共查询到20条相似文献,搜索用时 15 毫秒
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M A Tavianini T E Hayes M D Magazin C D Minth J E Dixon 《The Journal of biological chemistry》1984,259(19):11798-11803
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Structure of the promoter of the rat type II procollagen gene 总被引:11,自引:0,他引:11
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Isolation of a rat parvalbumin gene and full length cDNA 总被引:9,自引:0,他引:9
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M R el-Maghrabi A J Lange L Kümmel S J Pilkis 《The Journal of biological chemistry》1991,266(4):2115-2120
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The human cyclophilin gene was isolated from a genomic library derived from leucocyte DNA and sequenced. The gene contains five exons and four introns. The amino acid sequence deduced from the exons matches perfectly the one previously determined from the T-cell cyclophilin cDNA. A TATA box is visible in the promoter region and putative Sp1 binding sites are also found there as well as in the first intron. Six members of the middle repetitive Alu gene family are present in one or other orientation in the non-coding regions of the cyclophilin gene. Hybridisation of genomic DNA to probes derived from the promoter region or the first intron indicates that the cyclophilin gene is present as a single copy in the human haploid genome. Seven other cyclophilin-related DNA clones isolated from the same library were also characterized. They show a high degree of similarity to the cyclophilin cDNA and are colinear to it. However, multiple genetic lesions, often including deletion and/or insertion events which modify the reading frame, are found in these clones which are therefore likely to represent processed pseudogenes. 相似文献
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Structure of the human aldose reductase gene 总被引:6,自引:0,他引:6
A Graham L Brown P J Hedge A J Gammack A F Markham 《The Journal of biological chemistry》1991,266(11):6872-6877
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A Zarain-Herzberg D H MacLennan M Periasamy 《The Journal of biological chemistry》1990,265(8):4670-4677