Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

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TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages

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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

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Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1

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Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain

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Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

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Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28

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RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

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Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

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Regulation of Multiple Fission and Cell-Cycle-Dependent Gene Expression by CDKA1 and the Rb-E2F Pathway in Chlamydomonas

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