共查询到20条相似文献,搜索用时 31 毫秒
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WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. 总被引:16,自引:0,他引:16 下载免费PDF全文
M W Mayo C Y Wang S S Drouin L V Madrid A F Marshall J C Reed B E Weissman A S Baldwin 《The EMBO journal》1999,18(14):3990-4003
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Transcriptional regulation by WT1 in development 总被引:3,自引:0,他引:3
Roberts SG 《Current opinion in genetics & development》2005,15(5):542-547
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Cyclin E is a target of WT1 transcriptional repression 总被引:5,自引:0,他引:5
Loeb DM Korz D Katsnelson M Burwell EA Friedman AD Sukumar S 《The Journal of biological chemistry》2002,277(22):19627-19632
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Xiaojun Sun Yinyin Wang Shigao Yang Fangli Ren Yongjing Xia Zhijie Chang 《Cellular signalling》2013,25(10):2039-2046
Sef (similar expression to fgf genes, also named IL-17RD) was identified as a negative regulator of fibroblast growth factor signaling. Sef-S, an alternative splice isoform of Sef, inhibits FGF-induced NIH3T3 cell proliferation. Here we report that Sef-S physically interacts with TAK1, induces Lys63-linked TAK1 polyubiquitination on lysine 209 and TAK1-mediated JNK and p38 activation. Co-overexpression of TAK1 WT, K34R, K150R, K158R mutants with Sef-S induces Lys63-linked TAK1 polyubiquitination whereas TAK1 K63R and K209R mutants fail. Furthermore, co-overexpression of Sef-S and TAK1 induce 293T cells apoptosis. These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells. 相似文献
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The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. 总被引:15,自引:0,他引:15
S B Lee K Huang R Palmer V B Truong D Herzlinger K A Kolquist J Wong C Paulding S K Yoon W Gerald J D Oliner D A Haber 《Cell》1999,98(5):663-673
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