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垂体前叶内神经纤维可能参与ACTH分泌的调节 总被引:3,自引:0,他引:3
我们建立了垂体组织块短时温育并施加电场刺激的离体实验体系,运用此方法并结合放射免疫测定激素含量,观察了大鼠垂体前叶内神经纤维对促肾上腺皮质激素(ACTH)释放的影响。结果表明,电场刺激能够促使垂体前叶ACTH释放显著增加,刺激参数为强度30mA,波宽0.5ms,频率10Hz。这个效应可为温育液中加入河豚毒素(TTX)和藜芦碱所阻断,但TTX不能阻断精氨酸加压素(AVP)诱发的ACTH分泌。同样参数的电场刺激对分散培养的大鼠垂体前叶细胞ACTH的分泌没有显著作用。以上结果说明,我们所用参数的电场刺激产生的效应是兴奋了垂体前叶内的神经纤维,而非直接刺激腺细胞所致。上述结果提示:垂体前叶激素分泌的调节除了传统的体液途径之外,还可能存在直接的神经控制。 相似文献
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Abstract— Isolated bovine central nerve myelin sheath preparations showed non-specific esterase activity towards naphthyl ester substrates of increasing chain length from acetate to palmitate. Short chain esters were hydrolysed much faster than long chain substrates by myelin, the specific activity for the hydrolysis of β-naphthyl acetate being the highest. Micro-somal fractions from brain white matter were much higher in esterase activity to all naphthyl ester substrates. NADPH-cytochrome c reductase activity was absent from isolated myelin samples. Distilled water and salt and buffer solutions of different ionic strengths and pH were ineffective in releasing non-specific esterase activity from myelin although tri-potassium citrate caused marked inhibition of the membrane-bound esterase activity. The detergent Triton X-100 released esterase activity from the myelin preparations but at a concentration of 0.1 per cent was also inhibitory. 相似文献
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Carl E. Nemethi 《The Western journal of medicine》1956,84(1):35-38
Loss of sensation in a finger due to industrial injury is of rather high incidence as a cause of disability. In many cases “finger blindness” can be prevented by nerve repair immediately after injury. Over a period of three years at a clinic for treatment of industrial injuries, primary nerve repair resulted in 95 per cent of cases in usefully functioning digits. 相似文献
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THE ROLE OF NERVE GROWTH FACTOR IN THE RAMIFICATION OF SYMPATHETIC NERVE FIBRES INTO THE RAT IRIS IN ORGAN CULTURE 总被引:4,自引:0,他引:4
D. G. Johnson S. D. Silberstein I. Hanbauer I. J. Kopin 《Journal of neurochemistry》1972,19(9):2025-2029
Small amounts of nerve growth factor (NGF) were present in the superior cervical ganglion and the iris of the rat. The observations that NGF content in each of the tissues was depleted during organ culture and that more NGF appeared in the media than was originally present in the tissues indicated that synthesis or activation of NGF had occurred in organ culture. Antibody to NGF or the depletion of endogenous NGF retarded growth of new sympathetic axons into irides in organ culture. Exogenously added NGF appeared to enhance the initiation of axonal sprouting and the rate of the ramification of nerve fibres. 相似文献
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N. Meadoff 《The Western journal of medicine》1949,70(4):252-256
Injuries of the median nerve in fractures in the region of the wrist are not uncommon.Median nerve palsy is frequently the result of immobilizing the wrist in acute palmar flexion.Good reduction and immobilization of the wrist in neutral position are the best means of preventing median nerve injury.In any fracture in the region of the wrist, the status of the median, ulnar, and radial nerves should be examined before and after reduction of the fracture.The majority of patients with median nerve neuritis recover completely without operation. In some cases, the duration of the sympathetic nerve paralysis is unpredictable.Where neurological symptoms persist, neurolysis with or without sectioning of the transverse carpal ligament will improve the neurological status of the patient. 相似文献
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在麻醉猫和麻痹的切断迷走神经的清醒猫,观察了膈神经单纤维电活动特征。1.电活动类型:按膈神经单纤维放电与其总干放电的相位关系分为三种类型。(1)完全同步型,即单纤维放电与总干放电同时开始并同时停止,占76.9%。(2)部分同步型占15.4%,其中早期同步,即单纤维放电与总干放电同时开始,但提前终止,占1.9%,中期同步,即单纤维放电较总干放电开始晚,又提前终止,占5.8%,晚期同步,即单纤维放电较总干放电开始晚,但两者同时终止,占7.7%。(8)非同步型,即吸气相和呼气相都有放电,但呼气相时冲动频率较低,占7.7%。前两型为单纯的吸气性放电,共占92.3%。2.单纤维放电平均参数值:麻醉猫每次吸气发放11个冲动,其频率为21次/秒,清醒猫每次吸气发放18个冲动,其频率为34次/秒。结果表明:猫膈神经单纤维放电类型和文献上报导的直接记录膈神经运动神经元放电一致,即以单纯的吸气性放电为最多。 相似文献
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John H. Northrop 《The Journal of general physiology》1931,15(1):29-43
A protein fraction has been isolated from crude pepsin preparations which is about 400 times as active as crystalline pepsin in the lique-faction of gelatin. The activity as measured by the digestion of casein, edestin or egg albumin is less than that of crystalline pepsin. It is more resistant to alkali than the crystalline pepsin. 相似文献
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John Kuo 《American journal of botany》1983,70(2):159-164
The nacreous walls of sieve elements occur in seagrasses in all three genera of the family Zosteraceae and the genus Halodule of the family Cymodoceaceae but are absent from another eight seagrass genera belonging to the families Hydrocharitaceae, Cymodoceaceae, and Posidoniaceae. They occur in leaf blades, leaf sheaths, rhizomes, and erect stems but are not present in root tissues. The nacreous wall is uneven along the inner limits reflecting irregular thickness. The wall consists of hemicellulose or pectin and cellulose, but no protein, lignin, or lipid. Ultrastructurally, the wall contains parallel microfibrils or loose fibrils embedded in an amorphous matrix. Open pores occur in sieve plates and branching plasmodesmata are present in enlarged sieve areas. Mitochondria, endoplasmic reticulum, and plastids are also present in these sieve elements. 相似文献
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