The high incidence of Tinea pedis and unguium in patients with Kaposi's sarcoma

Forty patients suffering from Kaposi's sarcoma (31 males, 9 females aged from 18 to 80 years) were examined for the presence of mycotic invasion of the toe-webs, toe-nails and soles. Fungi were found without exception in all patients. In 35 patients all three sites were invaded; the remaining 5 showed no involvement of the toe-nails. The causative agent was T. rubrum in 31 patients, T. mentagrophytes in 7, E. floccosum in 2. Four subjects with T. rubrum infection also showed a super-imposed C. albicans infection in the toe-webs. The skin tests with Trichophytin and Candidin yielded a mildly positive response to the former antigen in 4 cases and to the latter in 8 cases. The strikingly high percentage of affected cases in this group of patients with Kaposi's sarcoma is discussed.

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Résumé 40 malades (31 hommes, 9 femmes, agés de 18 à 80 ans) souffrant de la maladie de Kaposi ont été examinés pour la présence d'une invasion fongique de la région plantaire, des espaces interdigitaux et des ongles des orteils. On atrouvé une atteinte mycosique chez tous, sans exception. Chez 35 tous les trois sièges examinés étaient invadés, chez 5 les ongles étaient épargnées. On a isolé le T. rubrum chez 31 malades, le T. mentagrophytes chez 7 et E. floccosum chez 2. C. albicans a été aussi trouvé comme agent de surrinfection dans les lésions interdigitales dues à T. rubrum chez 4 malades. Les testes intradermiques ont montré une faible réaction positive à la trichophytine dans 4 cas et àla Candidine dans 8 cas. Le pourcentage tellement élevé d'atteinte mycosique dans ce groupe des malades avec maladie de Kaposi est brièvement discuté.

     

Timeline of Genomics （1977-2004）

Frederick Sanger (1980 Noble Prize Laureates for Chemistry) explores the technology of DNA sequencing. Sanger and colleagues use the technique to determine the sequence of all 5,375 nucleotides of the bacteriophage phi-X174, the first completede termination of the genome of an organism.     

Changes in perceived weight discrimination among Americans, 1995-1996 through 2004-2006

Objective: Little is known about the prevalence and patterns of weight discrimination in the United States. This study examined the trends in perceived weight/height discrimination among a nationally representative sample of adults aged 35–74 years, comparing experiences of discrimination based on race, age, and gender. Methods and Procedures: Data were from the two waves of the National Survey of Midlife Developmentin the United States (MIDUS), a survey of community‐based English‐speaking adults initially in 1995–1996 and a follow‐up in 2004– 2006. Reported experiences of weight/height discrimination included a variety of settings in major lifetime events and interpersonal relationships. Results: The prevalence of weight/height discrimination increased from 7% in 1995–1996 to 12% in 2004–2006, affecting all population groups but the elderly. This growth is unlikely to be explained by changes in obesity rates. Discussion: Weight/height discrimination is highly prevalent in American society and increasing at disturbing rates. Its prevalence is relatively close to reported rates of race and age discrimination, but virtually no legal or social sanctions against weight discrimination exist.     

Subacute sclerosing panencephalitis in Croatia (1994-2004)

We studied five patients with SSPE during a 10-year period (1994-2004). The first clinical symptoms developed at the age of 5-11 years. All patients were vaccinated regularly against measles according to the official immunization schedule. One patient had measles at the age of 18 months. Two of them had a history of morbilliform rash (unrecognized measles) at the age of six and seven months, respectively. In two patients, with no history of measles before vaccination the disease started after varicella infection. Using complement-fixation (F) test and EIA, antibodies to measles virus (MV) were detected in the CSF and sera of all patients. The CF-antibody titers ranged from 1:1024 to 1:65536 in sera and from 1:16 to 1:128 in CSF samples. MV antigen was detected in brain imprints using IFA in two patients. Electron microscopic analysis revealed intranuclear viral inclusions (MV nucleocapsids). Using RT-PCR, viral RNA was found in both patients. Nucleotide sequence analysis showed that the viruses found in the brain tissue belonged to the wild-type MV D6 genotype [7].