Mistrust,fragmented solidarity,and transnational migration: Colombians in New York City and Los Angeles

This article compares the transnational economic, political, and sociocultural relations of Colombian migrants residing in two different locations in the United States. The vast majority of these migrants are middle class and originally from large urban areas, which differs from the typical rural-origin migrants previously studied by transnational scholars. The analysis is based on theoretical developments from transnational studies and insights advanced by economic sociology. Our findings suggest that transnational relations and activities do not follow a linear path and are not necessarily and inevitably a progressive process. The reach, scope and effects of transnational activities are contingent on the interaction of multiple contextual (state of origin-migrants relations; state of origin relations with country of destination; context of reception of immigrants abroad) and group factors (size, class composition, mode of settlement).     

Transnational migration and the redefinition of the state: Variations and explanations

In this article, we examine the shifting policies of sending country states towards communities living abroad, demonstrate the ways in which these are redefining the relationship between the state and its territorial boundaries, and highlight how these reconfigure conventional understandings of sovereignty, citizenship and membership. We begin by delineating the ­different types of policies that sending states are adapting in order to break down categories like "global nations policies" and to identify similarities and differences between states. We then suggest some possible explanations both for the convergence we see on the "repertoire" of policies that states employ and divergence we see in how far states are willing to go to ensure that migrants remain enduring long-distance membership. We draw on material from several countries, but look most closely at Brazil, Mexico, the Dominican Republic and Haiti.     

Transnational dynamics in researching migrants: self-reflexivity and boundary-drawing in fieldwork

Abstract

This article links migrant transnationalism with methodological debates, in particular the researcher's positionalities and self-reflexivity, which have so far barely been addressed in transnational studies in any systematic manner. Drawing upon my fieldwork experience in a German city, ‘Schönberg’, it examines the process of boundary-drawing and re-drawing between the research participants and the researcher. While there is undeniably a clear power hierarchy between the two parties that originates in national belonging, other positionalities such as gender, ethnicity, class and stage in the life cycle may, at their intersection, work to reverse such an asymmetrical relationship. Boundaries between ‘us’ and ‘them’ are not static and are, rather, created in a situational manner. Thus, attending to multiple positionalities in their intersection in research processes may help the researcher to re-evaluate the naturalized primacy given to national belonging.     

Transnational cyberpublics: new political spaces for labour migrants in Asia

This article offers a cultural interpretation of transnational solidarities that Asian political activists are generating through electronic telecommunications networks. Its focus is on the experiences of the Migrant Forum in Asia [MFA], a network of non-government organizations that question issues of human rights, citizenship and working conditions of labour migrants in the Asian region. MFA's networking activities are being transformed as email enables daily conversations across multiple national borders, and new 'imagined' communities of political action have emerged. English has been chosen as the language of solidarity, and photographs have become important in communicating activities and ideas. These media are innovative modes of transnational communication and shape political spaces that exist in symbiotic relation to the 'real'. Attention to these practices, spaces and the symbolic meanings activists attach to these communities helps to illuminate a cultural politics of transnational activism in this region.     

'India Shopping': Indian Grocery Stores and Transnational Configurations of Belonging

The cost of health services within the USA has increased in recent years, limiting access for many Americans. In response, a growing number of Americans are traveling to medical border towns in Mexico to meet their needs. However, many US patients feel uncomfortable traveling to Mexico for healthcare because they are unsure how the system works and believe that Mexico is dangerous, unregulated, unsanitary, and premodern. To reconcile these beliefs with the need for quality medical care, Mexican medical providers appropriate aspects of the US medical system to encourage patronage and alleviate the concerns of patients. This paper examines how some Mexican dentists, pharmacists and physicians in the Mexican border town of Nuevo Progreso have broadened their appeal to American patients by (a) associating their procedures with US biomedical standards, (b) building facilities that shadow US counterparts, and (c) facilitating access to the Mexican medical system.     

Obstetric violence as immigration injustice: A view from the United States and Colombia

In September 2020, Project South, along with numerous other organizations, released a report detailing abuses in a Georgia Detention Center – including forced hysterectomies. Whatever other factors are at play, one of them is an intrinsic connection between obstetric violence against pregnant migrants and immigration injustice. It is not incidental that these acts – in US detention centers, along the US-Mexico border, in Colombian hospitals and clinics – are being perpetrated on immigrant bodies. And it is not accidental or random which immigrant bodies are vulnerable to these violations. Understanding and confronting obstetric violence directed at pregnant migrants, though, requires reconceptualizing the nature of obstetric violence itself. In particular, we must recognize that obstetric violence against pregnant Latin American migrants in the United States and Colombia is a type of immigration injustice, a means to perpetrate immigration injustice, and a product of immigration injustice. As such, bioethicists need to collaborate with immigration scholars to resist it. After providing some background on the nature of obstetric violence and some ways it is perpetuated against pregnant migrants in the United States and Colombia, I will give a brief overview of how I conceptualize immigration justice. From there, I explain how this type of obstetric violence constitutes a type of immigration injustice, a means to perpetrate immigration injustice, and a product of immigration injustice. My hope is that this analysis motivates bioethicists throughout the Americas to engage with immigration scholars and activists to confront the issue more forcefully.     

Transnational drifters or hyperspace dwellers: an exploration of the lives of Filipino seafarers aboard and ashore

This article considers seafarers as transnational actors in the global economy. It is based on research undertaken as part of an ESRC/Seafarers International Research Centre [SIRC] funded project. The study utilized on-board participant observation and depth interviews to explore the lives of seafarers sailing on ships with multinational crews. In addition depth interviews were conducted with seafarers who have settled in port cities such as Rotterdam and Hamburg. Here the article investigates the extent to which such seafarers are embedded in their 'host' societies and examines the links they maintain with their 'homes' by exploring their networks, social relationships, patterns of communication, remittance habits, and investment strategies.     

An idea of community and its discontents: towards a more reflexive sense of belonging in multicultural Britain

In many less developed countries economic development is not in conformity with the actual level of consumption. In part this is to be explained by the huge informal sector that is not included in official statistics. However, using Suriname as a case study, it is argued in this article that a significant part of the discrepancies can be explained from private household transfers from The Netherlands. Migration is not a loss in all respects, but sometimes an asset. In contrast the remittances from temporarily migrated workers, the transfers from people constituting a transnational community cannot be taken for granted. This private family aid expresses personal commitments at the primordial level, and is therefore a kind of moral capital. Depending on the size of the migrated community and the moral commitments of their members, these transfers constitute a net surplus from the former metropolis to the periphery.     

Discovery of veterinary antiparasitic agents in the 21st Century: A view from industry

Discovery of antiparasitic agents is a challenging process, requiring discovery of molecules with the ability to kill parasites but not their hosts. Customer preference is for fewer doses and ease of application, but this is not always compatible with reduced withdrawal times, human food safety and/or user safety. This article describes some of the difficulties faced by researchers in the search for new antiparasitic agents, while highlighting advances that may improve the discovery process and the chance of success in discovering novel drugs.     

Signaling from endosomes: location makes a difference

In all transmembrane receptor systems the kinetics of receptor trafficking upon ligand stimulation is maintained in a balance between degradative and recycling pathways in order to keep homeostasis and to strictly control receptor-mediated signaling. Endocytosis is commonly considered as an efficient mechanism of uptake and transport of membrane-associated signaling molecules leading to attenuation of ligand-induced responses. Accumulating evidence, however, shows that signaling from internalized receptors not only continues in endosomal compartments, but that there are also distinct signaling events that require endocytosis. Endocytic organelles form a dynamic network of subcellular compartments, which actively control the timing, amplitude, and specificity of signaling. In this review we provide examples in which signal transduction either requires an active endocytic machinery, or directly originates from various types of endosomes. Based on recent discoveries, we emphasize the close interdependence between signaling and endocytosis, and the physiological relevance of endocytic transport in health and disease.     

Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine

Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. Although it is a highly competitive cell-penetrating peptide (CPP), its relatively large size of 33 amino acids and the presence of three internal disulfide bridges may hamper its development for in vitro and in vivo applications. Here, we demonstrate that several efficient CPPs can be derived from maurocalcine by replacing Cys residues by isosteric 2-aminobutyric acid residues and sequence truncation down to peptides of up to 9 residues in length. A surprising finding is that all of the truncated maurocalcine analogues possessed cell penetration properties, indicating that the maurocalcine is a highly specialized CPP. Careful examination of the cell penetration properties of the truncated analogues indicates that several maurocalcine-derived peptides should be of great interest for cell delivery applications where peptide size matters.     

Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif

Proprotein convertase 7 (PC7) is a member of the subtilisin-like proprotein convertase family, which is involved in the endoproteolysis of a variety of precursor proteins. Under steady state conditions, PC7 is mainly localized in the trans-Golgi network, but a small fraction is found at the cell surface. So far, no sorting signals for membrane trafficking have been identified in PC7. In this study, we have examined the internalization of PC7 from the plasma membrane. Our results show that internalization of PC7 is mediated by clathrin-coated vesicles. After inhibition of clathrin-mediated endocytosis using hypertonic conditions or the small molecule inhibitor, Pitstop 2, PC7 accumulated at the plasma membrane. Furthermore, PC7 was present in isolated clathrin-coated vesicles. To determine the internalization motif, constructs were generated in which parts of the N and C terminus of the cytoplasmic tail of PC7 were deleted, and chimeric proteins were constructed consisting of the luminal and transmembrane domains of Tac (CD25) and parts of the cytoplasmic domain of PC7. Antibody uptake experiments as well as surface biotinylation experiments demonstrated that the region between Ala(713) and Cys(726) in the cytoplasmic domain of PC7 is essential and sufficient for the internalization of PC7 but not for trans-Golgi network localization. Individual amino acids in this region were substituted with alanine, which identified Pro, Leu, and Cys as the essential amino acids. In conclusion, internalization of PC7 depends on a short transferable sequence in the cytoplasmic tail, which contains the three crucial amino acids PLC.     

Hmong infrapolitics: a view from Vietnam

Drawing upon notions of indigenization of modernity, agency and resistance in the context of an egalitarian society – the Hmong in northern Vietnam – I explore whether agency that is directed at diverting modernization is automatically intentional and patent, whether under certain circumstances it becomes resistance, and whether it is necessarily a project. I suggest the Hmong in Vietnam use infrapolitics while being tactically selective about modernity. I note that agency and the power to act appear and evolve in context and must be studied in relation to the specific circumstances that have formed the acting subjects. My argument relates to Sahlins’ proposition that ‘Local societies everywhere have attempted to organise the irresistible forces of Western World system by something even more inclusive – their own system of the world, their own culture.’     

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma

Melanocytes uniquely express specialized genes required for pigment formation, some of which are maintained following their transformation to melanoma. Here we exploit this property to selectively target melanoma with an antibody drug conjugate (ADC) specific to PMEL17, the product of the SILV pigment-forming gene. We describe new PMEL17 antibodies that detect the endogenous protein. These antibodies help define the secretory fate of PMEL17 and demonstrate its utility as an ADC target. Although newly synthesized PMEL17 is ultimately routed to the melanosome, we find substantial amounts accessible to our antibodies at the cell surface that undergo internalization and routing to a LAMP1-enriched, lysosome-related organelle. Accordingly, an ADC reactive with PMEL17 exhibits target-dependent tumor cell killing in vitro and in vivo.     

Transnational migrations in an anthropo-demographic view: A bridge between qualitative and quantitative approaches

The present study focuses on transnational migrations from Morocco and Tunisia to the city of Parma (Emilia-Romagna, Northern Italy) between 1989 and 2000. The main goal is to link the analytical depth of qualitative investigations (basically based on retrospective biographical narration) to the synthetic power of quantitative sociodemographic analyses, able to describe the characteristics of immigrations in a given area. The focus is on the evaluation of the role that migrations have in the life-course of individuals and communities and the anthropological demography provides us an integrated approach of micro and macro levels, magnifying the potentialities of the single components and methodologies. On the one hand, the annual surveys of Parma's Registry Office (1989/2000) allowed us to observe the migrant population during the decade. From 1989 to 2000, 9754 foreigners acquire their residence in the municipality: 20% are Tunisians (1276 people, of which 1068 men and 208 women) and about 9% are Moroccans (652 people, of which 451 men and 201 women). On the other hand, 34 life-histories of people from Morocco and Tunisia (18 males and 16 females) describe the native family, the individual life-courses (nuptial and procreative history) of other family members as well as the personal narration of one's own migratory experience. Such histories stand out as significant evidences of the many possible migratory trajectories of Moroccan and Tunisian native. The complexity of family migratory dynamics is therefore investigated, even determining its evolution throughout the last decade. We wish to thank the Fyssen Foundation, thanks to which the post doctoral studies of Dott.ssa Pellegrino are carried out.