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1.
Background
The p49/STRAP (or SRFBP1) protein was recently identified in our laboratory as a cofactor of serum response factor that contributes to the regulation of SRF target genes in the heart. 相似文献2.
Hongyan Liu Pinxian Xi Guoqiang Xie Fengjuan Chen Zhenpeng Li Decheng Bai Zhengzhi Zeng 《Journal of biological inorganic chemistry》2011,16(8):1135-1140
Abstract
A redox luminescence switch was prepared by doping hydroxyapatite nanoparticles with CePO4:Tb. The resulting multifunctional material exhibits good biocompatibility, biological affinity, and potential drug-carrying capability. The luminescent hydroxyapatite nanoparticles may find important applications in biomedical diagnostics, drug delivery, and biological sensors. 相似文献3.
James Mallet Margarita Beltrán Walter Neukirchen Mauricio Linares 《BMC evolutionary biology》2007,7(1):28
Background
To understand speciation and the maintenance of taxa as separate entities, we need information about natural hybridization and gene flow among species. 相似文献4.
Allen D Everett Jun Yang Monzur Rahman Pratima Dulloor David L Brautigan 《BMC cell biology》2011,12(1):15
Background
Hepatoma-derived growth factor (HDGF) is a nuclear protein that is a mitogen for a wide variety of cells. Mass spectrometry based methods have identified HDGF as a phosphoprotein without validation or a functional consequence of this post-translational modification. 相似文献5.
6.
Background
Mathematical modeling of biological networks is an essential part of Systems Biology. Developing and using such models in order to understand gene regulatory networks is a major challenge. 相似文献7.
Katerina Michalickova Gary D Bader Michel Dumontier Hao Lieu Doron Betel Ruth Isserlin Christopher WV Hogue 《BMC bioinformatics》2002,3(1):32-13
Background
SeqHound has been developed as an integrated biological sequence, taxonomy, annotation and 3-D structure database system. It provides a high-performance server platform for bioinformatics research in a locally-hosted environment. 相似文献8.
Max Bylesjö Daniel Eriksson Andreas Sjödin Stefan Jansson Thomas Moritz Johan Trygg 《BMC bioinformatics》2007,8(1):207
Background
During generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to properly estimate biological effects, these biases must be identified and discarded. 相似文献9.
Objective
Observations of microcirculation reveal that the blood flow is subject to interruptions and resumptions. Accepting that blood randomly stops and resumes, one can show that the randomness could be a powerful means to match oxygen delivery with oxygen demand. 相似文献10.
First evidence of bacterial translocation from the intestinal tract as a route of Helicobacter cinaedi bacteremia
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Hideki Araoka Masaru Baba Chikako Okada Muneyoshi Kimura Tomoaki Sato Yutaka Yatomi Kyoji Moriya Akiko Yoneyama 《Helicobacter》2018,23(1)
Background
The route of Helicobacter cinaedi bacteremia has not yet been clarified. Although bacterial translocation from the intestinal tract into the circulation has been suggested, it has not been demonstrated thus far. The objective of this study was to investigate the port of entry of this bacterium.Material and Methods
We conducted a retrospective study on patients with H. cinaedi bacteremia between March 2009 and May 2013. Records of patients in whom H. cinaedi was detected in both blood and stool cultures were extracted. H. cinaedi was identified using gyrB‐targeted PCR. Pulse‐field gel electrophoresis was used to investigate the consistency of the genotypes.Results
Seventy‐one patients were diagnosed with H. cinaedi bacteremia during the study period. H. cinaedi was detected in both blood and stool samples of 21 patients. Pulse‐field gel electrophoresis was used to investigate the consistency of the genotypes in 18 evaluable strains (from 9 patients). The pulse‐field gel electrophoresis patterns of the stool‐ and blood‐derived strains of H. cinaedi were consistent among all 9 patients. Most of the 9 patients analyzed were immunocompromised and being treated with anticancer drugs or steroids, which suggests reduced intestinal immunity.Conclusions
This is the first study to demonstrate that bacterial translocation from the intestinal tract could represent one route of H. cinaedi bacteremia. 相似文献11.
Alexei A Sharov 《Biology direct》2006,1(1):17-10
Background
The size of non-redundant functional genome can be an indicator of biological complexity of living organisms. Several positive feedback mechanisms including gene cooperation and duplication with subsequent specialization may result in the exponential growth of biological complexity in macro-evolution. 相似文献12.
Background
Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. 相似文献13.
14.
Background
Occult organizational structures in DNA sequences may hold the key to understanding functional and evolutionary aspects of the DNA molecule. Such structures can also provide the means for identifying and discriminating organisms using genomic data. Species specific genomic signatures are useful in a variety of contexts such as evolutionary analysis, assembly and classification of genomic sequences from large uncultivated microbial communities and a rapid identification system in health hazard situations. 相似文献15.
Background
Multiple sequence alignments are a fundamental tool for the comparative analysis of proteins and nucleic acids. However, large data sets are no longer manageable for visualization and investigation using the traditional stacked sequence alignment representation. 相似文献16.
Carmen Di Franco Elena Beccari Tiziana Santini Giuseppe Pisaneschi Giorgio Tecce 《BMC microbiology》2002,2(1):33-15
Background
Bacillus mycoides Flügge, a Gram-positive, non-motile soil bacterium assigned to Bacillus cereus group, grows on agar as chains of cells linked end to end, forming radial filaments curving clock- or counter-clockwise (SIN or DX morphotypes). The molecular mechanism causing asymmetric curving is not known: our working hypothesis considers regulation of filamentous growth as the prerequisite for these morphotypes. 相似文献17.
Azita Monazzam Pasha Razifar Martin Simonsson Fredrik Qvarnstr?m Raymond Josephsson Carl Blomqvist Bengt L?ngstr?m Mats Bergstr?m 《Cancer cell international》2006,6(1):6
Background
In order to explore a pre-clinical method to evaluate if [18F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with five routinely used chemotherapy agents in breast cancer. 相似文献18.
Background
Metastases to the bone as the sole manifestation of recurrence of a gastric carcinoma are extremely rare. 相似文献19.
Serdar Oztora Osman Korkmaz Nezih Dagdeviren Yahya Celik Ayse Caylan Mehmet S Top Talip Asil 《BMC neurology》2011,11(1):103
Background
Migraine is a significant health problem, especially for the young people, due to its frequency and accompanying morbidity, causing disability and loss of performance. In this study, our aim was to determine the prevalence of migraine headaches among university students in Edirne, a Turkish city. 相似文献20.
Koga H Shimaya M Muneta T Nimura A Morito T Hayashi M Suzuki S Ju YJ Mochizuki T Sekiya I 《Arthritis research & therapy》2008,10(4):R84