Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

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Identification of a Structural Determinant for Selective Targeting of HDMX

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Rapid and robust optogenetic control of gene expression in Drosophila

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Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers

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Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

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Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge

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The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48

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Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40

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Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

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A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

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Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

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Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

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S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis

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Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

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Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut

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Atypical Resistance Protein RPW8/HR Triggers Oligomerization of the NLR Immune Receptor RPP7 and Autoimmunity

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Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor

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How do antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK

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