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1.
Phytochemical composition of Hypericum genus has been investigated for many years. In the recent past, studies on the essential oils (EO) of this genus have been
progressing and many of them have reported interesting biological activities. Variations in the EO composition of Hypericum species influenced by seasonal variation, geographic distribution, phenological cycle and type of the organ in which EO are
produced and/or accumulated have also been reported. Although many reviews attributed to the characterization as well as biological
activities of H. perforatum crude extracts have been published, no review has been published on the EO composition and biological activities of Hypericum species until recently (Crockett in Nat Prod Commun 5(9):1493–1506, 2010; Bertoli et al. in Global Sci Books 5:29–47, 2011). In this article, we summarize and update information regarding the composition and biological activities of Hypericum species EO. Based on experimental work carried out in our laboratory we also mention possible biotechnology approaches envisaging
EO improvement of some species of the genus. 相似文献
2.
Extirpation of the pleurovisceral ganglia (PV) blocked egg-laying whereas reimplantation of PV or injection of a PV homogenate into PV-less animals restored the egg-laying capacity of the marine pulomonate, O. verruculatum. Injection of PV homogenate induced egg-laying in intact, mature individuals within 15–45 minutes. Boiling of the homogenate for 15 minutes did not abolish its egg-laying efficacy. However, after incubation with trypsin, a PV homogenate lost its potency. Homogenates of PV from colchicinized animals could not induce egg-laying in intact Onchidium. Similarly, colchicinized animals did not respond to a PV ectract from intact Onchidium. It is hypothesized that egg-laying in O. verruculatum is under the control of a heat-stable, trypsin sensitive hormone secreted by the PV ganglia. 相似文献
3.
Zhenbin Zhou Qiaoling Wu Qing Xie Chunyao Ling Hua Zhang Changli Sun Jianhua Ju 《化学与生物多样性》2020,17(1)
Borrelidins M?O ( 1 – 3 ), along with four previously known family members ( 4 – 7 ), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1 – 3 were elucidated by extensive spectral analyses of HR‐ESI‐MS, 1D and 2D NMR data. In addition, the cytotoxic and antibacterial activities of 1 – 7 were evaluated enabling us to propose some tentative structure‐activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7) and C(8) of the borrelidin scaffold. 相似文献
4.
Ixora is a genus of ca. 400 species in the family Rubiaceae. Since the 1940s, eighty‐one compounds including phenolics, peptides, terpenoids, and sterols have been isolated from six species of the genus Ixora. Pharmacological studies have shown that these compounds and extracts from the Ixora genus have extensive activities, such as antitumor, chemoprotective, and antioxidant activities. In this review, we summarize the phytochemical progress and list the compounds isolated from the genus Ixora. The biological activities of this genus are also covered. 相似文献
5.
A.M. Sayed N.M. Abdel-Wahab H.M. Hassan U.R. Abdelmohsen 《Journal of applied microbiology》2020,128(2):314-329
Actinomycetes are a rich source for secondary metabolites with a diverse array of biological activities. Among the various genera of actinomycetes, the genus Saccharopolyspora has long been recognized as a potential source for antibiotics and other therapeutic leads that belong to diverse classes of natural products. Members of the genus Saccharopolyspora have been widely reported from several natural sources including both terrestrial and marine environments. A plethora of this genus has been chemically investigated for the production of novel natural products with interesting pharmacological effects. Therefore, Saccharopolyspora is considered one of the pharmaceutical important genera that could provide further chemical diversity with potential lead compounds. In this review, the literature from 1976 until December 2018 was covered, providing a comprehensive survey of all natural products derived from this genus and their semi-synthetic derivatives along with their biological activities, whenever applicable. Moreover, the biological diversity of Saccharopolyspora species and their habitats were also discussed. 相似文献
6.
Hidayat Hussain Ahmed Al‐Harrasi Ghulam Abbas Najeeb Ur Rehman Fazal Mabood Ishtiaq Ahmed Muhammad Saleem Teunis van Ree Ivan R. Green Saeed Anwar Amin Badshah Afzal Shah Iftikhar Ali 《化学与生物多样性》2013,10(11):1944-1971
In this review, literature data on phytochemical and biological investigations on the genus Pluchea are compiled. Pluchea is a genus of flowering plants in the Asteraceae family and comprises ca. 80 species distributed mainly in Northern and Southern America, Africa, Asia, and Australia. Sesquiterpenoids and flavonoids are the main constituents of this genus. Compounds isolated from plants of the Pluchea genus display a variety of biological properties, viz., anticancer, antileishmanial, immunosuppressive, antioxidant, anti‐acetylcholinesterase, antimicrobial, trypanocidal, hepatoprotective, cytotoxic, larvicidal, anti‐ulcer, anti‐inflammatory, and antinociceptive activities. 相似文献
7.
This review covers structural diversity and biological activities of terpenes from soft corals of the genus of Sarcophyton, reported from 1995 to July, 2011. During this period, besides undefined species, 16 species of the genus Sarcophyton, from different geographical areas, had been chemically examined. Two hundred and five terpenes had been isolated from this genus, including eleven sesquiterpenes, 165 diterpenes, 29 biscembranoids, some of which had novel skeletons. They exhibited various biological features, such as antifeedant, anti‐inflammatory, antiviral, and antifouling activities. 相似文献
8.
Ian D. McFaruume 《Marine and Freshwater Behaviour and Physiology》2013,45(1):95-108
When uncovered by the tide, Onchidium verruculatum leaves its place of hiding, grazes on the rock surface, and thèn returns to its own home. Onchidium will follow its own mucus trail, most frequently towards the origin. This behaviour explains homing when the outward path is partly or completely retraced. Sometimes, however, homing occurs without contact with the outward trail. It was observed that trails were followed more closely at low humidities than at high humidities. No evidence was found for any method of orientation other than detection of chemical trials: when displaced onto sand Onchidium tend simply to crawl in a spiral until they contact their own trail. In addition to being a safe retreat, the home provides a fixed starting point to feeding excursions : this may facilitate re‐location of preferred feeding areas. 相似文献
9.
Jingtao He Fangyi Li Xiaohui Yan Qian Cheng Rongtao Xue Heshui Yu Zheng Li Chunhua Wang 《化学与生物多样性》2021,18(10):e2100358
Cissampelos is a significant genus comprising of approximately 21 species of the medicinal plants (Menispermaceae). The plants of this genus are used in traditional medicine for the treatment of various ailments such as asthma, arthritis, dysentery, hyperglycemia, cardiopathy, hypertension and other related problems. These plants are rich in bioactive dibenzylisoquinoline and aborphine as well as small amounts of other ingredients. In recent years, the chemical constituents and pharmacological activities of Cissampelos genus have been paid more and more attention due to their diversity. Herein, we compile the chemical constituents and biological activities on this genus, and summarize the 13C-NMR data of the main bioactive ingredients. All information comes from scientific databases such as Google Scholar, PubMed, Sci-Finder, ScienceDirect, Web of Science and CNKI. It provides valuable data for the future research and development of Cissampelos genus. 相似文献
10.
Xiao Li Ting He Xiuhuan Wang Meng Shen Xin Yan Shusheng Fan Le Wang Xiaoping Wang Xiao Xu Hong Sui Gaimei She 《化学与生物多样性》2019,16(9)
The genus Thymus (Lamiaceae) comprises about 214 species throughout the world, mainly found in North Africa, Europe, and temperate Asia zone. They are traditionally used as food additives and folk medicines. This review comprehensively summarizes information about traditional uses, chemical constituents, and biological activities of this genus and provides recommendations for future investigations. All information was gathered from scientific databases including Google Scholar, Sci‐Finder, Web of Science, ScienceDirect, and CNKI. Volatile oils are the most concerned constituents of this genus. Flavonoids, phenylpropanoids, tannins, organic acids, terpenoids, and phytosterols were also summarized. This genus plants possessed a variety of activities including antimicrobial, antioxidant, anti‐inflammatory, cytotoxic, analgesic, and antidiabetic. In brief, this review will be helpful to provide valuable data for explorations and create more interests towards Thymus genus in the future. 相似文献
11.
Xiao‐Hui Su Man‐Li Zhang Wen‐Hong Zhan Chang‐Hong Huo Qing‐Wen Shi Yu‐Cheng Gu Hiromasa Kiyota 《化学与生物多样性》2009,6(2):146-161
The plants of genus Celastrus, distributed in Asia, have been used as natural insecticides and folk medicines to treat fever, chill, joint pain, edema, rheumatoid arthritis, and bacterial infection in China for a long time. This contribution reviews the chemical constituents, 1 – 144 , isolated from the plants in genus Celastrus in the past few decades, and their biological activities. The compounds listed are sesquiterpenes (β‐agarofurans), diterpenes, triterpenes, alkaloids, and flavonoids. 相似文献
12.
Hafize Yuca Assoc. Songul Karakaya Assoc. Gülnur Ekşi Bilge Aydin Assoc. Gamze Goger Assoc. Mehmet Bona Enes Tekman Aydan Acar Şahin Prof. Oksana Sytar Prof. Nur Münevver Pinar Prof. Zuhal Guvenalp 《化学与生物多样性》2023,20(9):e202300416
Gagea genus, which is native to the Mediterranean and Black Sea regions, has attracted significant attention due to its biodiversity and potential health benefits. In this study, the biochemical composition and biological activities of methanol extracts from various parts of G. taurica were investigated, along with their anatomical and morphological characteristics. The best antimicrobial activity was found to be MeOH extracts of corm and leaf against several Candida strains with MIC=640 μg/mL. The highest level of phenolics together with significant results of antioxidant activities were observed in flowers extracts. The α-amylase inhibition assay results showed that the highest inhibition percentage was observed with acarbose (59 %), followed by leaf extract (43 %). Leaf exhibited the most effective inhibitory activity in AChE inhibition assay, whereas flower demonstrated the most significant inhibitory activity in BChE inhibition assay. Hesperidin was found as 1621.0001 ng/ml value in flower extract and 283.9339 ng/ml value leaf. 相似文献
13.
An‐Ran Wang Hong‐Chuan Song Hong‐Mei An Qian Huang Xie Luo Jin‐Yan Dong 《化学与生物多样性》2015,12(4):451-473
Chloranthus, a genus of the family Chloranthaceae, which is mainly distributed in eastern and southern Asia, has been used in Chinese folk medicine due to its antitumor, antifungal, and anti‐inflammatory activities. This review compiles the research on isolation, structure elucidation, structural diversity, and bioactivities of Chloranthus secondary metabolites reported between 2007 and 2013. The metabolites listed encompass 82 sesquiterpenoids, 50 dimeric sesquiterpenoids, 15 diterpenoids, one coumarin, and five other compounds. Among them, dimeric sesquiterpenoids, the characteristic components of plants from the genus Chloranthus, have attracted considerable attention due to their complex structures and significant biological features, e.g., antitumor, antibacterial, antifungal, anti‐inflammatory, and hepatoprotective activities, and potent and selective inhibition of the delayed rectifier (IK) K+ current and tyrosinase. 相似文献
14.
Sedef Albayrak Dr. Nazli Farajzadeh Dr. H. Yasemin yenilmez Dr. Sadin Özdemir Dr. Serpil Gonca Dr. Zehra Altuntaş Bayır 《化学与生物多样性》2023,20(7):e202300389
In this study, a new phthalonitrile derivative namely 4-[(2,4-difluorophenyl)ethynyl]phthalonitrile ( 1 ) and its metal phthalocyanines ( 2 and 3 ) were synthesized. The resultant compounds were conjugated to silver nanoparticles and characterized using transmission electron microscopy (TEM) images. The biological properties of compounds ( 1 – 3 ), their nanoconjugates ( 4 – 6 ), and silver nanoparticles ( 7 ) were examined for the first time in this study. The antioxidant activities of biological candidates ( 1 – 7 ) were studied by applying the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The highest antioxidant activity was obtained 97.47 % for 200 mg/L manganese phthalocyanine-silver nanoconjugates ( 6 ). The antimicrobial and antimicrobial photodynamic therapy (APDT) activities of biological candidates ( 1 – 7 ) were examined using a micro-dilution assay. The highest MIC value was obtained 8 mg/L for nanoconjugate 6 against E. hirae. The studied compounds and their silver nanoconjugates exhibited high APDT activities against all the studied microorganisms. The most effective APDT activities were obtained 4 mg/L for nanoconjugates ( 5 and 6 ) against L. pneumophila and E. hirae, respectively. All the studied biological candidates displayed high cell viability inhibition activities against E. coli cell growth. The biofilm inhibition activities of the tested biological candidates were also investigated against S. aureus and P. Aeruginosa. Biological candidates ( 1 – 6 ) can be considered efficient metal nanoparticle-based materials for multi-disciplinary biological applications. 相似文献
15.
Thirteen endophytic fungi were isolated from roots of three orchid species, Spathoglottis affinis, Paphiopedelum bellatulum and Phaius tankervilleae. Of these, three fungal isolates produced high levels of indole-3-acetic acid (IAA) in culture medium supplemented with 2 mg/ml
of L-tryptophan, and were selected for further analysis. Morphological characteristics and a phylogenetic analysis based on
an alignment of internal transcribed spacer regions of nuclear rDNA indicated that the fungal isolates CMU-SLP 007 and CMU-NUT
013 belonged to family Tulasnellaceae, genus Tulasnella (the anamorphic genus Epulorhiza) and the fungal isolate CMU-AU 006 belonged to Colletotrichum gloeosporioides. These three fungal isolates produced maximum levels of IAA when grown in a culture medium supplemented with 4 mg/ml of L-tryptophan
(C. gloeosporioides CMU-AU 006, 243.56 μg/ml and Tulasnella sp. CMU-SLP 007, 155.63 μg/ml) and 6 mg/ml of L-tryptophan (Tulasnella sp. CMU-NUT 013, 104.03 μg/ml). Thin layer chromatography revealed that all fungal IAA presented the same Rf value as the standard IAA. The biological activity of fungal IAA showed that it increased the length of stem forming roots
and the number of roots of kidney bean (Phaseolus vulgaris), promoted seed germination, the length of roots and root to shoot ratio of corn (Zea mays) and increased the elongation of rice (Oryza sativa) coleoptiles when compared with all controls (water and culture medium treatments). In addition, the results of all biological
activities using fungal IAA indicated that the quality of fungal IAA were similar to standard IAA. 相似文献
16.
Plants have a long history as therapeutics in the treatment of human diseases and have been used as source of medicines for ages. Searching for new biologically active natural products, many plants and herbs are screened for natural products with pharmacological activities. In this field, the genus Inula, which comprises more than 100 species, several of them being used in traditional medicine, is very important, especially due to the finding that several of the isolated pure secondary metabolites proved to possess important biological activities. Inula species have been reported as rich sources of sesquiterpene lactones, including eudesmanes, germacranes, guaianes, and dimeric structures, and since 2006 ca. 400 secondary metabolites, including more than 100 new natural products, some of them with relevant pharmacological activities, have been identified. Herein, we critically compile and update the information regarding the types of secondary metabolites found in the genus Inula and the progress in their isolation. 相似文献
17.
Jamil A. Shilpi Sanjib Saha Soon‐Lim Chong Lutfun Nahar Satyajit D. Sarker Khalijah Awang 《化学与生物多样性》2016,13(5):483-503
Chisocheton is one of the genera of the family Meliaceae and consists of ca. 53 species; the distribution of most of those are confined to the Indo‐Malay region. Species of broader geographic distribution have undergone extensive phytochemical investigations. Previous phytochemical investigations of this genus resulted in the isolation of mainly limonoids, apotirucallane, tirucallane, and dammarane triterpenes. Reported bioactivities of the isolated compounds include cytotoxic, anti‐inflammatory, antifungal, antimalarial, antimycobacterial, antifeedant, and lipid droplet inhibitory activities. Aside from chemistry and biological activities, this review also deals briefly with botany, distribution, and uses of various species of this genus. 相似文献
18.
Cheng‐Zhen Gu Sheng‐Hao Yuan Jing Lü Yi‐Jun Qiao Yuan‐Yuan Song Mohammed Esmail AbdallaElzaki Chong‐Ren Yang Ying‐Jun Zhang Ren‐Sen Zeng 《化学与生物多样性》2019,16(1)
The actinomycete genus Streptomyces is characterized by producing bioactive secondary metabolites, including antibiotics. In this study, chemical and biological investigations were carried out on Streptomyces strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline‐type macrolides, among which 4 compounds were new, namely albocyclines A–D ( 1 – 4 ). The structures of 1 – 10 were identified according to the 1D‐ and 2D‐NMR spectroscopic data. Furthermore, compounds 1 – 10 were evaluated for antimicrobial activity. Compounds 5 – 7 displayed antimicrobial activities against Candidaalbicans ATCC 90028 with the same MIC value of 10.0 mg/mL and the IC50 values of 1.5, 1.0, and 1.0 mg/mL, respectively. Thus, the research on Streptomyces sp. is of vital significance for developing new antibiotic agents. 相似文献
19.
Mohammad Ali Nisar Ahmad Haji Khan Gul Shad Ali 《Critical reviews in biotechnology》2017,37(7):833-851
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin. However, due to the limited quantities of these metabolites in wild plants, in vitro cultures were established and strategies have been adopted to enhance medicinally important secondary metabolites in these cultures. This review elaborates on the traditional medicinal uses of Artemisia species and explains current trends to establish cell cultures of A. annua and A. absinthium for enhanced production of medicinally important secondary metabolites. 相似文献
20.
Over the past decade, herbal medicine has become an item of global importance, with both medicinal and economic implications.
Thus, accurate scientific assessment has become a prerequisite for acceptance of herbal health claims. The plants of genus
Ailanthus, belong to the family Simaroubaceae, is widely used in Ayurveda and evidence-based phytotherapy. Several species of the genus
Ailanthus are widely distributed over Asia and north Australia and studied extensively over the last few decades. A compilation of
the constituents isolated from different Ailanthus species covering the literature up to December 2008 is presented in the review. The botanical classification and ethno-pharmacology
of Ailanthus plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and active
plant materials (formulations, extracts etc.), are discussed in detail. 相似文献