RAD51 protects human cells from transcription-replication conflicts

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DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts

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Coevolving Plasmids Drive Gene Flow and Genome Plasticity in Host-Associated Intracellular Bacteria

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GCNA Preserves Genome Integrity and Fertility Across Species

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SALL4 controls cell fate in response to DNA base composition

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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

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Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited

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Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation

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Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

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CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis

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De novo mutation hotspots in homologous protein domains identify function-altering mutations in neurodevelopmental disorders

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Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease

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Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes

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Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases

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Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition

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Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA50/ATX-FGF14

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Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions

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Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

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