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Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in <Emphasis Type="Italic">Drosophila melanogaster</Emphasis> and <Emphasis Type="Italic">Drosophila pseudoobscura</Emphasis> 
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下载免费PDF全文 Berman BP Pfeiffer BD Laverty TR Salzberg SL Rubin GM Eisen MB Celniker SE 《Genome biology》2004,5(9):R61
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Kobby Essien Sebastien Vigneau Sofia Apreleva Larry N Singh Marisa S Bartolomei Sridhar Hannenhalli 《Genome biology》2009,10(11):R131-15
Background
CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the beta-globin gene cluster, to imprinting of the Igf2 locus. The 11 zinc fingers of CTCF are known to differentially contribute to the CTCF-DNA interaction at different binding sites. It is possible that the differences in CTCF-DNA conformation at different binding sites underlie CTCF's functional diversity. If so, the CTCF binding sites may belong to distinct classes, each compatible with a specific functional role. 相似文献19.