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1.
The two major modes of locomotion in humans, walking and running, may be regarded as a function of different speed (walking as slower and running as faster). Recent results using motor learning tasks in humans, as well as more direct evidence from animal models, advocate for independence in the neural control mechanisms underlying different locomotion tasks. In the current study, we investigated the possible independence of the neural mechanisms underlying human walking and running. Subjects were tested on a split-belt treadmill and adapted to walking or running on an asymmetrically driven treadmill surface. Despite the acquisition of asymmetrical movement patterns in the respective modes, the emergence of asymmetrical movement patterns in the subsequent trials was evident only within the same modes (walking after learning to walk and running after learning to run) and only partial in the opposite modes (walking after learning to run and running after learning to walk) (thus transferred only limitedly across the modes). Further, the storage of the acquired movement pattern in each mode was maintained independently of the opposite mode. Combined, these results provide indirect evidence for independence in the neural control mechanisms underlying the two locomotive modes. 相似文献
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Introduction and Method
This paper presents a corpus of sentence level eye movement parameters for unbalanced bilingual first language (L1) and second-language (L2) reading and monolingual reading of a complete novel (56 000 words). We present important sentence-level basic eye movement parameters of both bilingual and monolingual natural reading extracted from this large data corpus.Results and Conclusion
Bilingual L2 reading patterns show longer sentence reading times (20%), more fixations (21%), shorter saccades (12%) and less word skipping (4.6%), than L1 reading patterns. Regression rates are the same for L1 and L2 reading. These results could indicate, analogous to a previous simulation with the E-Z reader model in the literature, that it is primarily the speeding up of lexical access that drives both L1 and L2 reading development. Bilingual L1 reading does not differ in any major way from monolingual reading. This contrasts with predictions made by the weaker links account, which predicts a bilingual disadvantage in language processing caused by divided exposure between languages. 相似文献3.
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Hypnotic suggestions may change the perceived color of objects. Given that chromatic stimulus information is processed rapidly and automatically by the visual system, how can hypnotic suggestions affect perceived colors in a seemingly immediate fashion? We studied the mechanisms of such color alterations by measuring electroencephalography in two highly suggestible participants as they perceived briefly presented visual shapes under posthypnotic color alternation suggestions such as “all the squares are blue”. One participant consistently reported seeing the suggested colors. Her reports correlated with enhanced evoked upper beta-band activity (22 Hz) 70–120 ms after stimulus in response to the shapes mentioned in the suggestion. This effect was not observed in a control condition where the participants merely tried to simulate the effects of the suggestion on behavior. The second participant neither reported color alterations nor showed the evoked beta activity, although her subjective experience and event-related potentials were changed by the suggestions. The results indicate a preconscious mechanism that first compares early visual input with a memory representation of the suggestion and consequently triggers the color alteration process in response to the objects specified by the suggestion. Conscious color experience is not purely the result of bottom-up processing but it can be modulated, at least in some individuals, by top-down factors such as hypnotic suggestions. 相似文献
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No?mi Eggenberger Basil C. Preisig Rahel Schumacher Simone Hopfner Tim Vanbellingen Thomas Nyffeler Klemens Gutbrod Jean-Marie Annoni Stephan Bohlhalter Dario Cazzoli René M. Müri 《PloS one》2016,11(1)
Background
Co-speech gestures are omnipresent and a crucial element of human interaction by facilitating language comprehension. However, it is unclear whether gestures also support language comprehension in aphasic patients. Using visual exploration behavior analysis, the present study aimed to investigate the influence of congruence between speech and co-speech gestures on comprehension in terms of accuracy in a decision task.Method
Twenty aphasic patients and 30 healthy controls watched videos in which speech was either combined with meaningless (baseline condition), congruent, or incongruent gestures. Comprehension was assessed with a decision task, while remote eye-tracking allowed analysis of visual exploration.Results
In aphasic patients, the incongruent condition resulted in a significant decrease of accuracy, while the congruent condition led to a significant increase in accuracy compared to baseline accuracy. In the control group, the incongruent condition resulted in a decrease in accuracy, while the congruent condition did not significantly increase the accuracy. Visual exploration analysis showed that patients fixated significantly less on the face and tended to fixate more on the gesturing hands compared to controls.Conclusion
Co-speech gestures play an important role for aphasic patients as they modulate comprehension. Incongruent gestures evoke significant interference and deteriorate patients’ comprehension. In contrast, congruent gestures enhance comprehension in aphasic patients, which might be valuable for clinical and therapeutic purposes. 相似文献6.
Magdalena Krieber Katrin D. Bartl-Pokorny Florian B. Pokorny Christa Einspieler Andrea Langmann Christof K?rner Terje Falck-Ytter Peter B. Marschik 《PloS one》2016,11(1)
Over the past decades, the relation between reading skills and eye movement behavior has been well documented in English-speaking cohorts. As English and German differ substantially with regard to orthographic complexity (i.e. grapheme-phoneme correspondence), we aimed to delineate specific characteristics of how reading speed and reading comprehension interact with eye movements in typically developing German-speaking (Austrian) adolescents. Eye movements of 22 participants (14 females; mean age = 13;6 years;months) were tracked while they were performing three tasks, namely silently reading words, texts, and pseudowords. Their reading skills were determined by means of a standardized German reading speed and reading comprehension assessment (Lesegeschwindigkeits- und -verständnistest für Klassen 6−12). We found that (a) reading skills were associated with various eye movement parameters in each of the three reading tasks; (b) better reading skills were associated with an increased efficiency of eye movements, but were primarily linked to spatial reading parameters, such as the number of fixations per word, the total number of saccades and saccadic amplitudes; (c) reading speed was a more reliable predictor for eye movement parameters than reading comprehension; (d) eye movements were highly correlated across reading tasks, which indicates consistent reading performances. Contrary to findings in English-speaking cohorts, the reading skills neither consistently correlated with temporal eye movement parameters nor with the number or percentage of regressions made while performing any of the three reading tasks. These results indicate that, although reading skills are associated with eye movement patterns irrespective of language, the temporal and spatial characteristics of this association may vary with orthographic consistency. 相似文献
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Joseph A. Cacioppo Sang Wook Oh Hey-young Kim Jongki Cho Po-Ching Patrick Lin Masashi Yanagisawa CheMyong Ko 《PloS one》2014,9(4)
Endothelin-2 (EDN2), a potent vasoconstrictive peptide, is transiently produced by periovulatory follicles at the time of ovulation when corpus luteum (CL) formation begins. EDN2 induces contraction of ovarian smooth muscles ex vivo via an endothelin receptor A-mediated pathway. In this study, we aimed to determine if EDN2 is required for normal ovulation and subsequent CL formation in?vivo. In the ovaries of a mouse model that globally lacks the Edn2 gene (Edn2 knockout mouse; Edn2KO), histology showed that post-pubertal Edn2KO mice possess follicles of all developmental stages, but no corpora lutea. When exogenous gonadotropins were injected to induce super-ovulation, Edn2KO mice exhibited significantly impaired ovulation and CL formation compared to control littermates. Edn2KO ovaries that did ovulate in response to gonadotropins did not contain histologically and functionally identifiable CL. Intra-ovarian injection of EDN2 peptide results suggest partial induction of ovulation in Edn2KO mice. Endothelin receptor antagonism in wild type mice similarly disrupted ovulation, CL formation, and progesterone secretion. Overall, this study suggests that EDN2 is necessary for normal ovulation and CL formation. 相似文献
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Ana I. Fernndez Olga Viedma David G. Angeler 《International Review of Hydrobiology》2009,94(5):513-527
Nestedness analysis is a popular tool for inferring spatial species distributions, and therefore has management and conservation relevance. Ecologists frequently compute nestedness and subsequently use Spearman rank correlations for inferring relationships between the observed nested ranks of sites with biogeographic and environmental variables. Using temporary pond microcrustaceans hatched from microcosms as a case study, this paper shows that the application of this method can be problematic. While the overall degree and significance of nestedness was robust against a statistical error, the results obtained from randomly generated matrices, in which community structure from the original microcrustacean incidence matrix was maintained (fixed rows –fixed columns constraints), showed that rank correlations of observed nested patterns can be vulnerable to a Type 1 error (detecting an effect when there is none). Using expected nestedness patterns derived from rarefied original matrices to control for sample size effects did not change this result. This problem may have arisen as a result of a quantitative bias related to the disproportionate impact of rank positions of individual ponds in the analysis. Future extensive simulations studies, involving different community structures, should help identify the general reliability of rank correlation results in nestedness analyses. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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植物的物候格局通常随时间而变化,展叶、开花和结实的出现时间和数量因年而异,或因事件而异,然而,热带地区的物候格局在很大程度上仍然是未知的。该研究利用海南岛海口市海南大学校园3年的物候监测数据,分析植物的展叶、开花、结实物候格局。对物候期与环境变量进行多重回归分析影响热带地区植物物候的主要气候因子。结果表明, 热带地区植物物候格局具有明显的季节性,展叶、开花和结实分别集中在4月—6月、4月—8月、5月—11月;影响展叶和开花物候格局的气候因子均为月均日照时长,每月结实物种数与气温相关,尤其是每月果实成熟物种数与月最低气温呈显著相关。不同功能群之间物候期存在差异,灌木展叶早于草本和乔木,风媒植物展叶早于虫媒植物,肉质果型植物展叶和果实成熟时间早于非肉质果型植物。乔木开花比草本和灌木早,非肉质果型植物开花时间比肉质果型植物早,风媒植物果实成熟早于虫媒植物。这些对将来预测热带物候事件具有重要意义。 相似文献
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This paper describes a human-computer interface based on electro-oculography (EOG) that allows interaction with a computer using eye movement. The EOG registers the movement of the eye by measuring, through electrodes, the difference of potential between the cornea and the retina. A new pair of EOG glasses have been designed to improve the user''s comfort and to remove the manual procedure of placing the EOG electrodes around the user''s eye. The interface, which includes the EOG electrodes, uses a new processing algorithm that is able to detect the gaze direction and the blink of the eyes from the EOG signals. The system reliably enabled subjects to control the movement of a dot on a video screen. 相似文献
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Cristie Grazziotin Noschang Rachel Krolow Fernanda Urruth Fontella Danusa M. Arcego Luísa Amália Diehl Simone Nardin Weis Nice S. Arteni Carla Dalmaz 《Neurochemical research》2010,35(7):1083-1091
Early life events lead to behavioral and neurochemical changes in adulthood. The aim of this study is to verify the effects
of neonatal handling on spatial memory, nitric oxide (NO) production, antioxidant enzymatic activities and DNA breaks in the
hippocampus of male and female adult rats. Litters of rats were non-handled or handled (10 min/day, days 1–10 after birth).
In adulthood they were subjected to a Morris water maze or used for biochemical evaluations. Female handled rats showed impairment
in spatial learning. They also showed decreased NO production, while no effects were observed in these parameters in male
rats. No effects were observed on the number of hippocampal NADPH diaphorase positive cells. In the Comet Assay, male handled
rats showed increased DNA breaks index when compared to non-handled ones. We conclude that neonatal handling impairs learning
performance in a sex-specific manner, what may be related to NO decreased levels. 相似文献
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Roopali Yadav Brandon G. Hillman Subhash C. Gupta Pratyush Suryavanshi Jay M. Bhatt Ratnamala Pavuluri Dustin J. Stairs Shashank M. Dravid 《PloS one》2013,8(4)
Glutamate delta-1 (GluD1) receptors are expressed throughout the forebrain during development with high levels in the hippocampus during adulthood. We have recently shown that deletion of GluD1 receptor results in aberrant emotional and social behaviors such as hyperaggression and depression-like behaviors and social interaction deficits. Additionally, abnormal expression of synaptic proteins was observed in amygdala and prefrontal cortex of GluD1 knockout mice (GluD1 KO). However the role of GluD1 in learning and memory paradigms remains unknown. In the present study we evaluated GluD1 KO in learning and memory tests. In the eight-arm radial maze GluD1 KO mice committed fewer working memory errors compared to wildtype mice but had normal reference memory. Enhanced working memory in GluD1 KO was also evident by greater percent alternation in the spontaneous Y-maze test. No difference was observed in object recognition memory in the GluD1 KO mice. In the Morris water maze test GluD1 KO mice showed no difference in acquisition but had longer latency to find the platform in the reversal learning task. GluD1 KO mice showed a deficit in contextual and cue fear conditioning but had normal latent inhibition. The deficit in contextual fear conditioning was reversed by D-Cycloserine (DCS) treatment. GluD1 KO mice were also found to be more sensitive to foot-shock compared to wildtype. We further studied molecular changes in the hippocampus, where we found lower levels of GluA1, GluA2 and GluK2 subunits while a contrasting higher level of GluN2B in GluD1 KO. Additionally, we found higher postsynaptic density protein 95 (PSD95) and lower glutamate decarboxylase 67 (GAD67) expression in GluD1 KO. We propose that GluD1 is crucial for normal functioning of synapses and absence of GluD1 leads to specific abnormalities in learning and memory. These findings provide novel insights into the role of GluD1 receptors in the central nervous system. 相似文献
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microRNAs(miRNAs)是一类在转录后水平调控基因表达的不编码蛋白质的小RNA(长度20-24个碱基).其中,miR-124a是一个在哺乳动物中枢神经系统高度表达的miRNA,在神经前体细胞向神经元分化的过程中起着举足轻重的作用.由于miRNAs特异性地识别靶基因的3'端调控区(3'UTR)的靶序列,因此,在人类起源过程中基因3'UTR的单核苷酸序列变异有可能导致miRNA调控的改变.通过靶基因预测和3'UTR区在哺乳动物代表物种间的同源序列比较,我们发现miR-124a的靶基冈中有一个基因(PLOD3)3UTR的靶位点中存在人类特异突变位点.利用体外报告基因系统,发现PLOD3基因3'UTR靶位点中所含的一个人类特异的突变导致miR-124a对PLOD3的调控效率降低.研究表明,miRNAs靶基因3'UTR的序列变异具有功能效应,它有可能足人类中枢神经系统在起源和演化中发挥关键作用的重要遗传机制之一. 相似文献
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microRNAs(miRNAs)是一类在转录后水平调控基因表达的不编码蛋白质的小RNA(长度20—24个碱基)。其中,miR-124a是一个在哺乳动物中枢神经系统高度表达的miRNA,在神经前体细胞向神经元分化的过程中起着举足轻重的作用。由于miRNAs特异性地识别靶基因的3′端调控区(3′UTR)的靶序列,因此,在人类起源过程中基因3′UTR的单核苷酸序列变异有可能导致miRNA调控的改变。通过靶基因预测和3′UTR区在哺乳动物代表物种间的同源序列比较,我们发现miR-124a的靶基因中有一个基因(PLOD3)3′UTR的靶位点中存在人类特异突变位点。利用体外报告基因系统,发现PLOD3基因3′UTR靶位点中所含的一个人类特异的突变导致miR-124a对PLOD3的调控效率降低。研究表明,miRNAs靶基因3′UTR的序列变异具有功能效应,它有可能是人类中枢神经系统在起源和演化中发挥关键作用的重要遗传机制之一。 相似文献