共查询到20条相似文献,搜索用时 7 毫秒
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Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription 总被引:18,自引:0,他引:18
R Lafyatis R Lechleider S J Kim S Jakowlew A B Roberts M B Sporn 《The Journal of biological chemistry》1990,265(31):19128-19136
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Kingsley-Kallesen ML Kelly D Rizzino A 《The Journal of biological chemistry》1999,274(48):34020-34028
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Peng C Zhu F Wen W Yao K Li S Zykova T Liu K Li X Ma WY Bode AM Dong Z 《The Journal of biological chemistry》2012,287(31):25881-25892
TRAF2 has an important function in mediating the TNF-R signaling pathway toward activation of NF-κB and JNKs. Here we reveal a novel function of TRAF2 in the epidermal growth factor (EGF) signaling pathway. Knockdown of TRAF2 blocked EGF-induced AP-1 activity and anchorage- independent cell transformation. Notably, we showed that EGF induces ribosomal S6 kinase 2 (RSK2) ubiquitination, and knocking down TRAF2 suppresses ubiquitination of RSK2 induced by EGF. We also found that TRAF2 affects RSK2 activity through RSK2 ubiquitination. RSK2 plays a critical role in AP-1 activity mediated through CREB and c-Fos, which regulates anchorage-independent cell transformation. In addition, TRAF2 is overexpressed in colon cancer and required for colon cancer development, suggesting that TRAF2 might be a potential molecular target for cancer prevention and treatment. 相似文献
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