Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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CARM1 regulates replication fork speed and stress response by stimulating PARP1

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

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The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

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SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

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PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease

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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

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DNA-PKcs promotes fork reversal and chemoresistance

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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EMSY inhibits homologous recombination repair and the interferon response,promoting lung cancer immune evasion

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Revealing protein-protein interactions at the transcriptome scale by sequencing

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