共查询到20条相似文献,搜索用时 15 毫秒
1.
Arttu Jolma Jian Yan Thomas Whitington Jarkko Toivonen Kazuhiro R. Nitta Pasi Rastas Ekaterina Morgunova Martin Enge Mikko Taipale Gonghong Wei Kimmo Palin Juan M. Vaquerizas Renaud Vincentelli Nicholas M. Luscombe Timothy R. Hughes Patrick Lemaire Esko Ukkonen Teemu Kivioja Jussi Taipale 《Cell》2013,152(1-2):327-339
2.
J Pan Q Chen D Willenbring D Mowrey XP Kong A Cohen CB Divito Y Xu P Tang 《Structure (London, England : 1993)》2012,20(9):1463-1469
Highlights? The structure of ketamine-bound GLIC reveals an anesthetic binding site ? The study provides compelling evidence for allosteric inhibition by anesthetics ? Ketamine inhibition on GLIC is similar to competitive antagonist action on nAChRs ? Ketamine directly acts on pLGICs in addition to NMDA receptors 相似文献
3.
Benjamin I. Leach Aravinda Kuntimaddi Charles R. Schmidt Tomasz Cierpicki Stephanie A. Johnson John H. Bushweller 《Structure (London, England : 1993)》2013,21(1):176-183
Highlights? The AF9 AHD is intrinsically disordered ? The AHD recruits AF4, BCoR, Dot1L, and hPC3 by coupled folding and binding ? AF9 binding partners compete for binding to a common site ? Dynamics of the AF4-AF9 complex may facilitate exchange between partners 相似文献
4.
Bret D. Freudenthal William A. Beard Samuel H. Wilson 《Structure (London, England : 1993)》2012,20(11):1829-1837
Highlights? Initial nucleotide binding occurs in the open polymerase complex ? Correct and incorrect nucleotides undergo metal-dependent conformational changes ? Watson-Crick base pairing is sampled upon nucleotide binding ? The stabilization of the correct, but not incorrect, nucleotide deters misinsertion 相似文献
5.
Gang Hu Jianzhao Gao Kui Wang Marcin J. Mizianty Jishou Ruan Lukasz Kurgan 《Structure (London, England : 1993)》2012,20(11):1815-1822
Highlights? Inverse ligand binding prediction is implemented with modern binding site predictors ? Use of just one protein-ligand complex allows accurate identification of other protein targets ? Inverse prediction is effective in finding structurally distant protein targets ? Consensus approach provides improvements 相似文献
6.
Gina L. Razidlo Yu Wang Jing Chen Eugene W. Krueger Daniel D. Billadeau Mark A. McNiven 《Developmental cell》2013,24(6):573-585
Highlights? Dyn2 promotes lamellipodia formation and pancreatic tumor cell migration ? Direct binding between Dyn2 and Vav1 promotes Rac1 activation and migration ? Dyn2 binding protects Vav1 from degradation by the lysosome ? Vav1 is targeted for degradation through an interaction with Hsc70 相似文献
7.
Ramamurthy V Krystek SR Bush A Wei A Emanuel SL Das Gupta R Janjua A Cheng L Murdock M Abramczyk B Cohen D Lin Z Morin P Davis JH Dabritz M McLaughlin DC Russo KA Chao G Wright MC Jenny VA Engle LJ Furfine E Sheriff S 《Structure (London, England : 1993)》2012,20(2):259-269
Highlights? Adnectins interact with targets using multiple binding modes ? Residues outside of the diversified loops can interact with ligand ? Some fixed scaffold residues contribute to the binding energy ? Adnectins can interact with epitopes that may be inaccessible to antibodies 相似文献
8.
David M. Umulis Osamu Shimmi Michael B. O'Connor Hans G. Othmer 《Developmental cell》2010,18(2):260-274
Highlights? Capturing 3D spatiotemporal content of expression data increases model utility ? Embryo geometry shapes signaling; prepatterns compensate in misshapen embryos ? Cell-surface binding proteins compensate for weak ligand/inhibitor/receptor binding ? BMP-mediated patterning is “nearly” scale-invariant 相似文献
9.
Kushol Gupta Joseph E. Curtis Susan Krueger Young Hwang Peter Cherepanov Frederic D. Bushman Gregory D. Van Duyne 《Structure (London, England : 1993)》2012,20(11):1918-1928
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome 相似文献
10.
Highlights? Proteotoxic stress reduces global protein synthesis by influencing elongation ? Proteotoxic stress induces ribosome pausing on mRNAs in the first 50 codons ? Molecular chaperones facilitate translation elongation by binding to nascent chains ? Ribosomes fine tune elongation rate in response to proteotoxic stress 相似文献
11.
Colin A. Smith Catherine A. Shi Matthew K. Chroust Thomas E. Bliska Mark J.S. Kelly Matthew P. Jacobson Tanja Kortemme 《Structure (London, England : 1993)》2013,21(1):54-64
Highlights? Successful design of phosphorylation sites into a globular protein ? Redesigned PDZ domain phosphorylation is associated with local destabilization ? Phosphorylation switches peptide binding function ? Phosphorylation switches peptide recognition specificity 相似文献
12.
Monique Gangloff Christopher J. Arnot Miranda Lewis Nicholas J. Gay 《Structure (London, England : 1993)》2013,21(1):143-153
Highlights? The N-terminal cap of Toll adopts a new fold ? It resembles a duplicated beta hairpin structure with three disulphide bonds ? Toll LRRNT cap is not critical for Spätzle binding ? The first 13 LRRs are sufficient for Spätzle binding 相似文献
13.
Xiao Di Yu Anatoly Dubnovitsky Alex F. Pudney Sheila MacIntyre Stefan D. Knight Anton V. Zavialov 《Structure (London, England : 1993)》2012,20(11):1861-1871
Highlights? Allosteric mechanism controls traffic in the chaperone/usher pathway ? Usher-binding site in free chaperone is conformationally locked ? Subunit binding opens the lock in the chaperone, allowing usher targeting 相似文献
14.
Eigenbrot C Ultsch M Lipari MT Moran P Lin SJ Ganesan R Quan C Tom J Sandoval W van Lookeren Campagne M Kirchhofer D 《Structure (London, England : 1993)》2012,20(6):1040-1050
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1 相似文献
15.
Brian R. Dempsey Atoosa Rezvanpour Ting-Wai Lee Kathryn R. Barber Murray S. Junop Gary S. Shaw 《Structure (London, England : 1993)》2012,20(10):1737-1745
Highlights? S100A10, annexin A2, and AHNAK are involved in membrane repair ? The AHNAK binding region forms a coiled structure ? Both S100A10 and annexin A2 make contacts to AHNAK and are necessary for binding ? The asymmetric architecture provides a model for AHNAK translocation to the membrane 相似文献
16.
Sonja Baumli Alison J. Hole Lan-Zhen Wang Martin E.M. Noble Jane A. Endicott 《Structure (London, England : 1993)》2012,20(10):1788-1795
Highlights? The CDK9 C-terminal tail is important for the catalytic mechanism ? CDK9 phosphorylates the CTD in a nonprocessive manner ? The CDK9 tail folds over the ATP binding site during the catalytic cycle 相似文献
17.
Cho Yeow Koh Jessica E. Kim Sayaka Shibata Ranae M. Ranade Mingyan Yu Jiyun Liu J. Robert Gillespie Frederick S. Buckner Christophe L.M.J. Verlinde Erkang Fan Wim G.J. Hol 《Structure (London, England : 1993)》2012,20(10):1681-1691
Highlights? Complexes of MetRS from T. brucei with its substrate, intermediate, and inhibitors ? In crystals, substrate-bound MetRS undergoes extensive changes with inhibitor binding ? The inhibitor-bound conformation is surprisingly similar to the ligand-free state ? This indicates inhibitor binding occurs via conformational selection not by induced fit 相似文献
18.
Marko Mocibob Nives Ivic Marija Luic Ivana Weygand-Durasevic 《Structure (London, England : 1993)》2013,21(4):614-626
Highlights? The crystal structure of the aa:CP ligase in complex with carrier protein was solved ? The interaction relies on the idiosyncratic α-helix of the aa:CP ligase ? The complex represents a unique mode of carrier protein recognition and binding ? The mechanism of amino acid attachment to carrier protein is discussed 相似文献
19.
Helen Hwang Noah Buncher Patricia L. Opresko Sua Myong 《Structure (London, England : 1993)》2012,20(11):1872-1880
Highlights? POT1 binds the telomere overhang sequentially one OB fold at a time ? POT1 binding exhibits 3′ to 5′ directionality ? POT1-TPP1N induces dynamic folding and unfolding of telomeric overhang ? POT1-TPP1N slides back and forth on the telomeric overhang 相似文献
20.
Nir Kalisman Gunnar F. Schröder Michael Levitt 《Structure (London, England : 1993)》2013,21(4):540-549
Highlights? CCT subunit types can be identified in crystallographic data, even at low resolutions ? Actin and tubulin both bind around CCT6 ? ATP hydrolysis and substrate binding are partitioned in the CCT particle 相似文献