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Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation
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FOG family zinc finger proteins play essential roles in development through physical interaction with GATA factors. FOG-1, like its interacting partner GATA-1, is required for normal differentiation of erythroid and megakaryocytic cells. Here, we have developed a functional assay for FOG-1 based on its ability to rescue erythroid and megakaryocytic maturation of a genetically engineered FOG-1(-/-) cell line. We demonstrate that interaction through only one of FOG-1's four GATA-binding zinc fingers is sufficient for rescue, providing evidence against a model in which FOG-1 acts to bridge multiple GATA-binding DNA elements. Importantly, we find that distinct regions of FOG-1 differentially influence erythroid versus megakaryocyte maturation. As such, we propose that FOG-1 may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell. 相似文献
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FOG acts as a repressor of red blood cell development in Xenopus 总被引:4,自引:0,他引:4
Deconinck AE Mead PE Tevosian SG Crispino JD Katz SG Zon LI Orkin SH 《Development (Cambridge, England)》2000,127(10):2031-2040
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Rylski M Welch JJ Chen YY Letting DL Diehl JA Chodosh LA Blobel GA Weiss MJ 《Molecular and cellular biology》2003,23(14):5031-5042
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GATA-1在造血干细胞的谱系分化中起关键的调控作用,为红系和巨核系发育成熟必不可少,对肥大细胞系及嗜酸性粒细胞系发育也有一定的调控作用。GATA-1的转录活性受到多层次的精确调节,其调控不同谱系分化的功能大多通过与不同的蛋白质相互作用来实施。近年来,多种新的GTAT-1相互作用蛋白质被确定,特别是GATA-1复合体的研究,揭示了GATA-1转录活性及其调控造血分化的新机制。 相似文献