共查询到20条相似文献,搜索用时 15 毫秒
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Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication 总被引:3,自引:0,他引:3
Brès V Kiernan R Emiliani S Benkirane M 《The Journal of biological chemistry》2002,277(25):22215-22221
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R E Kiernan C Vanhulle L Schiltz E Adam H Xiao F Maudoux C Calomme A Burny Y Nakatani K T Jeang M Benkirane C Van Lint 《The EMBO journal》1999,18(21):6106-6118
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Chromatin control of HIV‐1 gene expression 总被引:4,自引:0,他引:4
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Polesskaya A Duquet A Naguibneva I Weise C Vervisch A Bengal E Hucho F Robin P Harel-Bellan A 《The Journal of biological chemistry》2000,275(44):34359-34364
The myogenic protein MyoD requires two nuclear histone acetyltransferases, CREB-binding protein (CBP)/p300 and PCAF, to transactivate muscle promoters. MyoD is acetylated by PCAF in vitro, which seems to increase its affinity for DNA. We here show that MyoD is constitutively acetylated in muscle cells. In vitro, MyoD is acetylated both by CBP/p300 and by PCAF on two lysines located at the boundary of the DNA binding domain. MyoD acetylation by CBP/p300 (as well as by PCAF) increases its activity on a muscle-specific promoter, as assessed by microinjection experiments. MyoD mutants that cannot be acetylated in vitro are not activated in the functional assay. Our results provide direct evidence that MyoD acetylation functionally activates the protein and show that both PCAF and CBP/p300 are candidate enzymes for MyoD acetylation in vivo. 相似文献
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Tat-controlled protein acetylation 总被引:3,自引:0,他引:3
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Wong K Zhang J Awasthi S Sharma A Rogers L Matlock EF Van Lint C Karpova T McNally J Harrod R 《The Journal of biological chemistry》2004,279(53):55667-55674
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Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
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Guidez F Howell L Isalan M Cebrat M Alani RM Ivins S Hormaeche I McConnell MJ Pierce S Cole PA Licht J Zelent A 《Molecular and cellular biology》2005,25(13):5552-5566