共查询到20条相似文献,搜索用时 105 毫秒
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Homologues of the catalase-peroxidase gene katG and the gene for the non-specific DNA binding protein dpsA were identified downstream of oxyR in Burkholderia pseudomallei. Northern experiments revealed that both katG and dpsA are co-transcribed during oxidative stress. Under conditions where the katG promoter is not highly induced, dpsA is transcribed from a second promoter located within the katG-dpsA intergenic region. A katG insertion mutant was found to be hypersensitive to various oxidants. Analysis of katG expression in the oxyR mutant indicates that OxyR is a dual function regulator that represses the expression of katG during normal growth and activates katG during exposure to oxidative stress. Both reduced and oxidized OxyR were shown to bind to the katG promoter. 相似文献
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Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells. 总被引:3,自引:0,他引:3
Reiko Udono-Fujimori Kazuhiro Takahashi Kazuhisa Takeda Kazumichi Furuyama Kiriko Kaneko Shigeru Takahashi Makoto Tamai Shigeki Shibahara 《European journal of biochemistry》2004,271(14):3076-3084
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Transcriptional regulation of the human prointerleukin 1 beta gene 总被引:15,自引:0,他引:15
M J Fenton B D Clark K L Collins A C Webb A Rich P E Auron 《Journal of immunology (Baltimore, Md. : 1950)》1987,138(11):3972-3979
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