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Xingbo Xu Xiaoying Tan Bj?rn Tampe Elisa Sanchez Michael Zeisberg Elisabeth M. Zeisberg 《The Journal of biological chemistry》2015,290(27):16653-16664
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Shu-jen Chen Nicholas E. Hoffman Santhanam Shanmughapriya Lei Bao Kerry Keefer Kathleen Conrad Salim Merali Yoshinori Takahashi Thomas Abraham Iwona Hirschler-Laszkiewicz JuFang Wang Xue-Qian Zhang Jianliang Song Carlos Barrero Yuguang Shi Yuka Imamura Kawasawa Michael Bayerl Tianyu Sun Mustafa Barbour Hong-Gang Wang Muniswamy Madesh Joseph Y. Cheung Barbara A. Miller 《The Journal of biological chemistry》2014,289(52):36284-36302
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Takashi Okabe Megumi Kumagai Yoshihiro Nakajima Suguru Shirotake Kiichiro Kodaira Masafumi Oyama Munehisa Ueno Masaaki Ikeda 《PloS one》2014,9(10)
In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among these genes, Per2 is reported to have tumor suppressor properties, but little is known about the correlation between Per2 and HIF, which is the main target of renal cell carcinoma (RCC) therapy. In this study, the rhythmic expression of the Per2 gene was not detectable in renal cancer cell lines, with the exception of Caki-2 cells. In Caki-2 cells, HIF1α increased the amplitude of Per2 oscillation by directly binding to the HIF-binding site located on the Per2 promoter. These results indicate that HIF1α may enhance the amplitude of the Per2 circadian rhythm. 相似文献
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Florinda Meléndez-Rodríguez Andrés A. Urrutia Doriane Lorendeau Gianmarco Rinaldi Olga Roche Nuray Böğürcü-Seidel Marta Ortega Muelas Claudia Mesa-Ciller Guillermo Turiel Antonio Bouthelier Pablo Hernansanz-Agustín Ainara Elorza Elia Escasany Qilong Oscar Yang Li Mar Torres-Capelli Daniel Tello Esther Fuertes Enrique Fraga Julián Aragonés 《Cell reports》2019,26(9):2257-2265.e4
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