共查询到20条相似文献,搜索用时 15 毫秒
1.
Plasma carotenoid concentrations of incubating American kestrels (Falco sparverius) show annual,seasonal, and individual variation and explain reproductive outcome
下载免费PDF全文
![点击此处可从《Biological journal of the Linnean Society. Linnean Society of London》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Elizabeth C. Sassani Christeena Sevy Erin H. Strasser Alexandra M. Anderson Julie A. Heath 《Biological journal of the Linnean Society. Linnean Society of London》2016,117(3):414-421
In wild birds, the proximate and ultimate factors that affect circulating carotenoid concentrations remain poorly understood. We studied variation in plasma carotenoid concentrations across several scales: annual, seasonal, pair, territory and individual, and evaluated whether plasma carotenoid concentrations explained reproductive outcome of wild American kestrels (Falco sparverius). We sampled plasma carotenoid concentrations of 99 female and 80 male incubating kestrels from April to June in 2008 to 2012. Plasma carotenoid concentrations were explained by an interaction between year and sex, date, and random effects for pair and individual identity. In general, plasma carotenoid concentrations of males were significantly higher than females, but this depended on year. Within a breeding season, earlier nesting kestrels had higher carotenoid concentrations than later nesting kestrels, a pattern that is coincident with seasonal trends in local fitness. Pair and individual identity explained variation in carotenoid concentrations suggesting that carotenoid concentrations of mated birds were correlated, and some individuals consistently maintained higher carotenoid levels than others. Male carotenoid concentrations were positively associated with number of young fledged per pair. These results are consistent with the hypothesis that higher quality individuals have higher carotenoid levels compared to lower quality individuals, despite annual variations in carotenoid availability. 相似文献
2.
Coppedè F 《Current Genomics》2010,11(4):246-260
Alzheimer's disease (AD) represents the most common form of dementia in the elderly, characterized by progressive loss of memory and cognitive capacity severe enough to interfere with daily functioning and the quality of life. Rare, fully penetrant mutations in three genes (APP, PSEN1 and PSEN2) are responsible for familial forms of the disease. However, more than 90% of AD is sporadic, likely resulting from complex interactions between genetic and environmental factors. Increasing evidence supports a role for epigenetic modifications in AD pathogenesis. Folate metabolism, also known as one-carbon metabolism, is required for the production of S-adenosylmethionine (SAM), which is the major DNA methylating agent. AD individuals are characterized by decreased plasma folate values, as well as increased plasma homocysteine (Hcy) levels, and there is indication of impaired SAM levels in AD brains. Polymorphisms of genes participating in one-carbon metabolism have been associated with AD risk and/or with increased Hcy levels in AD individuals. Studies in rodents suggest that early life exposure to neurotoxicants or dietary restriction of folate and other B vitamins result in epigenetic modifications of AD related genes in the animal brains. Similarly, studies performed on human neuronal cell cultures revealed that folate and other B vitamins deprivation from the media resulted in epigenetic modification of the PSEN1 gene. There is also evidence of epigenetic modifications in the DNA extracted from blood and brains of AD subjects. Here I review one-carbon metabolism in AD, with emphasis on possible epigenetic consequences. 相似文献
3.
CAROLINE ISAKSSON MARIA VON POST STAFFAN ANDERSSON 《Biological journal of the Linnean Society. Linnean Society of London》2007,92(3):521-527
In many birds, carotenoids have dual functions as irreversible plumage pigments and as physiologically essential vitamins and antioxidants. They must be obtained through the diet and may therefore be a limiting resource, a constraint that is likely to vary with factors such as sex, habitat, and time of year. In the present study, we investigated signs of carotenoid limitation in great tits, Parus major , in relation to sex, season, year, and within an urban versus a rural habitat. The two main carotenoids, lutein and zeaxanthin, were analysed by high-performance liquid chromatography in the plasma and in the yellow carotenoid-based breast feathers. We found that plasma carotenoid concentrations were significantly influenced by sex, season, and year, but not by urban versus rural habitat. At moult, plasma concentration was positively correlated with feather pigmentation, independent of body condition and sex. During the breeding season, however, circulating carotenoid concentrations were negatively related to the feather pigmentation (i.e. from previous autumn moult). We suggest that great tits are carotenoid deprived before leaf emergence, and that carotenoid utilization and limitations are sex-specific, but that there are neither any obvious honesty-maintaining costs of pigmentation, nor any fitness consequences of the colour variation. © 2007 The Linnean Society of London, Biological Journal of the Linnean Society , 2007, 92 , 521–527. 相似文献
4.
Matthew S. Ward Da You Zhao Paul S. Bernstein 《Journal of ocular biology, diseases, and informatics》2008,1(1):12-18
The carotenoids lutein and zeaxanthin are believed to protect the human macula by absorbing blue light and quenching free radicals. Intestinal malabsorption syndromes such as celiac and Crohn’s disease are known to cause deficiencies of lipid-soluble nutrients. We hypothesized that subjects with nutrient malabsorption syndromes will demonstrate lower carotenoid levels in the macula and blood, and that these lower levels may correlate with early-onset maculopathy. Resonance Raman spectrographic (RRS) measurements of macular carotenoid levels were collected from subjects with and without a history of malabsorption syndromes. Carotenoids were extracted from serum and analyzed by high performance liquid chromatography (HPLC). Subjects with malabsorption (n = 22) had 37% lower levels of macular carotenoids on average versus controls (n = 25, P < 0.001). Malabsorption was not associated with decreased serum carotenoid levels. Convincing signs of early maculopathy were not observed. We conclude that intestinal malabsorption results in lower macular carotenoid levels. 相似文献
5.
Susana I. Peluc Wendy L. Reed Penelope Gibbs Kevin J. McGraw 《Journal of avian biology》2014,45(4):334-344
Maternal resources deposited in eggs can affect the development of several offspring phenotypic traits and result in trade‐offs among them. For example, maternal androgens in eggs may be beneficial to offspring growth and competitive ability, but detrimental to immunocompetence and oxidative stress. In contrast, maternal antioxidants in eggs may be beneficial if they mitigate oxidative stress and immunosuppressive effects of androgens. We investigated possible interactive effects of maternal steroids and carotenoids on aspects of offspring physiology and phenotype, by simultaneously manipulating levels of androgens (via gonadotropin‐releasing hormone, GnRH‐challenges) and carotenoids (via diet supplementation) in captive female Japanese quail Coturnix japonica during egg laying. Carotenoid supplementation of hens, which elevates yolk concentrations of carotenoid and vitamins A and E, enhanced egg hatching success, offspring survival to age 15 d, and size of the bursa of Fabricius in offspring. In contrast, repeated maternal GnRH challenges, which elevated yolk testosterone concentrations, enhanced offspring neonatal size, but negatively affected bursa size. However, interaction among the treatments suggests that the positive effect of maternal carotenoid supplementation on plasma bactericidal capacity was mediated by maternal GnRH challenges. Chicks originating from carotenoid‐supplemented hens were less immunosuppressed than those originating from carotenoid‐supplemented + GnRH‐challenged hens, which were less immunosuppressed than chicks from GnRH‐challenged females not supplemented with carotenoids. Females availability of carotenoid enriched diets allows them to enhance the development of offspring immune system via carotenoids and vitamins deposited in egg yolks and offset detrimental effects of androgens deposited by GnRH‐challenged females. 相似文献
6.
Anne Peters Mark L. Roberts Ralf H. J. M. Kurvers Kaspar Delhey 《Journal of avian biology》2012,43(4):362-368
A number of mechanisms are responsible for producing the variation in natural colours, and these need not act in isolation. A recent hypothesis states that carotenoid‐based coloration, in addition to carotenoid availability, is also enhanced by elevated levels of circulating testosterone (T). This has only been tested for carotenoid‐coloured bare parts in birds. We performed an experimental manipulation of T levels and examined the effects on the yellow carotenoid‐based breast plumage in captive yearling blue tits Cyanistes caeruleus, of which half received a diet supplemented with carotenoids. T treatment resulted in elevated plasma T compared to controls and carotenoid supplementation strongly increased plasma carotenoid levels. T treatment resulted in an additional increase in plasma carotenoid levels but only in the carotenoid‐supplemented males. Carotenoid supplementation resulted in more intense breast colour (carotenoid chroma), as expected. However, there was no effect of testosterone on plumage coloration at either dietary carotenoid level. Our results suggest that T can cause an increase in plasma carotenoid concentration, but that this does not necessarily lead to improved carotenoid‐based plumage coloration. 相似文献
7.
The yellow carotenoid-based plumage coloration of great tit Parus major nestlings is found to be paler in polluted and urban environments. Because carotenoid pigmentation is often considered to be a condition dependent trait in birds we wanted to find out whether food-limitation and poor nestling condition could explain the pale plumage colour in a polluted area. P. major nestlings were supplemented with variable diets along a well known heavy metal pollution gradient around a copper smelter: two food treatments with carotenoids, one food treatment with little carotenoid and one unsupplemented control. Our field experiment showed that nestlings in the polluted area grew better with carotenoid rich diets, while such effect was not found in the unpolluted area. Nestlings showed higher plasma carotenoid (lutein) levels and higher plumage carotenoid chroma values in the unpolluted area than in the polluted area. However, plasma lutein levels or plumage colour were not associated with heavy metal levels in nestling faeces (a proxy for dietary exposure). Our results provide only weak evidence for carotenoid-based colouration to be condition-dependent in great tit nestlings as we found a positive relationship between body mass and carotenoid chroma in the non-supplemented control group only. The positive relationship between body mass and plumage colour intensity is more likely to be produced by the fact that good availability of caterpillars, an important food source for P. major, also means a good availability of carotenoids to nestlings. Our results suggest that main reason for pale nestling plumage in the polluted area is lower quality invertebrate food, and not nutrition-related oxidative stress. 相似文献
8.
Simkin AJ Labouré AM Kuntz M Sandmann G 《Zeitschrift für Naturforschung. C, Journal of biosciences》2003,58(5-6):371-380
Physiological conditions which lead to changes in total carotenoid content in tomato plantlets were identified. Carotenoid levels were found to increase after the onset of a dark period during a normal 24 h cycle. This rapid initial increase is followed by a steady decrease in carotenoid content throughout the night. A decrease in the expression of several carotenogenic genes, namely pds, zds (carotenoid desaturases) and ptox (plastid terminal oxidase), was observed following the removal of the light (when carotenoid content is at its highest). An increase in gene expression was observed before the return to light for pds and zds (when carotenoid levels were at their lowest), or following the return to light for ptox. The phytoene desaturation inhibitor norflurazon leads to a decrease coloured carotenoid content and, in the light, this correlated with pds and zds gene induction. In the dark, norflurazon treatment led to only a weak decrease in carotenoid content and only a small increase in pds and zds gene expression. The striking absence of phytoene accumulation under norflurazon treatment in the dark suggests a down-regulation of carotenoid formation in darkness However, prolonged dark conditions, or treatment with photosynthetic inhibitors, surprisingly led to higher carotenoid levels, which correlated with decreased expression of most examined genes. In addition to light, which acts in a complex way on carotenoid accumulation and gene expression, our results are best explained by a regulatory effect of carotenoid levels on the expression of several biosynthetic genes. In addition, monitoring of protein amounts for phytoene desaturase and plastid terminal oxidase (which sometimes do not correlate with gene expression) indicate an even more complex regulatory pattern. 相似文献
9.
van Der Veen IT 《Journal of evolutionary biology》2005,18(4):992-999
Carotenoid reserves in copepods seem costly in terms of predation risk because they make individuals conspicuous. However, carotenoids also seem to play an important role in immune defence as free radical scavengers. To test whether predation risk influences carotenoid levels and whether changes in carotenoid levels are related to changes in immune defence, I examined individual changes in large carotenoid and other lipid droplets upon exposure to predation risk and subsequent exposure to parasites in the copepod Macrocyclops albidus. Copepods reduced carotenoid reserves upon exposure to predators, through which they potentially avoided the costs of being conspicuous under predation risk. Thus, the size of carotenoid reserves is a plastic trait. Such a decrease in carotenoid reserves may also have a negative impact on the copepods' immune system as individuals that decreased their reserves suffered higher parasite prevalence upon exposure to the cestode Schistocephalus solidus. These results suggest that carotenoid reserves may be individually optimized to trade-off each individual's unique costs (predation risk) and benefits (immune defence) of having these reserves. 相似文献
10.
Pérez-Rodríguez L Alonso-Alvarez C Viñuela J 《Physiological and biochemical zoology : PBZ》2007,80(2):250-254
Carotenoid pigments have become a central subject of research on animal signaling systems during the past decade. Thus, measurement of plasma carotenoid levels is widespread in the literature. Many plasma biochemical parameters tend to vary with the hour of sampling, which may be an important source of sampling error. However, little is known about this kind of variation for circulating carotenoids. With a sampling protocol that allowed us to separately analyze the effect of sampling hour and repeated blood extraction at the within-individual level, we evaluated the effect of these two parameters on plasma carotenoid concentration in captive red-legged partridges (Alectoris rufa). The hour of sampling did not show a significant influence on carotenoid variability. Nevertheless, carotenoid levels significantly decreased as a result of repeated sampling. In fact, carotenoid variability was positively related to hematocrit values, which also decreased throughout the experiment. Furthermore, the effect was evident from the second sampling event. These results suggest that blood samples for carotenoid analysis may be obtained at random during the daytime with no serious risk of adding variance to data obtained. However, the effect of hemodilution associated with repeated blood extraction should be carefully considered in those studies involving repeated sampling. 相似文献
11.
Thomas T.Y. Wang Alison J. Edwards Beverly A. Clevidence 《The Journal of nutritional biochemistry》2013,24(8):1538-1546
The mechanisms as well the genetics underlying the bioavailability and metabolism of carotenoids in humans remain unclear. To begin to address these questions, we used cluster analysis to examine individual temporal responses of plasma carotenoids from a controlled-diet study of subjects who consumed carotenoid-rich beverages. Treatments, given daily for 3 weeks, were watermelon juice at two levels (20-mg lycopene, 2.5-mg β-carotene, n=23 and 40-mg lycopene, 5-mg β-carotene, n=12) and tomato juice (18-mg lycopene, 0.6-mg β-carotene, n=10). Cluster analysis revealed distinct groups of subjects differing in the temporal response of plasma carotenoids and provided the basis for classifying subjects as strong responders or weak responders for β-carotene, lycopene, phytoene and phytofluene. Individuals who were strong or weak responders for one carotenoid were not necessarily strong or weak responders for another carotenoid. Furthermore, individual responsiveness was associated with genetic variants of the carotenoid metabolizing enzyme β-carotene 15,15'-monooxygenase 1. These results support the concept that individuals absorb or metabolize carotenoids differently across time and suggest that bioavailability of carotenoids may involve specific genetic variants of β-carotene 15,15'-monooxygenase 1. 相似文献
12.
Iyanda AA Anetor JI Oparinde DP Adeniyi FA 《Nigerian journal of physiological sciences》2010,25(2):129-134
Methionine is an effective antidote in the treatment of paracetamol-induced toxicity but at large doses it has been reported to induce or aggravate a number of pathological conditions. It also alters plasma levels of many vital elements and molecules. This study was designed to identify if the alteration observed for antioxidant vitamins and minerals especially at sub-toxic and toxic levels of exposure in our earlier study of 24-hour exposure period may warrant trace elements supplementation. This was investigated by carrying out a 48-hour study to test the ability of a living organism to restore homeostasis of these vital molecules and elements. The levels of antioxidant minerals and vitamins were estimated in the serum samples obtained from adult male Wistar rats exposed to paracetamol tablets. At 100 mg\kg BW (body weight) vitamin A, niacin, riboflavin, selenium and manganese were not significantly different from the control group. Moreover at 350 mg\kg, all these indices except zinc were not significantly different in the exposed group compared with controls whereas at 1000 mg\kg level of exposure manganese, selenium and vitamin E were not significantly decreased at the end of 48 hours of exposure but copper, niacin and vitamin A were significantly increased in the exposed group compared with the controls. These results suggest that with time the body may be capable of bringing about restoration of the levels of some of these elements\vitamins. This was more evident at 350 mg\kg level of exposure than a higher dose of 1000 mg\kg level.Keywords: Paracetamol formulation, Vitamins, Trace elements. 相似文献
13.
Bernstein PS Zhao DY Sharifzadeh M Ermakov IV Gellermann W 《Archives of biochemistry and biophysics》2004,430(2):163-169
There is growing evidence that high levels of the macular xanthophyll carotenoids lutein and zeaxanthin may be protective against visual loss from age-related macular degeneration. To study this protective effect further, it is important to measure macular carotenoid levels noninvasively in a wide variety of subjects. We have developed and validated resonance Raman spectroscopy as a sensitive and specific objective method to measure macular carotenoid levels in the living human eye. In this minireview, the principles and implementation of ocular carotenoid resonance Raman spectroscopy are reviewed, and the results of observational cross-sectional studies and of prospective supplementation studies on subjects with and without macular pathology are summarized. We have recently extended this technology to an imaging mode which will further enhance our understanding of the roles of lutein and zeaxanthin in normal macular function and in the prevention of age-related visual loss. 相似文献
14.
Light sensitivity of plastids and plastid pigments present in the albescent maize mutant 总被引:4,自引:2,他引:2
下载免费PDF全文
![点击此处可从《Plant physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dark grown albescent corn seedlings are deficient in colored carotenoids but accumulate phytoene, phytofluene and an unidentified substance in the carotenol fraction. They bleach upon exposure to bright light and appear albino. Seedlings grown under low level incandescent light are normal in appearance and contain almost as much colored carotenoid as control seedlings. The existing leaf tissue of seedlings grown under low level light does not bleach upon exposure to bright light. The enhanced carotenoid synthesis and stabilization of plastids is not affected by brief illumination with red light but requires several hours of low level incandescent light. 相似文献
15.
Homer S Black 《Photochemical & photobiological sciences》2004,3(8):753-758
Beta-carotene is a strong singlet oxygen quencher and antioxidant. Epidemiologic studies have implied that an above average intake of the carotenoid might reduce cancer risks. Earlier studies found that the carotenoid, when added to commercial closed-formula rodent diets, provided significant photoprotection against UV-carcinogenesis in mice. Clinical intervention trials found that beta-carotene supplementation evoked no change in incidence of nonmelanoma skin cancer. However, when smokers were supplemented with the carotenoid a significant increase in lung cancer resulted. Recently, employing a beta-carotene supplemented semi-defined diet, not only was no photoprotective effect found, but significant exacerbation of UV-carcinogenesis occurred. Earlier, a mechanism, based upon redox potential of interacting antioxidants, was proposed in which beta-carotene participated with vitamins E and C to efficiently repair oxy radicals and, thus, thought to provide photoprotection. In this schema, alpha-tocopherol would first intercept an oxy radical. In terminating the radical-propagating reaction, the tocopherol radical cation is formed which, in turn, is repaired by beta-carotene to form the carotenoid radical cation. This radical is repaired by ascorbic acid (vitamin C). As the carotenoid radical cation is a strongly oxidizing radical, unrepaired it could contribute to the exacerbating effect on UV-carcinogenesis. Thus, vitamin C levels could influence the levels of the pro-oxidant carotenoid radical cation. However, when hairless mice were fed beta-carotene supplemented semi-defined diet with varying levels of vitamin C (0-5590 mg kg(-1) diet) no effect on UV-carcinogenesis was observed. Lowering alpha-tocopherol levels did result in further increase of beta-carotene exacerbation, suggesting beta-carotene and alpha-tocopherol interaction. It was concluded that the non-injurious or protective effect of beta-carotene found in the closed-formula rations might depend on interaction with other dietary factors that are absent in the semi-defined diet. At present, beta-carotene use as a dietary supplement for photoprotection should be approached cautiously. 相似文献
16.
Does light exposure make plant litter more degradable? 总被引:4,自引:0,他引:4
Bente Foereid Jessica Bellarby Wolfram Meier-Augenstein Helen Kemp 《Plant and Soil》2010,333(1-2):275-285
Many field experiments have indicated that litter decomposition in semi-arid areas may be partly or fully controlled by photodegradation. We devised a study to test our hypothesis that light exposure makes plant litter more degradable. Dry, senescent, aboveground plant litter from Miscanthus x giganteus was exposed to light including ultraviolet (UV) radiation for various lengths of time from 0 to 289 days. Weight loss was measured after exposure and appeared to be modest and did not increase with time of exposure. The litter of the longest and shortest exposure time as well as controls were then incubated with soil and moisture for 35 days and CO2 and N2O production were measured. The longest exposed litter degraded much faster than any other treatment during incubation with moisture, about twice as fast as the unexposed control. The shortest exposed however, degraded only slightly faster than the unexposed control. This suggests that increasing litter degradability is a more important mechanism for photodegradation than direct light-induced mass loss. N2O production from decomposition of the exposed litter was high in the beginning, suggesting that nitrogen may be released quickly. The mechanism is probably that light exposure leaves the nitrogen in plant litter easily available to microbial utilisation upon wetting. Such a mechanism might play an important role for nutrient cycling in semi-arid areas. 相似文献
17.
While rodents and other mammals have traditionally served as models for studying carotenoid physiology, many wild animals from a variety of other taxa utilize carotenoids for self-maintenance and reproduction and accumulate far greater concentrations than those found in mammals. Though we have basic understandings of the control and value of carotenoids in some wild animal systems, many gaps remain. For example, parasites and pathogens impose severe survival constraints on free-ranging organisms, but little is known of how carotenoids work in concert with the immune system to combat natural infectious challenges. Furthermore, due to the high mortality rate from which many young animals suffer, health and carotenoid status during the early stages of development may be critical to survival. The relative importance of dietary versus physiological mechanisms for carotenoid uptake has also been understudied in the wild. To begin to shed light on these issues, we studied relationships between dietary and tissue carotenoids, hematological immune parameters, and endoparasitism of wild mallard (Anas platyrhynchos) ducklings at a variety of ages. Lutein, zeaxanthin, β-cryptoxanthin, β-carotene, and canthaxanthin were the most common carotenoids in liver, plasma, and gut contents. We found that, early in development (when food intake is limited), carotenoids were comparatively concentrated in internal tissue (e.g., liver), presumably a carry-over from maternal contributions in yolk, but as ducklings approached independence (and increasingly fed on their own) concentrations were greatest in gut contents. Canthaxanthin concentrations were lower in the plasma and liver of older individuals compared to younger ducklings, even though gut canthaxanthin concentration did not change with age. Additionally, β-carotene was nearly absent from circulation, despite moderate levels within the gut, suggesting a high rate of conversion to retinol. Using principal components analysis, we revealed a correlation between an increased ability to assimilate dietary carotenoids and lower levels of chronic stress (as assessed by lower heterophil-to-lymphocyte ratios) and a correlation between a reduced carotenoid status and increased investment in the immune system (as assessed by higher total leukocyte count). We also found that individuals without parasites had an overall reduced carotenoid status. Thus, we demonstrate age-specific differences in carotenoid allocation in growing animals from a precocial bird species and provide correlational evidence that parasitism and health in wild animals are related to carotenoid status and assimilation ability. 相似文献
18.
There are no literature references describing the effect of consumption of Aloe vera liquid preparations on the absorption of water- or fat-soluble vitamins. There is a very large population worldwide which consume vitamins and many people also consume Aloe. Thus we report the effect of Aloe on the human absorption of vitamins C and E, the most popular vitamin supplements. The plasma bioavailability of vitamins C and E were determined in normal fasting subjects, with eight subjects for vitamin C and ten subjects for vitamin E. In a random crossover design, the subjects consumed either 500 mg of ascorbic acid or 420 mg of vitamin E acetate alone (control), or combined with 2 oz of two different Aloe preparations (a whole leaf extract, or an inner fillet gel). Blood was collected periodically up to 24 h after consumption. Plasma was analyzed for ascorbate and tocopherol by HPLC with UV detection. There was no significant difference in the areas under the plasma ascorbate–time curves among the groups sincerely due to large differences within the groups. For comparative purposes the control area was 100%. The Aloe Gel area was 304%, and Aloe Whole Leaf 80%. Only Aloe Gel caused a significant increase in plasma ascorbate after 8 and 24 h. For vitamin E, the results for the relative areas were control 100%, Gel 369%, and Leaf (198%). Only the Aloes produced a significant increase in plasma tocopherol after 6 and 8 h. Both Aloes were significantly different from the control after 8 h. Aloe Gel was significantly different from the baseline after 24 h. The Aloes slowed down the absorption of both vitamins with maximum concentrations 2–4 h later than the control. There was no difference between the two types of Aloe. The results indicate that the Aloes improve the absorption of both vitamins C and E. The absorption is slower and the vitamins last longer in the plasma with the Aloes. Aloe is the only known supplement to increase the absorption of both of these vitamins and should be considered as a complement to them. 相似文献
19.
Miyazawa T Nakagawa K Kimura F Satoh A Miyazawa T 《Bioscience, biotechnology, and biochemistry》2011,75(9):1856-1858
A randomized, double-blind human trial was conducted to assess the effect on the plasma carotenoid concentration of 4- or 12-week astaxanthin supplementation (1 or 3 mg/d) of 20 Japanese middle-aged and senior subjects. The plasma carotenoid concentration was significantly higher after the astaxanthin supplementation than that before in both the 1 mg/d (10 subjects) and 3 mg/d (10 subjects) groups. 相似文献
20.
《Bioscience, biotechnology, and biochemistry》2013,77(9):1856-1858
A randomized, double-blind human trial was conducted to assess the effect on the plasma carotenoid concentration of 4- or 12-week astaxanthin supplementation (1 or 3 mg/d) of 20 Japanese middle-aged and senior subjects. The plasma carotenoid concentration was significantly higher after the astaxanthin supplementation than that before in both the 1 mg/d (10 subjects) and 3 mg/d (10 subjects) groups. 相似文献