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1.
A new neo-clerodane diterpenoid, teuchamaedrin C, has been isolated from the aerial parts of Teucrium chamaedrys. Its structure, (12S,18S)-15,16-epoxy-neo-clerodane-13(16)14-dien-19,20-olide-18,6β-hemiacetal, was established by spectroscopic and chemical means. In addition, the previously known diterpenoids 6α-hydroxyteuscordin and dihydroteugin were isolated from the same source. 相似文献
2.
From the aerial part of Teucrium chamaedrys a new neo-clerodane diterpenoid, dihydroteugin, has been isolated, besides the previously known diterpenoids teucrin A and teugin. The structure of dihydroteugin, (12S)-15,16-epoxy-2β,6β-dihydroxy-neo-cleroda-13(16), 14-diene-18,19:20,12-diolide, was established by chemical and spectroscopic means and by partial synthesis from teugin. 相似文献
3.
Giuseppe Savona Franco Piozzi Orietta Servettaz Benjamín Rodríguez Francisco Fernández-Gadea Manuel Martín-Lomas 《Phytochemistry》1984,23(4):843-848
From the aerial part of Teucrium flavum subsp. glaucum a new neo-clerodane diterpenoid, teuflavin, and a new 19-nor-neo-clerodane glucoside, teuflavoside, have been isolated, besides the previously known diterpene teuflin. The structures of teuflavin (19-acetoxy-4α,18:15,16-diepoxy-6β-hydroxy-3-keto-neo-cleroda-13(16),14-diene-20,ξ,12S-hemiacetal) and teuflavoside (18-acetoxy-15,16-epoxy-19-nor-neo-cleroda-4,13(16),14-trien-20,12S-olid-6β-yl-2′-O-acetyl-β-d-glucopyranoside) were established by chemical and spectroscopic means and by correlation with known compounds. In addition, the previously known flavone salvigenin has also been obtained from the same source. 相似文献
4.
Giuseppe Savona Maurizio Bruno Mariapia Paternostro José L. Marco Benjamín Rodríguez 《Phytochemistry》1982,21(10):2563-2566
A new neo-clerodane diterpenoid, salviacoccin, was isolated from the aerial part of Salvia coccinea. Its structure, 15,16-epoxy-10-hydroxy-neo-cleroda-2,7,13(16), 14-tetraene-17,12R:18,19-diolide, was established by chemical and spectroscopic means and by comparison with closely related compounds. 相似文献
5.
Jose L. Marco Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1982,21(10):2567-2569
From the aerial parts of Teucrium scorodonia the previously known diterpenoid teupolin I and the flavone luteolin have been isolated. In addition, three new neo-clerodane derivatives have also been obtained from the same source. The structures of these new natural diterpenoids have been established by chemical and spectroscopic means and by correlation with known products. 相似文献
6.
María C. García-Alvarez Mashooda Hasan Antonio Michavila Francisco Fernández-Gadea Benjamín Rodríguez 《Phytochemistry》1985,25(1):272-274
A new neo-clerodane derivative, epoxysalviacoccin, has been isolated from the aerial part of Salvia plebeia, together with the previously known diterpenoid salviacoccin. The structure of epoxysalviacoccin, 2β,3β; 15,16-diepoxy-10β-hydroxy-neo-cleroda-7,13(16),14-triene-17,12R; 18,19-diolide, has been established by spectroscopic means and by partial synthesis from salviacoccin. 相似文献
7.
Maurizio Bruno Giuseppe Savona Conrad Pascual Benjamín Rodríguez 《Phytochemistry》1981,20(9):2259-2261
From the aerial part of Teucrium fragile a new neo-clerodane diterpenoid, teugin, has been isolated. Its structure, 15,16-epoxy- 2β,6β-dihydroxy-neo-cleroda-3,13(16),14-triene-18,19:20,12S-diolide, was established mainly by spectroscopic means. 相似文献
8.
From the aerial parts of Teucrium scordium a new neo-clerodane diterpenoid, 2-keto-19-hydroxyteuscordin, has been isolated, besides the previously known diterpenoids teucrin E and teucrin H4. The structure of 2-keto-19-hydroxyteuscordin, (12S)-15,16-epoxy-2-keto-19-hydroxy neo-clerodane-13(16),14-dien-18β,6β:20,12-diolide, was established by chemical and spectroscopic means. 相似文献
9.
The structure and absolute configuration of salvifaricin, a neo-clerodane diterpenoid isolated from Salvia farinacea, have been firmly established by extensive NOE experiments and by chemical correlation with salvifarin, another diterpenoid isolated from the same source. These results slightly modify the structure previously assigned to the compound. 相似文献
10.
Liliana Eguren José Fayos Aurea Perales Giuseppe Savona Benjamín Rodríguez 《Phytochemistry》1984,23(2):466-467
The structure and absolute configuration of salvifarin, a neo-clerodane diterpenoid isolated from Salvia farinacea, have been established by X-ray diffraction analysis. This result modifies the structure previously assigned to this compound. 相似文献
11.
María C. García-Alvarez José L. Marco Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1982,21(10):2559-2562
From the aerial part of Teucrium pyrenaicum three new neo-clerodane diterpenoids have been isolated. Their structures, 3β-acetoxy-4α,18:12S,2OS: 15,16:19, 2OS-tetraepoxy-neo-cleroda-13(16),14-dien-6-one (teupyrenone), 3β,6α,19-triacetoxy- 4α,18:15,16-diepoxy-neo-cleroda-13(16),14-dien-20,12S-olide (teupyreinin), and 3β, 6α,19,2OS-tetra-acetoxy-4α,18:12S,2OS: 15,16-triepoxy-neo-cleroda-13(16), 14-diene (teupyreinidin), were established mainly by spectroscopic means. 相似文献
12.
Juan A. Hueso-Rodríguez Francisco Fernández-Gadea Conrad Pascual Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1985,25(1):175-180
From the aerial part of Teucrium lanigerum, six new neo-clerodane diterpenoids, 7,8-dehydroeriocephalin, teulanigeral, teulanigin, 20-epi-teulanigin, teulanigerin and teulanigeridin, have been isolated. The first of these, 7,8-dehydroeriocephalin, is a natural substance, whereas the other compounds were isolated as their acetyl derivatives after acetylation of an inseparable mixture of natural diterpenoids. The structures of these substances were established mainly by spectroscopic means and, in the case of 7,8-dehydroeriocephalin, by partial synthesis from eriocephalin. 相似文献
13.
Giuseppe Savona Maurizio Bruno Franco Piozzi Orietta Servettaz Benjamín Rodríguez 《Phytochemistry》1984,23(4):849-852
From the aerial part of Teucrium massiliense three new neo-clerodane diterpenoids, deacetylajugarin-II, teumassilin and 6,19-diacetylteumassilin, have been isolated, besides the previously known diterpenes montanin C and teucjaponin A. The structures of deacetylajugarin-II (4α,18-epoxy-6α,19-dihydroxy-neo-clerodan-13-en-15,16-olide), teumassilin (4α,18:15,16-diepoxy-6α,12S,19-trihydroxy-neo-cleroda-13(16),14-diene) and 6,19-diacetylteumassilin (6α,19-diacetoxy-4α,18:15,16-diepoxy-12S-hydroxy-neo-cleroda-13(16),14-diene) were established by chemical and spectroscopic means. In addition, the previously known flavones salvigenin and cirsimaritin have also been obtained from the same source. 相似文献
14.
From the aerial part of Rabdosia umbrosa var. latifolia, a new diterpenoid, rabdolatifolin, was isolated together with the known compounds, shi 相似文献
15.
Francisco Férnandez-Gadea Benjamín Rodríguez Giuseppe Savona Franco Piozzi 《Phytochemistry》1984,23(5):1113-1118
From the aerial part of Teucrium lanigerum two new neo-clerodane diterpenoids, 20-deacetyleriocephalin and isoeriocephalin, have been isolated, together with the previously known diterpene eriocephalin. The structures of 20-deacetyleriocephalin [19-acetoxy 4α,18:15,16-diepoxy-7α-hydroxy-6-keto-neo-cleroda-13(16),14-diene-20S,12S-hemiacetal] and isoeriocephalin [19-acetoxy-4α,18:15,16-diepoxy-6α-hydroxy-7-keto-neo-cleroda-13(16),14-diene (20-acetyl)-20S,12S-hemiacetal] were established by chemical and spectroscopic means and by correlation with known compounds. 相似文献
16.
Peter Malakov Georgi Papanov Jasmin Jakupovic Michael Grenz Ferdinand Bohlmann 《Phytochemistry》1985,24(10):2341-2343
From the aerial part of Leonurus cardiaca a new labdane diterpenoid, leocardin, has been isolated and its structure was established by spectroscopic and chemical means. It has been shown to be 8β-acetoxy-9α,13α,15,16-bisepoxy-15-hydroxy-7-oxo-labdan-6β,19-olide present as a C-15 epimeric mixture. 相似文献
17.
María-Cruz Rodríguez José Barluenga Giuseppe Savona Franco Piozzi Orietta Servettaz Benjamin Rodriguez 《Phytochemistry》1984,23(7):1465-1469
A new neo-clerodane diterpenoid, isoteuflidin, was isolated from the aerial part of Teucrium chamaedrys. Its structure, 15,16-epoxy-3β-hydroxy-19 相似文献
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20.
Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were Isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1D and
2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-4 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with ICso values in the range of 3.5-6.7 μM. 相似文献