共查询到20条相似文献,搜索用时 15 毫秒
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Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells 总被引:8,自引:0,他引:8
de Mestre AM Rao S Hornby JR Soe-Htwe T Khachigian LM Hulett MD 《The Journal of biological chemistry》2005,280(42):35136-35147
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Maliukova AV Loginov VI Khodyrev DS Kadyrova EL Pronina IV Ivanova TA Kiselev FL Zabarovskiĭ NP Braga EA 《Molekuliarnaia biologiia》2004,38(6):1005-1013
The methylation level of 13 CpG-dinucleotides in the promoter region of the putative tumor suppressor gene RASSF1A (3p21.31) was analyzed in HPV-positive squamous cell carcinomas of cervix using methyl-sensitive restriction endonuclease analysis followed by PCR. The methylation from 3 to 13 CpG-dinucleotides was observed in 64% (25/39) tumors, 22% (2/9) morphologically normal tissues adjacent to tumors (P = 0.0306) and in 2 from 3 leucocytes of peripheral blood of patients. The methylation of these CpG-dinucleotides was absent in DNA of healthy donor leucocytes (0/10). Methylation level of the examined fragment of the RASSF1A promoter region was significantly higher in tumors of patients with lymph node metastases in comparison to tumors of patients without metastases (P = 8.5 x 10(-12)). The methylation frequency of RASSF1A gene was in two times higher than hemi- and homozygous deletion frequency at the region of location of this gene (chromosome 3p21.31), determined earlier. These data suggest that methylation of the RASSF1A gene is one of the main ways of this gene inactivation in HPV-positive cervical squamous cell carcinomas. The methylation of the RASSF1A gene is an early event in genesis of tumor and the level of methylation increased with tumor progression. 相似文献
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The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. 总被引:16,自引:0,他引:16
Z Y Wang S L Madden T F Deuel F J Rauscher 《The Journal of biological chemistry》1992,267(31):21999-22002
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