共查询到20条相似文献，搜索用时 15 毫秒
1.
Background
An exciting application of genetic network is to predict phenotypic consequences for environmental cues or genetic perturbations. However, de novo prediction for quantitative phenotypes based on network topology is always a challenging task. 相似文献2.
Background
Discovering the genetic basis of common genetic diseases in the human genome represents a public health issue. However, the dimensionality of the genetic data (up to 1 million genetic markers) and its complexity make the statistical analysis a challenging task. 相似文献3.
Michelle N Knowlton Tongbin Li Yongliang Ren Brent R Bill Lynda BM Ellis Stephen C Ekker 《BMC bioinformatics》2008,9(1):7
Background
The zebrafish is a powerful model vertebrate amenable to high throughput in vivo genetic analyses. Examples include reverse genetic screens using morpholino knockdown, expression-based screening using enhancer trapping and forward genetic screening using transposon insertional mutagenesis. We have created a database to facilitate web-based distribution of data from such genetic studies. 相似文献4.
Background
The genetic epidemiology of ischemic stroke remains relatively unstudied, and information about the genetic epidemiology of ischemic stroke in populations with significant minority representation is currently unavailable. 相似文献5.
Salim Essakali Dennis Carney David Westerman Peter Gambell John F Seymour Alexander Dobrovic 《BMC biotechnology》2008,8(1):6
Background
High purity of tumour samples is a necessity for accurate genetic and expression analysis and is usually achieved by positive selection in chronic lymphocytic leukaemia (CLL). 相似文献6.
Douglas S Goodin 《BMC neurology》2010,10(1):101
Background
MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. 相似文献7.
Krishna Rao Özge Alper Kent E Opheim George Bonnet Kristine Wolfe Eileen Bryant Siobhan O'Hara Larivee Peggy Porter James K McDougall 《Cancer cell international》2006,6(1):15-11
Introduction
Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires additional genetic changes beyond immortalization and can be accomplished in vitro by accumulation of genetic changes and expression of H-ras. 相似文献8.
Background
A capable expression vector is mainly characterized by its production efficiency, stability and induction response. These features can be influenced by a variation of modifications and versatile genetic modules. 相似文献9.
10.
Background
Enormous work has shown that polyamines are involved in a variety of physiological processes, but information is scarce on the potential of modifying disease response through genetic transformation of a polyamine biosynthetic gene. 相似文献11.
Elise Jeannesson Gérard Siest Mohamed Zaiou Hind Berrahmoune Christine Masson Sophie Visvikis-Siest 《Cell biology and toxicology》2009,25(6):561-571
Background
Cell lines are widely used to monitor drug pharmacokinetics and pharmacodynamics and to investigate a number of biochemical mechanisms. However, little is known about the genetic profile of these in vitro models. 相似文献12.
Background
The ATP levels of an organism are an important physiological parameter that is affected by genetic make up, ageing, stress and disease. 相似文献13.
Radu Dobrin Jun Zhu Cliona Molony Carmen Argman Mark L Parrish Sonia Carlson Mark F Allan Daniel Pomp Eric E Schadt 《Genome biology》2009,10(5):R55-13
Background
Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues, resulting in an energy imbalance at the systems level. 相似文献14.
15.
Background
Understanding the evolutionary relationships among species based on their genetic information is one of the primary objectives in phylogenetic analysis. Reconstructing phylogenies for large data sets is still a challenging task in Bioinformatics. 相似文献16.
Genetic diversity and colony structure of Tapinoma melanocephalum on the islands and mainland of South China 
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下载免费PDF全文 Chunyan Zheng Fan Yang Ling Zeng Edward L. Vargo Yijuan Xu 《Ecology and evolution》2018,8(11):5427-5440
Aim
Tapinoma melanocephalum is listed as one of the most important invasive pest species in China. Information regarding the patterns of invasion and effects of geographic isolation on the population genetics of this species is largely lacking.Location
South China.Methods
To address this problem, we genotyped 39 colonies (two colonies were collapsed due to genetic similarity) using microsatellite markers and mitochondrial DNA sequencing to compare colony genetic structure of T. melanocephalum on the mainland and islands of South China.Results
An analysis of the colony genotypes showed that the genetic diversity of the mainland population was slightly higher than that of the island populations but not significantly so. However, the observed heterozygosity on Shangchuan Island (SCD) was significantly lower than that of the other colonies. We also found six haplotypes in 111 mitochondrial DNA COI sequences. The relatedness (r) value between colonies of SCD was 0.410, higher than that of the other populations. The genetic clusters among colonies were not related to geographic locations and exhibited admixture likely due to frequent human‐mediated dispersal associated with trade between the mainland population and the islands. Pairwise FSTs between populations showed differentiation among mainland populations, while SCD displayed high levels of divergence (FST > 0.15) from most mainland populations. There was no significant isolation by distance among colonies. Most populations showed signs of a bottleneck effect.Main conclusions
Our study suggests that there was no significant difference in the genetic diversity among the islands and the mainland; however, the lower genetic diversity, the higher degree of genetic divergence from other colonies, and the higher relatedness among nestmates made the SCD population stand out from all the others. 相似文献17.
Background
Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated with a disease. Unfortunately, many studies using these methods suffer from low reproducibility due to lack of power. 相似文献18.
Brian L Browning 《BMC bioinformatics》2008,9(1):309
Background
Large-scale genetic association studies can test hundreds of thousands of genetic markers for association with a trait. Since the genetic markers may be correlated, a Bonferroni correction is typically too stringent a correction for multiple testing. Permutation testing is a standard statistical technique for determining statistical significance when performing multiple correlated tests for genetic association. However, permutation testing for large-scale genetic association studies is computationally demanding and calls for optimized algorithms and software. PRESTO is a new software package for genetic association studies that performs fast computation of multiple-testing adjusted P-values via permutation of the trait. 相似文献19.
Background
Procedures for genetic analyses based on oligonucleotide probes are powerful tools that can allow highly parallel investigations of genetic material. Such procedures require the design of large sets of probes using application-specific design constraints. 相似文献20.