Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

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Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED

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Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells

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Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration

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Lyso-PAF,a biologically inactive phospholipid,contributes to RAF1 activation

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Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

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Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets

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Follicular regulatory T cells produce neuritin to regulate B cells

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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state

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HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

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Transmembrane dimers of type 1 receptors sample alternate configurations: MD simulations using coarse grain Martini 3 versus AlphaFold2 Multimer

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Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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Human CEACAM1 N-domain dimerization is independent from glycan modifications

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Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase

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Global,distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans

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