共查询到20条相似文献,搜索用时 15 毫秒
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Rheostat control of gene expression by metabolites 总被引:6,自引:0,他引:6
Ladurner AG 《Molecular cell》2006,24(1):1-11
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Hines ER Kolek OI Jones MD Serey SH Sirjani NB Kiela PR Jurutka PW Haussler MR Collins JF Ghishan FK 《The Journal of biological chemistry》2004,279(45):46406-46414
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Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression 总被引:13,自引:0,他引:13
Benkhart EM Siedlar M Wedel A Werner T Ziegler-Heitbrock HW 《Journal of immunology (Baltimore, Md. : 1950)》2000,165(3):1612-1617
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Runx2 integrates estrogen activity in osteoblasts 总被引:6,自引:0,他引:6
McCarthy TL Chang WZ Liu Y Centrella M 《The Journal of biological chemistry》2003,278(44):43121-43129
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Many bacterial genes are controlled by metabolite sensing motifs known as riboswitches, normally located in the 5′ un-translated region of their mRNAs. Small molecular metabolites bind to the aptamer domain of riboswitches with amazing specificity, modulating gene regulation in a feedback loop as a result of induced conformational changes in the expression platform. Here, we report the results of molecular dynamics simulation studies of the S-adenosylmethionine (SAM)-II riboswitch that is involved in regulating translation in sulfur metabolic pathways in bacteria. We show that the ensemble of conformations of the unbound form of the SAM-II riboswitch is a loose pseudoknot structure that periodically visits conformations similar to the bound form, and the pseudoknot structure is only fully formed upon binding the metabolite, SAM. The rate of forming contacts in the unbound form that are similar to that in the bound form is fast. Ligand binding to SAM-II alters the curvature and base-pairing of the expression platform that could affect the interaction of the latter with the ribosome. 相似文献
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Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression 总被引:2,自引:0,他引:2
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Nakazato M Chung HK Ulianich L Grassadonia A Suzuki K Kohn LD 《Molecular and cellular biology》2000,20(22):8499-8512