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Regulation of picornavirus gene expression 总被引:6,自引:0,他引:6
Members of the Picornaviridae are positive- strand RNA viruses that cause a variety of human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis. Although the diseases caused by picornaviruses are diverse, the genome organization and mechanisms of gene expression are highly conserved among family members. This review will discuss the mechanisms of viral gene expression including cap-independent translation initiation, host cell translation shut off, viral polyprotein processing, and RNA replication. 相似文献
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The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related. 总被引:16,自引:2,他引:14 下载免费PDF全文
E J Snijder J A den Boon P J Bredenbeek M C Horzinek R Rijnbrand W J Spaan 《Nucleic acids research》1990,18(15):4535-4542
Sequence analysis of the 3' part (8 kb) of the polymerase gene of the torovirus prototype Berne virus (BEV) revealed that this area contains at least two open reading frames (provisionally designated ORF1a and ORF1b) which overlap by 12 nucleotides. The complete sequence of ORF1b (6873 nucleotides) was determined. Like the coronaviruses, BEV was shown to express its ORF1b by ribosomal frameshifting during translation of the genomic RNA. The predicted tertiary RNA structure (a pseudoknot) in the toro- and coronaviral frameshift-directing region is similar. Analysis of the amino acid sequence of the predicted BEV ORF1b translation product revealed homology with the ORF1b product of coronaviruses. Four conserved domains were identified: the putative polymerase domain, an area containing conserved cysteine and histidine residues, a putative helicase motif, and a domain which seems to be unique for toro- and coronaviruses. The data on the 3' part of the polymerase gene of BEV supplement previously observed similarities between toro- and coronaviruses at the level of genome organization and expression. The two virus families are more closely related to each other than to other families of positive-stranded RNA viruses. 相似文献
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Viral RNA polymerases 总被引:13,自引:0,他引:13
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De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase 总被引:1,自引:0,他引:1 下载免费PDF全文
Beerens N Selisko B Ricagno S Imbert I van der Zanden L Snijder EJ Canard B 《Journal of virology》2007,81(16):8384-8395
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RNA Transcription by the Virion Polymerases of Five Rhabdoviruses 总被引:11,自引:8,他引:3