Migration in migration-related diversity? The nexus between superdiversity and migration studies

This article argues that the notion of ‘superdiversity’ implies an investigation of diversity that goes well beyond the nature of migration origins and trajectories. To probe the academic value of superdiversity, I situate it within broader academic debates, suggesting that it is necessary to distinguish between superdiversity as a malleable social science concept – a set of variables that researchers conjunctively investigate – and superdiversity as a context in which these variables play out in complex social patterns. I argue that complexity is an integral aspect of superdiversity, before explaining how innovative research methods were used to investigate superdiversity in a dual-site project in London and Toronto in order to explore its relevance for global comparative research.     

Perverse Frictions: Pride,Dignity, and the Budapest LGBT March

Lesbian, Gay, Bisexual, and Transgender (LGBT) marches are critical and contentious events throughout post-socialist Europe: key sites of emerging sexual politics, shifting tensions between national and transnational meanings, and competing visions of citizenship. Since 1997 a ‘Pride March’, in 2008 Budapest's LGBT march was renamed the ‘Dignity March’. Taking this change as its focus, this paper explores debates within and outside Hungary's LGBT community about the meanings of ‘Pride’, ‘Dignity’, and sexuality. I argue these debates reveal competing efforts to negotiate the perilous boundaries between national and transnational discourses of identity, politics, and belonging. Situating them within Hungary's shifting political context, including recent violent attacks on the March, I suggest the move from the politics of Pride to the politics of Dignity has failed to escape the frictions of intersecting global and local discourses, instead invoking new cultural–political tensions, exclusionary boundaries, and dilemmas of identity, belonging, and politics for Hungarian LGBT people and activism.     

Introduction: race critical public scholarship

In a climate marked by expanding scholarship in ethnic and racial studies alongside sweeping changes in universities and the conditions of academic work, we seek to explore the nature of and challenges for critically engaged research, teaching and scholarship on race and racism. In particular, we look at the connection between academic scholarship and political engagement and activity that we are calling race critical public scholarship. We situate the discussion within various recent debates about universities and ‘publics’, and the public orientation and reach of academic work. We set out three frames for these issues: the impact of social movements in establishing race and racism as legitimate topics of academic investigation and setting the agenda for race research; the differing role of academics as public intellectuals and scholar-activists in addressing and engaging with publics and race issues; and the scope and limits of public sociology in addressing the responsibilities and institutionalized power of the academy. We argue that each of these frames offers a partial insight, but that further work is needed based on cases and examples that explore the facility for and challenges of undertaking race critical scholarship.     

Efficacy and Safety of Antidepressants for the Treatment of Irritable Bowel Syndrome: A Meta-Analysis

Aim

The aim of this meta-analysis was to analyze the efficacy and safety of antidepressants for the treatment of irritable bowel syndrome.

Methods

We searched MEDLINE, EMBASE, Scopus and The Cochrane Library for randomized controlled trials investigating the efficacy and safety of antidepressants in the treatment of irritable bowel syndrome. Article quality was evaluated by Jadad score. RevMan 5.0 and Stata 12.0 were used for the meta-analysis.

Results

Twelve randomized controlled trials were included in this study and most of these trials were of high quality (Jadad score ≥4). Five articles focused on tricyclic antidepressants, six articles involved selective serotonin reuptake inhibitors, and one article investigated both types of treatment. The pooled risk ratio showed antidepressant treatment can improve global symptoms (RR = 1.38, 95% CI 1.08, 1.77). In the subgroup analysis, treatment with tricyclic antidepressants showed an improvement in global symptoms (RR = 1.36, 95% CI 1.07, 1.71), while treatment with selective serotonin reuptake inhibitors showed no statistically significant difference in global symptoms compared with the control groups (RR = 1.38, 95% CI 0.83, 2.28). The pooled risk ratio of dropout due to side effects following antidepressant treatment was 1.71 with 95% CI (0.98, 2.99). The subgroup analysis showed the pooled risk ratio of dropout in the tricyclic antidepressants group was 1.92 with 95% CI (0.89, 4.17). In the selective serotonin reuptake inhibitors group, the pooled risk ratio of dropout was 1.5 with 95% CI (0.67, 3.37). Selective serotonin reuptake inhibitors showed no benefit in alleviating abdominal pain and improving quality of life. There was no difference in the incidence of common adverse events between treatment and control groups.

Conclusions

TCAs can improve global symptoms of irritable bowel syndrome, while there was no strong evidence to confirm the effectiveness of SSRIs for the treatment of IBS.     

'Like all that lives': biology,medicine and bacteria in the age of Pasteur and Koch

This essay draws a new picture of the science of bacteria in its 'golden age', circa 1880-1900: the organization of its knowledge and practice, its germ theory of disease, the difference between its two major research traditions, and, above all, its place in life science in this period that bristled with theories and debates over inheritance, variation, selection, evolution and that witnessed the transition from natural history to laboratory biology. Pasteur and Koch's science acquired this biological dimension not despite being outside academic biology, nor despite the limitations of its applied, medical matrix, but rather because of that framework. The very practices of vaccine development constituted, at the same time, a new biological model of bacterial species and variation, which aligned them with other living things. Finally, the new picture reveals unsuspected continuity to later microbiology and molecular biology. In illuminating the self-perceptions of these sciences in relation to the past, it situates and opens a critical perspective on writings by bacteriologists such as Ludwik Fleck, Fran?ois Jacob and René Dubos, which have widely informed how we understand science.     

Special Issue Editor’s choice: Global child health from birth to adolescence and beyond

Caitlin Moyer discusses PLOS Medicine’s Special Issue on Global Child and Adolescent Health.

In a new PLOS Medicine special issue, entitled “Global Child and Adolescent Health: From Birth to Adolescence and Beyond”, guest editors Zulfiqar Bhutta, Quique Bassat, and Kathryn Yount bring to the forefront new research to illuminate global challenges for achievement of child and adolescent health and survival goals, and novel ways to address these challenges. The research articles in this special issue cover a broad range of current threats to child and adolescent health and wellbeing around the globe, shining a spotlight on the health impacts of pollutions, climate change, injury, violence, infectious diseases, undernutrition, and adolescent pregnancy. It is important to identify the gaps in knowledge that stand in the way of ensuring that all children and adolescents have the opportunity to survive, grow, and achieve developmental, social, and academic milestones. These studies further this goal by investigating new strategies that may be adopted to address these areas of need.     

Connecting neuroscience and law: anticipatory discourse and the role of sociotechnical imaginaries

In recent years, attempts have increasingly been made to connect neuroscience and law. Scientists and lawyers are imagining and actively fostering the realization of futures in which neuroscience will play a prominent role in the activity of courts. In this article I take these debates as my empirical object. I trace the emergence of neurolegal discourse, explore its focus on free will and lie detection, and show how expectations about the potential role neuroscience might play in the law are being embedded in new research programs and funding streams. In so doing, I analyze the role of particular “sociotechnical imaginaries” in stimulating, directing and restricting neurolegal discourse and highlight the ways in which new visions of law, science and scientists are produced in the process. Sociotechnical imaginaries are shown to be salient in structuring anticipatory discourse, and represent a key target for social scientific intervention in such debates.     

From Neologisms to Social Practice: An Analysis of the Wanding of America

In this article I discuss how individuals and communities in the United States re–present themselves in the context of the September 11 tragedy and its complex aftermath. My aim is to explore the "American" discourse on inclusion and discrimination by examining the neologisms and social practices that were amplified by the attack in local and national debates.     

Beyond rupture: Christian culture in the Pacific

In its many forms, Christianity tends to focus adherents’ attention upon earlier religious traditions, compelling them to renew their faith, repent and seek redemption. This special issue takes up questions about Christianity’s temporal ‘secondarity’. Contributors move beyond increasingly futile theoretical debates about rupture and continuity by considering how Christians in Papua New Guinea and Solomon Islands conceptualise and enact their fraught relationships with prior religious traditions. By examining the place of culture within Christianity, contributors avoid the analytical pitfalls of assuming that Pacific culture is not already thoroughly Christian. Rather than taking up questions about initial Christian conversion, these articles focus on revival. The relentless campaigns of Christian renewal that have transformed religious landscapes more than a generation aim not only to overcome pre‐Christian powers, but also to supersede earlier versions of Christianity. In examining not only highly localised ethnotheologies, but also regional movements, this issue opens questions that should be of interest beyond the anthropology of Christianity.     

The diversity,zoogeography and geochronology of monkeys

The synoptic perspective of the fossil record of Old World monkeys presented in the preceding articles prompted the author to explore aspects of cercopithecid biology which are difficult to examine with parochial evidence. These aspects include origins and subsequent spread of monkeys through the Old World, relationship of major events in cercopithecoid history to global climatic history, zoogeography and palaeozoogeography, and comparison of palaentological and neontological versions of cercopithecid phylogenies. While there remain temporal and geographic gaps in the fossil record, difficulties in interpretations will persist, but for the cercopithecids, the fossil data base is sufficiently comprehensive to yield a view of several of the main events in their history.     

Domesticating Islam: exploring academic knowledge production on Islam and Muslims in European societies

The attacks on the Twin Towers in New York in September 2001 and subsequent events not only ignited a ‘war on terror’, but also marked a crucial change in the policies on integration of migrants of Islamic background in Europe. Most countries departed from integration policies based on some sort of recognition of cultural diversity and emphasized national culture as the only legitimate format for citizenship. The result is a strengthening of a frame of governance with the aim to regulate Islamic practices and to mould outlooks, institutional settings and legal arrangements into the nation-state format. This has been referred to as the ‘domestication of Islam’. One of the consequences is the narrowing down of research agendas and academic knowledge production. In this article I explore this process and address important fields of study that tend to be neglected in the study of Islam in Europe.     

Introduction: The Ethical Challenges of Nanotechnologies

Nanotechnologies are expected to have a substantial impact on our lives in the future. However, the nanotechnology field is characterised by many uncertainties and debates surrounding the characterisation of technologies, the nature of the applications, the potential benefits and the likely risks. Given the rapid development of nanotechnologies, it is timely to consider what, if any, novel ethical challenges are posed by developments and how best to address these given the attendant uncertainties. The three articles which comprise this symposium consider the philosophical, regulatory and risk perception and communication questions that arise from this arena.     

Biological Evolution of Replicator Systems: Towards a Quantitative Approach

The aim of this work is to study the features of a simple replicator chemical model of the relation between kinetic stability and entropy production under the action of external perturbations. We quantitatively explore the different paths leading to evolution in a toy model where two independent replicators compete for the same substrate. To do that, the same scenario described originally by Pross (J Phys Org Chem 17:312–316, 2004) is revised and new criteria to define the kinetic stability are proposed. Our results suggest that fast replicator populations are continually favored by the effects of strong stochastic environmental fluctuations capable to determine the global population, the former assumed to be the only acting evolution force. We demonstrate that the process is continually driven by strong perturbations only, and that population crashes may be useful proxies for these catastrophic environmental fluctuations. As expected, such behavior is particularly enhanced under very large scale perturbations, suggesting a likely dynamical footprint in the recovery patterns of new species after mass extinction events in the Earth’s geological past. Furthermore, the hypothesis that natural selection always favors the faster processes may give theoretical support to different studies that claim the applicability of maximum principles like the Maximum Metabolic Flux (MMF) or Maximum Entropy Productions Principle (MEPP), seen as the main goal of biological evolution.     

Articulations of Islamophobia: from the extreme to the mainstream?

This article will examine the construction and functions of, as well as relationship between, the diverse and changing articulations of Islamophobia. The aim is to contribute to debates about the definition of Islamophobia, which have tended to be contextually specific, fixed and/or polarized between racism and religious prejudice, between extreme and mainstream, state and non-state versions or undifferentiated, and offer a more nuanced framework to: (a) delineate articulations of Islamophobia as opposed to precise types and categories; (b) highlight the porosity in the discourse between extreme articulations widely condemned in the mainstream, and normalized and insidious ones, which the former tend to render more acceptable in comparison; (c) map where these intersect in response to events, historical and political conditions and new ideological forces and imperatives and (d) compare these articulations of Islamophobia in two contexts, France and the US.     

Gender and ethnicity at the millennium: from margin to centre

Three decades of feminist academic work have led to claims about its maturity and “coming of age”. This article offers a critical evaluation of feminism’s success, particularly in the context of “race” and ethnicity awareness. Feminism has challenged mainstream thought by making women and gender central concerns, by opening up new fields for study and by breaking down disciplinary barriers. However, the global hegemony of Western feminism means that the range of women’s issues tends to be narrowly and parochially conceived. Women of different ethnicities have had an uphill struggle to redefine feminist terms, benchmarks and understandings. One particular difficulty involves the use of ideas and concepts which are not easily translated into English. Drawing on debates between Western women and Islamist feminists, the article explores some of the problems in understanding terminologies and deciphering definitions about cultures and languages. It argues that the views of non-Western and ethnic minority women must be moved from margin to centre stage.     

The Icelandic genome debate

Three of the central issues in contemporary debates about the commodification of the human body are those of property, ownership, and access. This article uses the case of the central medical database on Icelanders to discuss contesting claims about the ownership of the human genome, with respect to the rapid development of biotechnology, human genome projects and DNA collections. We emphasize the contrast between commercial and communitarian perspectives and to illustrate our argument we explore debates about the Icelandic database. These debates have been intense, focusing on a range of issues, including ethics, academic freedom, public health and, last but not least, the control and ownership of medical records, genetic information and genealogical data. This article should be seen primarily as an anthropological commentary on ongoing developments.     

Whatever happened to economic anthropology?1

In the 1970s, economic anthropology, along with kinship and ecological anthropology, was regarded as a core discipline in the teaching of anthropology. The centrality of all these subjects was reflected in the debates of the time. For economic anthropology, understanding the articulation of modes of production was the problem; the holy trinity—tribe, peasant, capitalist—provided the key terms of the debate. These terms, and this problem, are history. The discipline of anthropology has been de‐cored over the past 30 years: economic anthropology, kinship and ecological anthropology are not even on the agenda in many universities today (ANU included). This presents us with a paradox because these academic trends are in inverse proportion to the importance of contemporary developments in the economy, the family and ecology as global problems facing humanity. This paradox must be addressed not by arguing for a rehabilitation of the core subjects of the 1970s—those days are long gone—but by taking a critical look at the implicit theories of value that inform anthropological thinking about the economy, the family and ecology today. I shall argue that, along with neoliberalism, ‘agency’ has been the key term of the new paradigm that emerged in the 1970s, that this paradigm is about to become history and that new ways of thinking about the economy will have to emerge as we all become victims of the ‘financialisation’ of Europe, the industrialisation of Asia and the desiccation of Australia.     

Conflicting interests in Toronto: anatomy of a controversy at the interface of academia and industry

In December 2000, the University of Toronto breached a contract it held with me, initiating a sequence of events that has led to a public letter to the University from a large number of senior figures in the psychopharmacology community, protesting against the infringement of academic freedom involved, and a first-ever legal action seeking redress for violation of academic freedom. This case has been intertwined from the start with a longer running debate about the possibility that the SSRI group of antidepressants may have the potential to trigger suicidality or other serious effects in a subgroup of takers. And this specific issue connects to concerns about conflict of interest in the domain of therapeutics, as well as in science in general, the ghostwriting of scientific articles, and a series of other hot-spots on the interface between academia and industry.     

Introduction to "Landscapes over Time"

There is a growing recognition that modern environmental problems bear striking resemblance to those faced by past societies and that to understand the environmental present we must consider the total sweep of anthropogenic environmental change on specific landscapes. This "In Focus" assembles five articles encompassing diverse time periods and different global regions to make the case that long-term perspectives on the relationship between people and their environmental contexts are critical for understanding and evaluating contemporary environmental debates, interpretations, and even policies.     

ALES: cell lineage analysis and mapping of developmental events

MOTIVATION: Animals build their bodies by altering the fates of cells. The way in which they do so is reflected in the topology of cell lineages and the fates of terminal cells. Cell lineages should, therefore, contain information about the molecular events that determined them. Here we introduce new tools for visualizing, manipulating, and extracting the information contained in cell lineages. Our tools enable us to analyze very large cell lineages, where previously analyses have only been carried out on cell lineages no larger than a few dozen cells. RESULTS: Ales (A Lineage Evaluation System) allows the display, evaluation and comparison of cell lineages with the aim of identifying molecular and cellular events underlying development. Ales introduces a series of algorithms that locate putative developmental events. The distribution of these predicted events can then be compared to gene expression patterns or other cellular characteristics. In addition, artificial lineages can be generated, or existing lineages modified, according to a range of models, in order to test hypotheses about lineage evolution. AVAILABILITY: The program can run on any operating system with a compliant Java 2 environment. Ales is free for academic use and can be downloaded from http://mbi.dkfz-heidelberg.de/mbi/research/cellsim/ales.