中国人血红蛋白 HbQ-Thailand 的研究

本文综合报道在中国大陆发现的十个HbQ-Thailand家系及其在中国大陆的地理分布,并对α~Q基因组织进行分析。     

Memories of The New York Botanical Garden, 1960–1980

Memories of employment at The New York Botanical Garden between 1960 and 1980 are given.     

Little of Italy? Assumed ethnicity in a New York City neighbourhood

Utilizing the case study of Albanian Kosovars employed in the restaurant business in Little Italy, New York, this paper introduces the concept of assumed ethnicity. This concept describes one ethnic group strategically presenting itself as another ethnic group, neither assimilating into mainstream society ethnicity nor validating place of origin ethnicity. Such assumed ethnicity is outwardly expressed (assumed) by the ethnic group in question, as well as accepted (assumed to be true) in both mainstream encounters and understandings of self. Applying and building on Goffman's theory of the front stage and back stage elucidates this phenomenon, where migrants instrumentally assume an ethnicity different from their own, in order to facilitate front-stage (mainstream) encounters. On the backstage, they expose their ‘true’ ethnicity, in the process drawing connections between Kosovo, Albania and Italy: ironically, authenticating assumed ethnicity by linking their front- and back-stage performances of everyday life.     

Contagion and incubation in New York City structural fires 1964–1976

The recent proliferation of structural fires in New York City is analyzed from an ecological viewpoint. Fireservice cutbacks recommended by the Rand Corporation and largely implemented before the city's fiscal crisis are found to have markedly increased the annual number of structural fires.The author thanks Drs. D. Wallace and M. Levandowski for useful discussions, and several reviewers for comments and suggestions.     

我国人异常血红蛋白的研究 Ⅳ.一例血红蛋白Stanleyville-Ⅱ的一级结构分析

Hb Stanleyville-II(α78(EF7)Asn→Lys)是一种慢速血红蛋白,已在中非等地发现多例。本文报道在广州市儿童医院住院病人中发现的一例Hb Stanleyville-II的化学结构分析结果。先证者为4个月婴儿,男,汉族,祖籍广东南海县。家系调查发现先证者的祖母和父亲均携带有相同的异常Hb。血液学检查显示所有检查对象均未因有此变异体而影响临床和血液学有不正常的改变。     

中国人血红蛋白病突变数据集和临床辅助决策管理系统

个体基因组信息得益于大数据的积累,其应用不再局限于科学研究,正在经历逐步走向日常医疗实践的过程中。对疾病关联基因组信息的系统整理、归档及合理应用配置是未来精准医学的重要基础。血红蛋白病在我国南方发病率高,其分子病理学基础有明显的种族特异性。为助力我国南方血红蛋白病的临床诊断和遗传筛查的应用,本项目团队建立了中国人群血红蛋白病变异谱及表型谱LOVD基因变异数据管理系统,并通过设计全面整合和高效分析的在线辅助精确诊断及风险评估系统,展示了基于云端标准化的特定血红蛋白病变异注释库和诊断知识库辅助医生快速做出综合、全面的诊断和遗传咨询的操作。通过数据整合和人工智能技术的结合提高疾病临床决策效率的方法和经验,可为其他疾病的临床和预防应用起示范作用。     

我国人异常血红蛋白的研究——Ⅳ.一例血红蛋白Stanleyville-Ⅱ的一级结构分析

Hb Stanleyville-Ⅱ(α78(EF7)Asn→Lys)是一种慢速血红蛋白,已在中非等地发现多例。本文报道在广州市儿童医院住院病人中发现的一例Hb Stanleyville-Ⅱ的化学结构分析结果。先证者为4个月婴儿,男,汉族,祖籍广东南海县。家系调查发现先证者的祖母和父亲均携带有相同的异常Hb。血液学检查显示所有检查对象均未因有此变异体而影响临床和血液学有不正常的改变。     

The past of others: Korean memorials in New York’s suburbia

Since the first decade of this century, public monuments to the memory of “comfort women” – women and girls forced into sexual service from the 1930s through 1945, by the Japanese Imperial Army – have been established in the United States by the Korean diaspora. This paper analyses recent memorials in the suburbs of New York that have experienced rapid immigration from Korea since the 1990s. The memorials met local resistance due to perceptions of unrelatedness to the American land. Such immigrant initiatives, however, have been supported by municipal governance. The project of inscribing a passage from East Asian history in the American context may be considered symptomatic of wider cognitive and social shifts in immigrant adaptation. Assimilation through the inclusion of immigrant heritage, along with an increasing sense of entitlement in being both “ethnic” and “American”, have been integral to this contest regarding collective memory.     

血红蛋白对人红细胞膜流动性的影响

本文报道了pH7.5时血红蛋白和红细胞膜的结合效应.在10—45℃温度范围内观察到血红蛋白对膜脂质流动性的限制作用.看来这种限制作用不是脂质过氧化所致,而是血红蛋白和红细胞膜直接作用的结果.对流动性大的膜,血红蛋白的效应也随之增大.高铁血红蛋白及红细胞膜去胆固醇皆能修饰血红蛋白和膜的相互作用.     

在猪体内高水平表达人血红蛋白

美国DNX Biotherapeutics Inc.已经报道了利用新设计的表达载体在转基因猪中高水平表达人血红蛋白。 尽管已有几个实验室报道过转基因猪,但基因转移的频率仍然很低。产生一头转基因动物的成本相当高,据DNX估计每头转基因猪将花费5万多美元。因此,用最强的基因表达来建立转基因动物已成为一个经济上的紧迫任务。     

细菌的血红蛋白研究

在人和动物体的血液中存在着大量的血红蛋白。这些蛋白质行使着向组织运输和贮存氧的功能。同样,在植物体内也有这种蛋白质,如豆血红蛋白(Leg Hb)。它的光吸收特性与动物血红蛋白的几乎完全相同,功能是为植物贮存和传递分子氧。在生物进化过程中,细     

在中国发现的异常血红蛋白的化学结构研究

1957年,Ingram首次应用“指纹图谱法”(高压电泳和层析双向分离法)测定了HbS的化学结构。二十多年来,异常血红蛋白结构分析技术不断改善,迄今世界范围内已经鉴定了化学结构的异常血红蛋白达400多种。在国内,1979年上海市儿童医院医学遗传研究室发表了血红蛋白结构分析技术,以及HbS,Hb Siriraj和HbE的化学结构分析结果。以后,又有其它异常血红蛋     

Fire service productivity and the New York City fire crisis: 1968–1979

Empirical measures of fire-service quality and efficiency are examined for New York City in the period 1968–1979. Marked decreases in the ability to control and contain structural fires are found to result from a program of fire-service reductions begun in 1972. Exacerbated by the New York City fiscal crisis of 1975, decreases in fire-service efficiency since 1972 appear to have initiated a geographically spreading and apparently recurrent fire epidemic. The decreases have accelerated since 1976, implying that recurring epidemic episodes could be more severe than the 1974–1977 crisis, which destroyed large areas in some neighborhoods of the city, including the South Bronx, Bushwick, Brownsville, East New York, East Harlem, and others. The results of an extensive data analysis are contrasted with the methods and conclusions of a widely circulated study entitled Setting Municipal Priorities 1981.     

Incorporation of 35SO 4 2− into sediments of three New York lakes

Intact sediment cores were obtained from three New York lakes in May, July, and October 1981. Radioactive S (as ³⁵SO ₄ ²⁻ ) was added to the overlying water and cores were incubated without atmospheric exchange for one week near lake bottom temperatures. Headspace flux of 0₂ as an index of sediment respiration rates varied among lakes and seasonally within lakes. Acidic South Lake had the lowest respiration rate at all seasons and also the smallest net incorporation of the ³⁵SO ₄ ²⁻ . Summer net isotope transformation into ester sulfate and non-HI reducible S (pyrite and C-bonded S) constituents was 88.6%, 89.4%, and 59.7% of total sediment isotope for Oneida, Deer, and South, respectively. Seasonal variation of net isotope incorporation was observed in each lake as were differences in ³⁵SO ₄ ²⁻ partitioning into major S pools. Of the S constituents analyzed, HCl digestible S (volatile sulfides) was the smallest pool, while ester sulfate and non-HI reducible S together accounted for greater than 50% of S isotope transformation in all lakes. In addition, ester sulfate is the major product of dissolved SO ₄ ²⁻ transformation and its formation results in less alkalinity generation than the formation of non-HI reducible S constituents. Thus ester sulfate transformation processes must be considered in calculating alkalinity generation by lake sediments. Financial support provided by Office of Water Research Technology (Project No. 13-096-NY). Financial support provided by Office of Water Research Technology (Project No. 13-096-NY).     

我国人异常血红蛋白的研究 Ⅲ.一例血红蛋白G Taipei(台北)的一级结构分析

用醋纤薄膜电泳方法检查首都医院住院病人异常血红蛋白时,在一位49岁、山西籍男性患者血液中发现一种泳动速度与HbG相同的慢速异常血红蛋白。血常规检查正常。化学结构分析结果证明该变异体是Hb G Taipei(台北),β22(B_4)谷氨酸→甘氨酸。     

Perspectives On Tuberculosis Among Traditional Chinese Medical Practitioners In New York City’s Chinatown

This article discusses the perspectives of Chinatown’s traditional Chinese medical practitioners on tuberculosis among New York City’s Chinese laborers. The practice of traditional Chinese medicine (TCM) in the United States is neither regulated nor well understood. Some public health providers have expressed their concern that the use of TCM could prevent Chinese tuberculosis patients from receiving proper, biomedical treatment. Contrary to the suspicion of public health providers, the traditional Chinese medical practitioners in the context of New York City’s Chinatown provide diverse methods of health care, many being familiar with the biomedical explanation for tuberculosis. All TCM informants in this study stated that biomedicine is more effective than Chinese medicine in treating tuberculosis. TCM in tuberculosis therapy is said to complement biomedicine and to restore bodily balance and the general health of patients. This study discusses the political–economic context shaping the explanation and treatment of tuberculosis among traditional Chinese medical practitioners and broadens our understanding of the various contexts in which TCM and biomedicine can be integrated. Furthermore, it is suggested that an opportunity exists for tuberculosis control programs to incorporate TCM practitioners in the effort to control the disease within New York City.