Author Keywords: Cold stress; polar regions; human adaptation to cold; vasomotor responses; clothing 相似文献
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Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum
The M37 lipase from Photobacterium lipolyticum shows an extremely low activation energy and strong activity at low temperatures, with optimum activity seen at 298 K and more than 75% of the optimum activity retained down to 278 K. Though the M37 lipase is most closely related to the filamentous fungal lipase, Rhizomucor miehei lipase (RML) at the primary structure level, their activity characteristics are completely different. In an effort to identify structural components of cold adaptation in lipases, we determined the crystal structure of the M37 lipase at 2.2 A resolution and compared it to that of nonadapted RML. Structural analysis revealed that M37 lipase adopted a folding pattern similar to that observed for other lipase structures. However, comparison with RML revealed that the region beneath the lid of the M37 lipase included a significant and unique cavity that would be occupied by a lid helix upon substrate binding. In addition, the oxyanion hole was much wider in M37 lipase than RML. We propose that these distinct structural characteristics of M37 lipase may facilitate the lateral movement of the helical lid and subsequent substrate hydrolysis, which might explain its low activation energy and high activity at low temperatures. 相似文献
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Molecular basis of plant cold acclimation: insights gained from studying the CBF cold response pathway 总被引:5,自引:0,他引:5
Thomashow MF 《Plant physiology》2010,154(2):571-577
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Kevin L Campbell Jay F Storz Anthony V Signore Hideaki Moriyama Kenneth C Catania Alexander P Payson Joseph Bonaventura Jörg Stetefeld Roy E Weber 《BMC evolutionary biology》2010,10(1):214
Background
Elevated blood O2 affinity enhances survival at low O2 pressures, and is perhaps the best known and most broadly accepted evolutionary adjustment of terrestrial vertebrates to environmental hypoxia. This phenotype arises by increasing the intrinsic O2 affinity of the hemoglobin (Hb) molecule, by decreasing the intracellular concentration of allosteric effectors (e.g., 2,3-diphosphoglycerate; DPG), or by suppressing the sensitivity of Hb to these physiological cofactors. 相似文献4.
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G.M. Budd 《Journal of thermal biology》1993,18(5-6):629-631
1. 1. Results from more than half a century of investigation of human adaptation to cold have been so varied that some observers have doubted whether man can adapt to cold at all.
2. 2. This paper considers what challenges to the thermoregulatory system humans experience when living and working in a cold environment (specifically the Antarctic and Subantarctic), what kinds of adaptation have been shown to develop, and what factors might have contributed to the diversity of opinion.
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The structural basis of molecular adaptation 总被引:31,自引:21,他引:10
The study of molecular adaptation has long been fraught with difficulties,
not the least of which is identifying out of hundreds of amino acid
replacements those few directly responsible for major adaptations. Six
studies are used to illustrate how phylogenies, site- directed mutagenesis,
and a knowledge of protein structure combine to provide much deeper
insights into the adaptive process than has hitherto been possible. Ancient
genes can be reconstructed, and the phenotypes can be compared to modern
proteins. Out of hundreds of amino acid replacements accumulated over
billions of years those few responsible for discriminating between
alternative substrates are identified. An amino acid replacement of modest
effect at the molecular level causes a dramatic expansion in an ecological
niche. These and other topics are creating the emerging field of
"paleomolecular biochemistry."
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The host range of retroviruses is rather complex and specific. It is controlled by the products of viral structural genes that interact with the determinants both on the surface and within the cell. The possibility to infect and transform duck embryo fibroblasts is shown for the Prague strain of chicken Rous sarcoma virus (subgroup C), though virus production in these cells is restricted. However, after the 6th passage the "adapted" virus gave the titre practically the same as it was for chicken embryo fibroblasts. Provirus of RSV adapted to the duck embryo fibroblasts and integrated into host DNA was isolated from the library of nucleotide sequences of duck embryo fibroblasts transformed by this virus. The nucleotide sequence of such provirus was determined. The alterations in gp85 coding region of the env gene which proved to be the result of recombination with endogeneous RAV-0 sequences were shown. The formation of viral particles with rather high titre was induced by the proviral transfection on both chicken and duck embryo fibroblasts. The contribution of the revealed alterations in the genome of transformation active virus and possible participation of its td mutant in the adaptation to the new host are discussed. 相似文献
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INGLE DJ 《Federation proceedings》1958,17(4):1064-1065
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M Banet 《Comparative biochemistry and physiology. A, Comparative physiology》1988,89(2):137-140
1. To determine whether long-term cold exposure induces insulative adaptation in the rat, two groups of eight adult animals each were exposed to 4 and 25 degrees C, respectively, for 18 months. 2. At any ambient temperature between -5 and 30 degrees C, the cold adapted animals had a higher rate of oxygen uptake, and higher unfurred skin temperatures than the controls. 3. At ambient temperatures below thermoneutrality, whole body thermal resistance increased continuously in both groups of animals. 4. It is concluded that long-term exposure does not induce insulative adaptation, and that thermal resistance is not maximal at the lower critical temperature. 相似文献
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Local adaptation to cold of Gaspe fishermen 总被引:1,自引:0,他引:1
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K. N. Leibovic 《Biological cybernetics》1971,9(3):96-111
Summary Visual Adaptation poses numerous problems: in some situations bleached pigment and background lights exert equivalent effects on the visual threshold, while in other situations they do not. Adaptation in man spans a range of more that 10 log units, yet receptor polarization—if this be considered as a measure of the response—saturates over 3 or 4 log units in various animals, including primates. To resolve problems such as these, a model is proposed for the responses and interactions of retinal cells, especially receptor, horizontal, and bipolar cells. It is postulated that receptors can give an output either in terms of ionic flux and polarization changes or chemical synaptic activity. These can both contribute to retinal thresholds, which will also depend, however, on the level of bleached pigment in receptors, as well as on processes in the neural network of the retina. The horizontal cells transmit a signal only if the transmission line is opened at each end through synaptic activity. This opening of the line occurs in response to light stimuli, as distinct from those due to bleaching. Bipolar cells integrate the receptor output with the surround inhibition of the horizontal cells. The amacrine cells perform a second difference operation with respect to rates of change. It is argued that the model is consistent with experimental data on cellular and membrane responses in the retina and that various psychophysical data can be explained on this basis. The objective of this paper is to try to understand the responses of an organ in terms of cell responses and interactions. Specifically, the organ here is the eye and the cells are the neurons in the retina. 相似文献
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The molecular genetic basis of plant adaptation 总被引:1,自引:0,他引:1
How natural selection on adaptive traits is filtered to the genetic level remains largely unknown. Theory and quantitative trait locus (QTL) mapping have provided insights into the number and effect of genes underlying adaptations, but these results have been hampered by questions of applicability to real biological systems and poor resolution, respectively. Advances in molecular technologies have expedited the cloning of adaptive genes through both forward and reverse genetic approaches. Forward approaches start with adaptive traits and attempt to characterize their underlying genetic architectures through linkage disequilibrium mapping, QTL mapping, and other methods. Reverse screens search large sequence data sets for genes that possess the signature of selection. Though both approaches have been successful in identifying adaptive genes in plants, very few, if any, of these adaptations' molecular bases have been fully resolved. The continued isolation of plant adaptive genes will lead to a more comprehensive understanding of natural selection's effect on genes and genomes. 相似文献
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