Whiteness and loss in outer East London: tracing the collective memories of diaspora space

Abstract

This paper explores collective memory in Newham, East London. It addresses how remembering East London as the home of whiteness and traditional forms of community entails powerful forms of forgetting. Newham's formation through migration – its ‘great time’ – has ensured that myths of indigeneity and whiteness have never stood still. Through engaging with young people's and youth workers' memory practices, the paper explores how phantasms of whiteness and class loss are traced over, and how this tracing reveals ambivalence and porosity, at the same time as it highlights the continued allure of race. It explores how whiteness and class loss are appropriated across ethnic boundaries and how they are mobilized to produce new forms of racial hierarchy in a ‘super-diverse’ place.     

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport

ABSTRACT

Introduction: Recently, the classification of two ‘novel’ organs, the mesentere and interstitium, was saluted as a scientific breakthrough and disseminated into mainstream media. The novelty of these findings did not pertain to the characterization of some previously unexplored phenomena, rather to the appreciation that well-established tissues may play some hitherto unexplored functions critical to system homeostasis.

Areas covered: Here we provocatively comment on the potential classification of red blood cells – by far the most abundant host cell in the human body (~ 83% of the total cells) – as an organ involved in many functions beyond gas transport. In this perspective article, we describe some of these functions with a special emphasis on the role erythrocytes play with respect to systemic metabolic homeostasis. We thus focus on how these functions modulate the cross talk of red blood cells among each other and with other cell types including immune cells.

Expert commentary: The appreciation of RBCs as an organ impacting systemic metabolic homeostasis and other cell functions while engaging in complex metabolic activity beyond oxygen transport can foster the development of novel therapeutic interventions in pathologic hypoxemia, inflammation, neurodgenerative diseases, aging, and cancer.     

A different contender? Barack Obama,the 2008 presidential campaign and the racial politics of sport

Abstract

This paper explores popular representations of Barack Obama's relationship to sport during the 2008 US presidential campaign. It delineates how white normativity framed the candidate's passion for basketball and his participation in a highly publicized bowling game. We argue that Obama's athletic activities became key vehicles for reading his body and by extension his identity and his politics. The question that could only be asked in a white supremacist context – is Obama too black or not black enough to be President? – mirrored long-standing tensions in America's affective relation to black male athletes. Representations of Obama bowling further illuminate the complicated ways in which whiteness operates. The essay concludes with a brief discussion suggesting the importance of analyses of sport for ethnic and racial studies.     

Transgressing community: the case of Muslims in a twenty-first-century British city

Abstract

This paper draws on ethnographic research carried out in Birmingham, UK – a city significant for its sizeable Muslim population and its iconic role in the history of minority ethnic settlement in Britain – to consider how associations of place and ethnicity work in different ways to inform ideas about ‘Muslim community’ in twenty-first-century Britain. The paper charts happenings around a local event in an area of majority Asian settlement and how representations of the area as a place of Muslim community were used to implicate it in the ‘war on terror’. The paper goes on to show how this sensibility is disrupted by Muslims themselves through alternative engagements with space and ethnicity. The paper argues that these offer a ground for making Muslim community in ways that actively engage with histories and patterns of ethnic settlement in the city rather than being determined by them.     

Regulation of vascular tone by S-nitroso-myoglobin

Abstract

Myoglobin (Mb) is a haem protein present in skeletal, cardiac and smooth muscle where it facilitates the transfer of O₂ from the extracellular matrix to the cell cytosol in a cycle termed 'facilitated O₂-diffusion'. In addition, we showed recently that recombinant human Mb binds endothelium-derived relaxant factor – nitric oxide (?NO) – via formation of both nitrosyl-haem iron and S-nitroso-myoglobin (S-NO-Mb) [Witting PK, Douglas DJ, Mauk AG. Reaction of human myoglobin and nitric oxide. Heme iron or protein sulfhydryl nitrosation dependence on the absence or presence of oxygen. J Biol Chem 2001; 276: 3991–3998]. S-NO-Mb represents a novel form of endothelium-derived relaxant factor (EDRF) that may be important in maintaining optimal ?NO concentrations in the human vasculature. In this study we aim to show that: (i) S-nitrosation of oxygenated ferrous myoglobin (oxyMb) can compete with the rapid oxidation of ?NO by oxyMb; and (ii) S-NO-Mb retains characteristics of physiological EDRF.     

Latino/a professionals as entrepreneurs: how race,class, and gender shape entrepreneurial incorporation

ABSTRACT

This paper examines how race, class, and gender intersect to shape professional Latinos’ entrepreneurial incorporation, as observed by the conditions that prompt professional Latinos to start a business, including access to capital and experiences with discrimination. In-depth interviews with professional Latino business owners in Los Angeles reveal that individual human capital – via resources and wealth accrued through corporate careers – facilitates entrepreneurial activity. Race, ethnicity, and gender, as intersectional social group identities, combine with class to shape variegated impacts on access to capital and business experiences by gender and target market. Ethnicity is a resource for those serving the coethnic community and is more significant in shaping business ownership experiences for men who target a racially/ethnically diverse clientele, whereas gender and race are more salient for women outside the coethnic community. This study contributes to the ethnic enterprise literature by going beyond ethnicity to demonstrate that multiple dimensions of identity shape professional Latino/as’ entrepreneurial incorporation.     

Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data

PurposeTo evaluate patterns of lymph flow from primary lesions in patients with cervical cancer and to determine how useful for radiotherapy planning this information can be.Materials and methodsSPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acquisition started 120–240 min after 4 peritumoral injections of 99mTc-radiocolloids (150–300 MBq in 0.4–1 ml). We determined localization of LN with uptake of radiocolloids, type of lymph flow (mono-, bi-lateral) and lymph flow patterns (supraureteral paracervical, infraureteral paracervical and directly to para-aortic LNs).ResultsSLNs were visualized in 31 of 36 women. Bilateral lymph-flow was detected in 22 (71%), monolateral – in the other 9 (29%) cases. The distribution of SLNs was as follows: external iliac – 64.5%, internal iliac – 54.8%, obturator – 32.2%, common iliac – 35.5% and pre-sacral 3.2%. Para-aortic LNs were visualized in 5 (16.1%) patients. The supraureteral paracervical pattern of lymph flow was identified in 22, infraureteral paracervical – in 4 and their combination – in the other 5 women.ConclusionVisualization of an individual pattern of lymph flow from primary cervical cancer can be considered as a promising tool for optimization of the volume of irradiated regional LNs.     

The Untold Sacrifice: The Monotony and Incompleteness of Self-Sacrifice in Northeast Brazil

There is no such thing as an accidental sacrifice. Sacrifice is always pre-meditated, and if not entirely goal-oriented, at the very least inherently meaningful as a process in itself. This paper is about how we might begin to understand sacrifices that do not conform to these rules. It concerns the question: does sacrifice exist outside of its (often) dramatic, self-conscious elaboration? Within the Brazilian Catholic tradition everyday life – ideally characterised by monotonous, undramatic, acts of self-giving – is ‘true sacrifice’. For ordinary Catholics, the challenge is not how to self-sacrifice, but how to make one's mundane life of self-sacrifice visible whilst keeping one's gift of suffering ‘free’. In this paper I describe, ethnographically, the work entailed as one of ‘revelation’ and use the problems thrown up to reflect upon both the limits and advantages of Western philosophical versus anthropological understandings of Christian sacrificial practices to date.     

Oxygen Adsorption on Zr(0001): An ab Initio Study

Abstract

The main goal of this paper is to study the oxygen adsorption on the Zr(0001) surface using first-principles total-energy calculations based on density-functional theory. We present preliminary results which concern the atomic oxygen adsorption on the Zr(0001) surface. We first report a static study where we calculate the atomic structure and adsorption energy for oxygen occupying various surface and subsurface sites at three different coverages: Θ = 1/4, 1/2, and 1 ML. We find that oxygen atoms are preferentially adsorbed into the octahedral holes between the 2nd and 3rd metallic layers. We secondly perform ab initio molecular dynamics calculations for the Zr(0001) – (3 × 3) – O system to show how the oxygen can penetrate through the surface and how it finally reaches its equilibrium position, trapped between the 1st and 2nd zirconium layers.     

How I learned to love the bomb: excavating pueblo politics,love, and salvaged technologies after conflict

This article analyses the human technology of affect in excavation work in contemporary Spain. While the government continues to avoid addressing crimes committed during the Civil War and the subsequent dictatorship, many Spaniards have taken it upon themselves to address the past. The setting is in Abánades, a right‐wing pueblo destroyed in battle that rebuilt itself through the collecting and selling of battlefield scrap metal. Whereas some archaeologists and heritage managers view the pueblo's obsession with bombs and bullets as strange, I show how the pueblo's deep affection (cariño) for war materials challenges singular narratives of understanding the past. By examining the discovery and care of these materials through sensorial tools – what I call salvage technologies – we can probe the affective mechanics involved in how knowledge of the past is intimately produced and actively challenged in Spain today.     

肠道微生物屏障功能与病原菌毒力作用

人类肠道内存在大量共生菌,其可以抵抗病原菌入侵,对维持人体健康起重要保护作用,被称为肠道微生物屏障。肠道共生菌这种抵抗病原菌入侵保护宿主的作用称为定植抗力。一旦肠道菌群出现紊乱,定植抗力遭到破坏,机体获得感染的机率将明显升高。本综述就共生菌如何限制病原菌生长、抑制病原菌毒力以及反过来病原菌如何躲避竞争、促进菌群紊乱进行了综述。     

Roles of maternal HDL during pregnancy

BackgroundHigh density lipoproteins (HDL) were first linked to cardiovascular disease (CVD) over 30 years ago when an inverse relationship was shown between CVD and HDL-cholesterol levels. It is now apparent that HDL composition and function, not cholesterol levels, are the pertinent measurements describing HDL's role in various disease processes, especially those with subclinical or overt inflammation.Scope of reviewPregnancy is also an inflammatory state. When inflammation becomes excessive during pregnancy, there is an increased risk for adverse outcomes that affect the health of the mother and fetus, including preterm birth and preeclampsia. Though studies on HDL during pregnancy are limited, recent evidence demonstrates that HDL composition and function change during pregnancy and in women with adverse outcomes.General significanceIn this review, we will discuss how HDL may play a role in maintaining a healthy pregnancy and how impairments in function could lead to pregnancies with adverse outcomes.     

National ceremonies: the pursuit of authenticity

Abstract

This article asks what, if any, impact national ceremonies have on the formation of national identities. Why are some ceremonies perceived as national and persistent through time, while others fail to achieve that status? It argues that national ceremonies can only be examined as specific types of situations – performances, rather than rituals – characterized by the relationship between performers and their audiences. Following Jeffery Alexander's cultural pragmatics theory, national ceremonies are seen as successful only when a performance is perceived as authentic. A ceremony's authenticity is, at best, a quality of experience among its audience. Only when the audience is transformed into willing participants through a performance's mise-en-scène can a national ceremony be seen as a ritual-like performance. The paper will conclude that the efficacy of these performances is temporary, and that even when a performance succeeds in creating a community of shared experience, that community dissolves with the end of the performance.     

USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression

BackgroundThe elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination. However, the mechanism of how Cyclin B1 is deubiquitinated and its roles in human glioma remain unclear.MethodsCo-immunoprecipitation and other assays were performed to detect the interacting of Cyclin B1 and USP39. A series of in vitro and in vivo experiments were performed to investigate the effect of USP39 on the tumorigenicity of tumor cells.ResultsUSP39 interacts with Cyclin B1 and stabilizes its expression by deubiquitinating Cyclin B1. Notably, USP39 cleaves the K29-linked polyubiquitin chain on Cyclin B1 at Lys242. Additionally, overexpression of Cyclin B1 rescues the arrested cell cycle at G2/M transition and the suppressed proliferation of glioma cells caused by USP39 knockdown in vitro. Furthermore, USP39 promotes the growth of glioma xenograft in subcutaneous and in situ of nude mice. Finally, in human tumor specimens, the expression levels of USP39 and Cyclin B1 are positively relevant.ConclusionOur data support the evidence that USP39 acts a novel deubiquitinating enzyme of Cyclin B1 and promoted tumor cell proliferation at least in part through Cyclin B1 stabilization, represents a promising therapeutic strategy for tumor patients.     

A small world after all: Globalization and the transformation of childhood in India

This essay investigates the phenomenon of global television in India and how Indian children, particularly those from the upper middle class, are being integrated into a global consumer cuitare. I suggest that in spite of the surface homogeneity of children's culture global capitalism mediates experiences of children differentially depending on class and location. It has led to greater class stratification in children's play and Indian children, unlike their American counterparts, are socialized to be producers rather than consumers.     

Ratatouille: An Animated Account of Cooking,Taste, and Human Evolution

This paper analyzes the immensely popular animated film Ratatouille as a social and cultural document. It begins with a recapitulation of the movie's story line – a saga of an astute, ambitious and talented rat, who becomes transformed into an accomplished haute cuisine chef. The film illustrates recent anthropological writings on the central role of cooking in human evolution. It also shows how varieties of cooking and table manners provide key indications of the civilizing process. Ultimately, Ratatouille explores distinctions and similarities between “man and beast”. It communicates the idea that all living creatures share more in terms of aptitude and feeling than divides them.     

‘They’re my Contacts,not my Friends’: Reconfiguring Affect and Aspirations Through Mobile Communication in Nigeria

ABSTRACT

In Calabar, Nigeria, young women envisage their futures to be full of possibilities. By contrast, their present realities often see them stuck in the house enduring long periods of waiting. Restricted by failing institutions, family and church pressures, and the fear of others’ jealousy, young women find that there is no clear route to realising their aspirations. As they wait alone in the house, they constantly communicate with others on mobile phones and BlackBerries. This paper examines how young women in Calabar use mobile phones as a way of reconceptualising issues of trust, affect and intimacy. It argues that where they employ methods of concealment to chat with others – revealing neither their true identity nor personal details – mobile communication enables distance, becoming an invaluable means for creating new forms of sociality and future opportunities. Illuminating ‘feminine cultures of waiting’, this paper furthers recent analyses of youth, time and productivity.     

The Impact of Guide Dogs on the Identity of People with Visual Impairments

ABSTRACT

This paper explores the effect of peoples' association with guide dogs on how they understand and feel about themselves and how they are regarded by those with whom they interact. The concepts of personal, collective, and social identity are used to situate the discussion. Of central importance is the way working with a guide dog shapes public interaction and how owner' self definitions and social identities are extended by being intimately involved in the owner—dog team.     

Antiviral activity of an aqueous extract derived from Aloe arborescens Mill. against a broad panel of viruses causing infections of the upper respiratory tract

BackgroundA number of antiviral therapies have evolved that may be effectively administered to treat respiratory viral diseases. But these therapies are very often of limited efficacy or have severe side effects. Therefore there is great interest in developing new efficacious and safe antiviral compounds e.g. based on the identification of compounds of herbal origin.HypothesisSince an aqueous extract of Aloe arborescens Mill. shows antiviral activity against viruses causing infections of the upper respiratory tract in vitro we hypothesised that a product containing it such as Biaron C^® could have an antiviral activity too.Study designAntiviral activity of Bioaron C^®, an herbal medicinal product consisting of an aqueous extract of Aloe arborescens Mill., Vitamin C, and Aronia melanocarpa Elliot. succus, added as an excipient, was tested in vitro against a broad panel of viruses involved in upper respiratory tract infections.MethodsThese studies included human adenovirus and several RNA viruses and were performed either with plaque reduction assays or with tests for the detection of a virus-caused cytopathic effect.ResultsOur studies demonstrated an impressive activity of Bioaron C^® against members of the orthomyxoviridae – influenza A and influenza B viruses. Replication of both analysed influenza A virus strains – H1N1 and H3N2 – as well as replication of two analysed influenza B viruses – strains Yamagatal and Beiying – was significantly reduced after addition of Bioaron C^® to the infected cell cultures. In contrast antiviral activity of Bioaron C^® against other RNA viruses showed a heterogeneous pattern. Bioaron C^® inhibited the replication of human rhinovirus and coxsackievirus, both viruses belonging to the family of picornaviridae and both representing non-enveloped RNA viruses. In vitro infections with respiratory syncytial virus and parainfluenza virus, both belonging to the paramyxoviridae, were only poorly blocked by the test substance. No antiviral activity of Bioaron C^® was detected against adenovirus – a non-enveloped DNA virus.ConclusionsThese results represent the first proof of a selective antiviral activity of Bioaron C^® against influenza viruses and create basis for further analyses of type and molecular mechanisms of the antiviral activity of this herbal medicine.     

Notes on theorizing racism and other things

ABSTRACT

In the spirit of ‘furthering debate and reflection’ in this response to Theories of Race and Ethnicity, we consider here the pertinence of the theme of resistance that occupies particular chapters within the collection and that has been central to key works within the wider race critical scholarship. Yet, when the larger field of contemporary race study is considered, we also note that other contiguous concerns – including capitalism, religion, nation, and war – are key factors in thinking through racism. Here, we further elaborate on how future theorizations of race and ethnicity must engage with these domains.