptors. The expression of this form of LTD is at least partly presynaptic, suggesting the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus applications of arachidonic acid simulate LTD whereas blockade of arachiidonic acid release inhibits LTD. 相似文献
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Toshiyuki Fukada Satoru Yamasaki Keigo Nishida Masaaki Murakami Toshio Hirano 《Journal of biological inorganic chemistry》2011,16(7):1123-1134
The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety
of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory dysfunctions.
Zn homeostasis is regulated through Zn transporters, permeable channels, and metallothioneins. Recent studies highlight Zn’s
dynamic activity and its role as a signaling mediator. Zn acts as an intracellular signaling molecule, capable of communicating
between cells, converting extracellular stimuli to intracellular signals, and controlling intracellular events. We have proposed
that intracellular Zn signaling falls into two classes, early and late Zn signaling. This review addresses recent findings
regarding Zn signaling and its role in physiological processes and pathogenesis. 相似文献
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CYLD in ubiquitin signaling and tumor pathogenesis 总被引:1,自引:0,他引:1
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D. A. Frank 《Molecular medicine (Cambridge, Mass.)》1999,5(7):432-456
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[Purpose]
Mood disorders such as anxiety and depression are prevalent psychiatric illness, but the role of 5HT1A in the anti-depressive effects of exercise has been rarely known yet. We investigated whether long-term exercise affected a depressive-like behavior and a hippocampal 5HT1A receptor-mediated cAMP/PKA/CREB signaling in depression mice model.[Methods]
To induce depressive behaviors, mice were subjected to 14 consecutive days of restraint stress (2 hours/day). Depression-like behaviors were measured by forced swimming test (TST), and anxiety-like behavior was assessed by elevated plus maze (EPM). Treadmill exercise was performed with 19 m/min for 60 min/day, 5 days/week from weeks 0 to 8. Restraint stress was started at week 6 week and ended at week 8. To elucidate the role of 5HT1A in depression, the immunoreactivities of 5HT1A were detected in hippocampus using immunohistochemical technique.[Results]
Chronic/repeated restraint stress induced behavioral anxiety and depression, such as reduced time and entries in open arms in EPM and enhanced immobility time in FST. These anxiety and depressive behaviors were ameliorated by chronic exercise. Also, these behavioral changes were concurrent with the deficit of 5HT1A and cAMP/PKA/CREB cascade in hippocampus, which was coped with chronic exercise.[Conclusion]
These results suggest that chronic exercise may improve the disturbance of hippocampal 5HT1A-regulated cAMP/PKA/CREB signaling in a depressed brain, thereby exerting an antidepressive action. 相似文献15.
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The in vivo effect of a single dose of the neuropathic compound triorthocresyl-phosphate (TOCP) on phosphofructokinase (PFC, E.C. 2.7.1.11) and its relation with the initiation step (inhibition and aging of neuropathy target esterase, NTE) in the TOCP-induced delayed neuropathy have been studied. Hens were treated with a neurotoxic dose of TOCP (500 mg/kg, p.o.) and with a protective compound (Phenylmethanesulfonyl fluoride, PMSF, 30 mg/kg s.c.) in different combinations: TOCP, TOCP + PMSF, PMSF + TOCP and PMSF. PFK activity was determined in brain and sciatic nerve 1, 3, 7 and 15 days after treatment. PFK activity decreased in sciatic nerve 15 days after dosing with TOCP or TOCP + PMSF. When animals were dosed with the protective agent (PMSF) alone or before administering the neurotoxic compound, PFK activity was unaltered and clinical signs of neuropathy were absent. The data presented here suggest that phosphofructokinase is involved in the pathogenesis of the neuropathy induced by TOCP. 相似文献
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Claudette Klein Roger K Sunahara Tracie Y Hudson Tomasz Heyduk Allyn C Howlett 《The Journal of biological chemistry》2002,277(14):11859-11865
Zn(2+) is required as either a catalytic or structural component for a large number of enzymes and thus contributes to a variety of important biological processes. We report here that low micromolar concentrations of Zn(2+) inhibited hormone- or forskolin-stimulated cAMP production in N18TG2 neuroblastoma cells. Similarly, low concentrations inhibited hormone- and forskolin-stimulated adenylyl cyclase (AC) activity in membrane preparations and did so primarily by altering the V(max) of the enzyme. Zn(2+) also inhibited recombinant isoforms, indicating that this reflects a direct interaction with the enzyme. The IC(50) for Zn(2+) inhibition was approximately 1-2 microm with a Hill coefficient of 1.33. The dose-response curve for Zn(2+) inhibition was identical for AC1, AC5, and AC6 as well as for the C441R mutant of AC5 whose defect appears to be in one of the catalytic metal binding sites. However, AC2 displayed a distinct dose-response curve. These data in combination with the findings that Zn(2+) inhibition was not competitive with Mg(2+) or Mg(2+)/ATP suggest that the inhibitory Zn(2+) binding site is distinct from the metal binding sites involved in catalysis. The prestimulated enzyme was found to be less susceptible to Zn(2+) inhibition, suggesting that the ability of Zn(2+) to inhibit AC could be significantly influenced by the coincidence timing of the input signals to the enzyme. 相似文献
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The evolution of hippocampus volume and brain size in relation to food hoarding in birds 总被引:2,自引:0,他引:2
Food‐hoarding birds frequently use spatial memory to relocate their caches, thus they may evolve a larger hippocampus in their brain than non‐hoarder species. However, previous studies testing for such interspecific relationships provided conflicting results. In addition, food hoarding may be a cognitively complex task involving elaboration of a variety of brain regions, even outside of the hippocampus. Hence, specialization to food hoarding may also result in the enlargement of the overall brain. In a phylogenetic analysis of distantly related birds, we studied the interspecific association between food hoarding and the size of different brain regions, each reflecting different resolutions. After adjusting for allometric effects, the relative volume of the hippocampus and the relative size of the entire brain were each positively related to the degree of food‐hoarding specialization, even after controlling for migration and brood parasitism. We also found some significant evidence for the relative volume of the telencephalon being associated with food hoarding, but this relationship was dependent on the approach we used. Hence, neural adaptation to food hoarding may favour the evolution of different brain structures. 相似文献
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