Melatonin: A hormone that modulates pain

AimsMelatonin is a hormone synthesized principally in the pineal gland that has been classically associated with endocrine actions. However, several lines of evidence suggest that melatonin plays a role in pain modulation. This paper reviews the available evidence on melatonin's analgesic effects in animals and human beings.Main methodsA medline search was performed using the terms “melatonin”, “inflammatory pain”, “neuropathic pain”, “functional pain”, “rats”, “mice”, “human”, “receptors”, “opioid” and “free radicals” in combinations.Key findingsThe antinociceptive effect of melatonin has been evaluated in diverse pain models, and several findings show that melatonin receptors modulate pain mechanisms as activation induces an antinociceptive effect at spinal and supraspinal levels under conditions of acute and inflammatory pain. More recently, melatonin induced-antinociception has been extended to neuropathic pain states. This effect agrees with the localization of melatonin receptors in thalamus, hypothalamus, dorsal horn of the spinal cord, spinal trigeminal tract, and trigeminal nucleus. The effects of melatonin result from activation of MT₁ and MT₂ melatonin receptors, which leads to reduced cyclic AMP formation and reduced nociception. In addition, melatonin is able to activate opioid receptors indirectly, to open several K⁺ channels and to inhibit expression of 5-lipoxygenase and cyclooxygenase 2. This hormone also inhibits the production of pro-inflammatory cytokines, modulates GABA_A receptor function and acts as a free radical scavenger.SignificanceMelatonin receptors constitute attractive targets for developing analgesic drugs, and their activation may prove to be a useful strategy to generate analgesics with a novel mechanism of action.     

Visual processing of pictures

Word responses have been used to dedde whether pictures of expressive faces or postures portray truthful expressions. Previous investigators have assumed words are used only as symbols of “meaning”. They did not appreciate the use of words as symbols of “sorting”. If one viewer calls two photographs “angry” and another viewer calls the same two photographs “happy,” the viewers may disagree in their “meanings” but they agree in their ‘sortings” both agree each photograph portrays the same expression. Sorting groups reveal how the visual system processes photographic images.     

Animal Adoption as Negotiated Order: A Comparison of Open Versus Traditional Shelter Approaches

ABSTRACT

Recently, the sheltering community has begun to reevaluate its adoption policies and the attitudes that shelter workers have towards adopters. Some shelters are now implementing what have been termed “open” adoptions as a way of increasing the number of animals adopted into good homes, moving away from more “traditional,” protective approaches. Based on in-depth interviews with, and observation of, the staff at two such shelters, this study examines how the adoption process is a negotiated order; namely, that workers in concert with each other and potential adopters figure out on a case-by-case basis how to interpret and implement formal adoption policies. Workers at both shelters similarly sorted potential adopters into various categories but relied on different strategies for influencing the outcome of the adoption process.     

Dynamique et èvolution de l'herbier à Posidonia oceanica en Méditerranée

Abstract

The natural growth of a Posidonia oceanica meadow is the result of a long process of development (series of events), but the dynamics are often difficult to establish because of the lack of a zero state and of sufficiently long chronological series. In addition, while it is sometimes possible to observe major regressions, the phenomena of recolonisation and of small-scale fluctuations are rarely detected. Nevertheless, with the emergence of new investigatory techniques (lepidochronology, microcartography, monitoring networks, accurate dating techniques, etc.,) considerable progress has been made in this field. The development in space and time of the seagrass beds is dependant on hydrodynamic action and sedimentary deposits. This means that in sheltered bays Posidonia oceanica may form original structures such as barrier reefs or micro-atolls, while in turbulent waters one observes the formation of spectacular structures resulting from erosion (intermatte, “rivière de retour”). A disequilibrium in sedimentation may result in dramatic regression in some seagrass beds. The multiplicity of prevailing environmental conditions results in the occurrence of a range of meadow types: “herbiers de plaines”, “herbiers de collines”, “herbiers tigrés”, “herbiers en escalier”. The impact of human pressure over the past few decades has not been insignificant. Coastal development constructions that have altered the direction of currents and the sedimentation, sewage outfalls that have resulted in an increase in the turbidity of the water and the mechanical action of anchors or trawl nets which have damaged certain areas of seagrass meadow have caused extensive regression. Conversely, the rehabilitation of previously degraded areas has made it possible to monitor the process of recolonisation.     

Organization and Control of Microtubule Pattern in Centrohelidan Heliozoa*†

SYNOPSIS. Comparative studies of axopodial microtubule pattern in 10 different centrohelidan Heliozoa belonging to the genera Acanthocystis, Raphidiophrys and Heterophrys suggest that 2 basic principles govern pattern formation in centrohelidan Heliozoa. While the larger “open” arrays with unspecified number of microtubules, e.g. in A. aculeata and R. ambigua, may result from self-linkage of additional microtubules around centroplast-nucleated “starter microtubules,” the smaller “closed” arrays with specified microtubule number, e.g. in A. pectinata and H. marina, favor a template-driven linkage mechanism. The centroplast is a highly complex microtubule organizing center involved in the control of orientation, number, and diameter of the axonemes. Its shell may serve as a surface upon which the microtubule nucleating sites assemble, but how the precise positioning of these sites occurs is still open to debate. Some of the unsolved problems of microtubule pattern formation may be explained by the “linker nucleation hypothesis” which is an extension of the “gradion hypothesis” by Roth et al. It is shown how both the formation of closed arrays and the balanced lateral growth of open arrays may result from linker-induced microtubule nucleation.     

Quantification Methodology of “Health Human Resources” Related to “Health Technologies” Based on Indicators “RhSan”, “TechSan” and “RhTech”: Application to Senegal

ObjectivesAfter a century of spectacular advances, healthcare systems are facing unprecedented crisis, linked to shortage of health human resources and health technologies. In fact, availability of care depends on both technological and human resources of health. The objective of this study is to develop indicators that can measure qualitatively human resources and technologies of health in healthcare facilities, in order to assess availability of care in sub-Saharan African countries.Materials and MethodsRegarding “health technology” related to “medical devices”, an indicator called “TechSan” for “Technologies de Santé” was previously developed and published (Ndione FB et al. (2019) [6]). To address the deficiencies in usual indicators related to health human resources, a second indicator called “RhSan” for “Ressources humaines de santé” in French is proposed. This indicator assigns a weight to each health worker taking into account his specific “level of medical knowledge” and “experience”. In order to correlate “RhSan” with “TechSan”, a third indicator called “RhTech” is also developed to assess matches between “health technologies” and “health human resources” and establish realistic availability of care. These indicators have the advantage to be consolidated by specialty such as laboratory, imaging, surgery, and “mother and child care”.ResultsThe application of TechSan, RhSan and RhTech to data collected in Senegal in 2016, enabled to assess the distribution of “health technology” and “health human resources” in this country. They also permit the mapping of care availability per specialty in Senegal. The results show a strong oversupply of Dakar in terms of both human resources and technologies of health compared to other Senegalese regions. Oppositely, Sedhiou, Kaffrine, Matam and Kédougou are poorly endowed showing limits of the Senegalese health pyramid system.ConclusionTechSan, RhSan and RhTech can provide reliable decision-making tools in order to elaborate health policies in sub-Saharan African countries on more rigorous basis.     

When the refugee status becomes an economic asset: how Malians in a Burkinabé City negotiate the “refugee” category

ABSTRACT

Since early 2016, part of the Malian urban refugees living in Bobo-Dioulasso, Burkina Faso, have to “capitalize” on their refugee status to make ends meet. By examining when, why, and how the refugee status transmutes into an economic asset, this article shows how the possibilities to negotiate with the refugee category vary significantly within this group of forced migrants. Indeed, categories are not only imposed on people, but are negotiated by the actors themselves in their interactions and within their social and political economies. My article shows how the refugees’ ability or possibility to participate in the co-construction of their category is shaped by both the social and political context in which they are, as well as by wider intersectional and structural dynamics in which their lives are situated, such as socio-economic class, gender and race.     

Use Of Incretin-Based Therapy in Hospitalized Patients with Hyperglycemia

ObjectiveHyperglycemia is common in hospitalized patients with and without prior history of diabetes and is an independent marker of morbidity and mortality in critically and noncritically ill patients. Tight glycemic control using insulin has been shown to reduce cardiac morbidity and mortality in hospitalized patients, but it also results in hypoglycemic episodes, which have been linked to poor outcomes. Thus, alternative treatment options that can normalize blood glucose levels without undue hypoglycemia are being sought. Incretin-based therapies, such as glucagon-like peptide (GLP)-1 receptor agonists (RAs) and dipeptidyl peptidase (DPP)-4 inhibitors, may have this potential.MethodsA PubMed database was searched to find literature describing the use of incretins in hospital settings. Title searches included the terms “diabetes” (care, management, treatment), “hospital,” “inpatient,” “hypoglycemia,” “hyperglycemia,” “glycemic,” “incretin,” “dipeptidyl peptidase-4 inhibitor,” “glucagon-like peptide-1,” and “glucagon-like peptide-1 receptor agonist.”ResultsThe preliminary research experience with native GLP-1 therapy has shown promise, achieving improved glycemic control with a low risk of hypoglycemia, counteracting the hyperglycemic effects of stress hormones, and improving cardiac function in patients with heart failure and acute ischemia. Large, randomized controlled clinical trials are necessary to determine whether these favorable results will extend to the use of GLP-1 RAs and DPP-4 inhibitors.ConclusionsThis review offers hospitalist physicians and healthcare providers involved in inpatient diabetes care a pathophysiologic-based approach for the use of incretin agents in patients with hyperglycemia and diabetes, as well as a summary of benefits and concerns of insulin and incretin-based therapy in the hospital setting. (Endocr Pract. 2014;20:933-944)     

The Moving Image as Incident of Disappearance

The essay probes the context of an aesthetic of disappearance in recent practice in the moving image in the Philippines. This aesthetic is not one of absence but of a marked incidence of loss, in fact, an index of brutal abduction. It focuses on how both the full-length film and the installative video work mediate the idiom of the long take and the documentary respectively, to flesh out the said aesthetic. Furthermore, the latter form references a political situation in which the state is alleged to organize the scheme to dispose of certain bodies. Such disposition of expendable bodies has been called “extrajudicial,” and it is rendered cinematically in Brillante Mendoza’s Kinatay [2009] and Kiri Dalena’s Time and Place of Incidence [2011] as a passage to a murder as well as to an investigation, thus complicating the feelings of abjection and melancholy and the material condition of disappearance.     

Benchmarking environmental performance of electric insulator supply chain in India using life cycle assessment

Purpose

This study aims at finding the environmental impacts generated by an electric disk insulator supply chain, used for the distribution of electricity by an open wire system, through a case study. This study also aims at benchmarking the environmental impacts of an electric insulator manufacturing process by taking ideal condition of zero waste as reference.

Methods

Cradle-to-grave life cycle assessment (LCA) has been carried out by following the guidelines provided in ISO 14040 series standards and using Umberto NXT software. ReCiPe endpoint and ReCiPe midpoint impact assessment methodologies have been used to calculate environmental impacts under various categories. The primary data has been collected from a medium-scale manufacturer of electric disk insulators located at Bikaner in north-west India. The secondary data has been taken from ecoinvent 3.0 database and literature. The environmental impacts using endpoint assessment (ecosystem quality, human health, and resources) and midpoint assessment (climate change, fossil depletion, human toxicity, metal depletion, ozone depletion, terrestrial acidification, and water depletion) categories have been computed. Finally, the results are compared and benchmarked against the ideal zero waste condition using three different production scenarios. The limitation of this study is that the data has been collected only from one manufacturer and its supply chain.

Results and discussion

It has been found that the use of steel, electricity, and fuel; transportation of product; and disposal of water generate high environmental impacts in the supply chain. It has also been found that in the electric disk insulator supply chain, the raw material extraction phase has the highest environmental impacts followed by manufacturing, disposal, transportation, and installation phases. This study has also found that benchmark scenario “B” (zero waste condition) is environmentally more efficient in comparison to scenario “A” (actual recycling condition) and scenario “C” (maximum waste condition).

Conclusions

This study has identified that raw materials, resources, and processes in the supply chain of an electric disk insulator manufacturing unit are responsible for the environmental damage. The various manufacturing processes and installation of the electric disk insulators are similar for all manufacturers except the machinery efficiency and the generated waste. This study provides environmental impacts associated with an electric disk insulator manufacturing process under zero waste or ideal conditions (scenario B). These results are used as a benchmark to compare environmental performance of electric disk insulator supply chain operating under actual conditions.

     

Becoming voluntarily childless: An exploratory study in a Scottish city

Abstract

This paper looks at motives that inform the decision to remain voluntarily childless. It is assumed that voluntary childlessness is not a pathological condition nor is it determined by specific social situations. Situations provide the context within which motives emerge, in the case of voluntary childlessness providing individuals or couples with the opportunity to consider unconventional interpretations of family life that may eventually lead to its rejection. Individuals who become childless prior to finding a “partner” tend to come from families which deviated from the nuclear ideal and to reject parenthood. Those whose decision emerges after a “partnership” has been formed tend to have created alternative life styles and wish to protect the advantages of living without children. It is tentatively concluded that the proportion of couples remaining childless will increase.     

Festuca rohlenae (Poaceae): A neglected taxon of the Montenegro

Abstract

Festuca porcii var. angustifolia is raised to the rank of a species under the new name F. rohlenae. It is an endemic of SE Dinarides in Montenegro, and it is most similar to the Carpathian F. porcii. Both species have the “broad‐leaved syndrome” and exhibit an intermediacy between “fine‐leaved” and “broad‐leaved” fescues. The comparative morpho‐anatomical data and the distribution map as well as basic ecological information of F. rohlenae are herewith presented.     

Shame,reputation and Egypt's lovers: A controversy over the nation's image

This paper addresses aspects of contemporary Egyptian nationalism by focusing on reactions within Egypt to a BBC‐produced documentary dealing with the life of a lower class Cairene woman. In particular, it explores how the notions of honor, shame and reputation are central to the construction and expression of this nationalistic voice, and how the concern over “Egypt's image” involves a contest over who is to represent the nation. This article argues that the contemporary nationalistic voice, championed by the urban middle classes, expresses an ambivalent attitude to both “the West” and “the Egyptian people”, and that it necessarily involves the hiding and undermining of subordinate social groups.     

The Responsible Dog Owner: The Construction of Responsibility

ABSTRACT

Policy and campaigning messages related to dog ownership and welfare center on the concept of responsible ownership. However, the perspectives and experiences of pet owners and how they perceive and perform their responsibilities has not been studied in depth. This qualitative study used conversations about owning and walking dogs in order to elucidate beliefs and views about responsibility in dog ownership. Data comprised 12 in-depth interviews with dog-owning households, 14 short interviews with dog owners while walking their dogs or representing their breed at a dog show, and autoethnography of the first author’s experiences owning and walking dogs. All participants considered themselves responsible dog owners, yet there was great variation in key aspects of their dog-owning behavior. The feelings of responsibility were rooted in the valued unconditional and reciprocal love that owners believed underpinned their human–dog bond. Dogs were described as dependents, similar to, but different from, children. In deciding how to look after their dogs, owners sought to balance their views of dogs as kin, having individual needs to be met, with consideration of the needs of others. Four processes through which issues of irresponsible dog ownership may arise were suggested: owner–dog relationship being too weak or too strong; differences in interpretation of what is best for the dog; difficulties predicting and avoiding situations of conflict; and differences in tolerance of negative impacts of dog ownership. While “responsible dog ownership” has considerable appeal as a concept, how it is perceived and interpreted varies so extensively that simply telling owners that they should “be responsible” is of limited use as a message to promote behavior change. Facilitating “responsible dog ownership” and reducing “irresponsible dog owner” behaviors relies on a detailed understanding of the variables which influence how the dog’s role is constructed within the family and the wider society.     

Moved to Dance: Remix,Rasa, and a New India

This article looks at Bollywood dance to explore the production of the commodified bodies of global consumer culture. It focuses on “embodiment” to examine how dominant sensibilities are altered through changes in dance training and technological innovations. I argue that analyzing the dancing body as a locus of experience and expression shifts the ground from culture as text or discourse (popular in postcolonial, poststructuralist or choreographic analysis) to embodiment of subjectivity. “Remix” is the term that describes both the new training techniques and the aesthetics of Indian dances. Since the older boundaries of high and low, classical and popular are fluid under globalization, “remix” is replacing traditional codes and aesthetic experiences associated with rasa. I draw on my fieldwork among the “background dancers” in Bollywood films to argue that as consumer culture creates the dominant mode of cultural expression in India, the only durable form of dance practice seems to be the practice of consumption.     

The alternative futures of naval force

Abstract

The paper discusses a series of new technologies and new strategic factors entering into naval power and their analytical consequences. The argument is made that (1) traditional ways of identifying “naval power”; no longer have any utility or carry real meaning; (2) current high‐value surface naval forces of declining utility are extremely vulnerable to attack, which will force a radical revaluation in the West of “sea control”; and the costs of such control; and (3) the Soviet Union, by virtue of its geography and its capacity to innovate in “sea denial”; naval force, may be better positioned that the West to take advantage of new antinaval technologies. Western countermeasures may be expensive, involve a radical restructuring of naval force, and mean the acceptance of permanent strategic vulnerability at sea. The “new era”; of naval politics cannot be divorced, analytically and operationally, from emergent space systems and from the strategic nuclear balance.     

Human Perceptions of Coat Color as an Indicator of Domestic Cat Personality

ABSTRACT

Associations between mammalian coat color and behavior have been investigated in a number of species, most notably the study of silver foxes by the Institute of Cytology and Genetics at the Russian Academy of Sciences. However, the few studies conducted regarding a potential relation between coat color and domestic cat personality have shown mixed results, even though many people believe that differently colored cats have distinct personalities. Understanding how humans might perceive personality in relation to coat color may have important ramifications regarding whether cats are relinquished to shelters or adopted from them. In order to assess human perceptions of differently colored cats, we conducted an anonymous, online survey, using a 7-point Likert scale and 10 terms describing personality traits that were chosen based on previous studies of animal personality. This survey examined how people assigned these given terms (active, aloof, bold, calm, friendly, intolerant, shy, stubborn, tolerant, and trainable) to five different colors of cats (orange, tricolored, white, black, and bi-colored). There were significant differences in how participants in this study chose to assign personality terms to differently colored cats. For example, participants (n = 189) were more likely to attribute the trait “friendliness” to orange cats, “intolerance” to tri-colored cats, and “aloofness” to white and tri-colored cats. No significant differences were found for “stubbornness” in any colors of cats. White cats were seen as less bold and active and more shy and calm than other colors of cats. While survey respondents stated that they placed more importance on personality than color when selecting a companion cat, there is some evidence that they believe the two qualities are linked. We anticipate our findings will be relevant to further study in domestic cat personality and to those who work in animal rescue, particularly in how shelters promote differently colored cats and educate potential adopters.